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cognate

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Book Chapter
Series: Chemical Immunology and Allergy
Volume: 88
Published: 11 August 2005
10.1159/000087818
EISBN: 978-3-318-01233-0
... Abstract Antisperm antibodies (ASA) occur in men and in women. In the male they may cause anautoimmune disease, ‘immune infertility’. In order to understand the functional relevance ofASA it is necessary to characterize the cognate antigens of ASA by different methods. In theliterature, several...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 48
Published: 09 March 2017
10.1159/000452906
EISBN: 978-3-318-06014-0
... Abstract Various lines of evidence show that prolactin (PRL) is an immunomodulator in health and disease. Cells of the immune system express PRL receptors and respond to the cognate ligand. Also, PRL itself is produced by several immune cells, indicating that in addition to its classic...
Book Chapter
Series: Current Problems in Dermatology
Volume: 51
Published: 01 September 2016
10.1159/000446788
EISBN: 978-3-318-05905-2
... or MGL_1304 purified from culture of M. globosa or its cognates might be beneficial for patients with intractable CholU due to sweat allergy. Background of Sweat Allergy Atopic dermatitis (AD) is a chronic relapsing eczematous skin disease characterized by pruritus and inflammation, accompanied...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 43
Published: 12 June 2014
10.1159/000360571
EISBN: 978-3-318-02674-0
...-containing low-density lipoproteins resulting in activation of ECs and recruitment of monocytes. Activated ECs secrete ‘chemokines' that interact with cognate chemokine receptors on monocytes and promote directional migration. Recruitment of immune cells establishes a proinflammatory status, further causing...
Book Chapter
Series: Contributions to Nephrology
Volume: 172
Published: 01 September 2011
10.1159/000328697
EISBN: 978-3-8055-9795-1
.... Endothelin (ET)-1 is a potent vasoconstrictor peptide with proinflammatory, mitogenic, and profibrotic effects, and it contributes to both normal renal physiology and pathology. There is robust experimental and clinical evidence for the role of ET-1and its cognate receptors in many progressive renal...
Book Chapter
Series: Monographs in Human Genetics
Volume: 19
Published: 07 March 2011
10.1159/000318837
EISBN: 978-3-8055-9595-7
... and FGFR2cp.P253R. These mutations introduce additional contacts between the mutated FGFR and FGF to increase the affinity of the mutated FGFR for both its cognate FGFs and forFGFs that are outside the normal specificity profile of wild type FGFR. Interestingly, surface plasmon resonance (SPR) data suggest...
Book Chapter
Series: Forum of Nutrition
Volume: 63
Published: 10 December 2009
10.1159/000264402
EISBN: 978-3-8055-9301-4
... to circulating factors that are released during a meal, as well as to adiposity hormones that reflect the availability of stored nutrients. Brainstem neurons themselves express eating modulatory neuropeptides as well as their cognate receptors, raising the possibility that local ligand-receptor interactions...
Book Chapter
Series: Current Directions in Autoimmunity
Volume: 10
Published: 26 May 2008
10.1159/000131456
EISBN: 978-3-8055-8392-3
...; we hypothesize that memory T cells specific for a previouslyencountered virus could cross-react with other antigens, including contact allergens, drugsand other heterologous viruses in the absence of cognate antigen, and cause epidermal damage.This hypothesis provides an explanation for an intimate...
Book Chapter
Series: Current Directions in Autoimmunity
Volume: 8
Published: 28 October 2004
10.1159/000082084
EISBN: 978-3-318-01165-4
... of B cells to become a Bmem or PC occurs largely at the level ofsingle cell fate decisions. Both of these cell populations acquire longevity as a result of antigen-specific, CD40-dependent, cognate interactions with helper T cells within germinal centers(GCs). In addition to these cellular elements...
Book Chapter
Series: Current Directions in Autoimmunity
Volume: 8
Published: 28 October 2004
10.1159/000082105
EISBN: 978-3-318-01165-4
... and non-immune functions. Herein we will discuss the discovery, structure,cognate receptors and functions of these two proteins. ...
Book Chapter
Published: 23 September 1994
10.1159/000424200
EISBN: 978-3-318-04635-9
... for prostaglandin G/H synthase (PGHS) and glyceraldehyde 3-phosphate dehydrogenase. TCDD selectively repressed PGHS gene expression, with maximal inhibition occurring within 60 min. Gel retardation assays demonstrated that dioxin transiently induced binding of the ubiquitous transcription factor NFκB to its cognate...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 90
Published: 13 March 2019
10.1159/000490486
EISBN: 978-3-318-06341-7
... are discovered in marsupials, mapped to bioactive components of milk and their cognate targets in infants, identifying their mechanisms of action and dose dependency. He then revealed a biotechnology pipeline in which these discoveries are rapidly translated into stepwise production systems bringing therapeutic...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 77
Published: 29 April 2016
EISBN: 978-3-318-05651-8
..., Hirose B, Shirasaki H, Izumi T, Takami T, Himi T, Sato N: Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help. Am J Pathol 2011;178:222-232. 9. Kamekura R, Shigehara K, Miyajima S, Jitsukawa S, Kawata K, Yamashita K, Nagaya T...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324588
EISBN: 978-3-8055-9723-4
... IgD and IgM (sIgD+sIgM+) - both co-expressed isotypes exhibiting the same specificity for antigen. Germinal centers (GCs) are hallmarks of secondary follicles generated after stimulation of naïve B cells immediately outside the follicles through cognate help from activated CD4+ T cells [ 3...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 42
Published: 10 April 2014
10.1159/000358322
EISBN: 978-3-318-02639-9
... Hormones The gustatory system is the first biochemical gateway that identifies and controls food intake and thereby helps maintain somatic energy homeostasis. There is increasing evidence that demonstrates the presence of several metabolic hormones and their cognate receptors in subsets of taste cells...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 5
Published: 04 July 2016
EISBN: 978-3-318-05867-3
.... J Exp Med 1997;186:1749-1756. 29. Yoshizaki A, Miyagaki T, DiLillo DJ, Matsushita T, Horikawa M, Kountikov EI, et al: Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature 2012;491:264-268. 30. Maseda D, Candando KM, Smith SH, Kalampokis I...
Book Chapter
Series: Contributions to Nephrology
Volume: 183
Published: 16 May 2014
10.1159/000360121
EISBN: 978-3-318-02651-1
... a cognate sequence of this miRNA is present. As a result, the RISC represses the translation of this mRNA molecule or directly degrades it. Therefore, miRNAs function to inhibit the expression of the target genes that harbor a cognate sequence of the miRNAs. Each miRNA is predicted to target hundreds...
Book Chapter
Series: Endocrine Development
Volume: 23
Published: 26 November 2012
EISBN: 978-3-318-02245-2
... and IGF2 with their cognate receptor. J Mol Biol 2010;400:645-658 24. Pautsch A, Zoephel A, Ahorn H, Spevak W, Hauptmann R, Nar H: Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation. Structure 2001;9:955-965 25. Klammt J, Kiess W...
Book Chapter
Series: ESASO Course Series
Volume: 11
Published: 28 December 2020
EISBN: 978-3-318-06643-2
... ischemia. JAMA Ophthalmol 2013;131:1275–1287. 32. Bonnin S, Krivosic V, Cognat E, Tadyoni R: Visibility of blood flow on optical coherence tomography angiography in a case of branch retinal artery occlusion. J Ophthalmic Vis Res 2018;13:75–77. 33. Dansingani KK, Freund KB: Paracentral acute middle...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 5
Published: 04 July 2016
10.1159/000444976
EISBN: 978-3-318-05867-3
... (mouse: CD1d high CD5 + ) because of its ability to secrete the inhibitory cytokine IL-10. Recent studies have also shown the B10-mediated suppression on autoimmune diseases partially through IL-21-dependent cognate interactions [ 29 , 30 ]. At present, it is difficult to isolate a sufficient number...