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Book Chapter
Series: Translational Research in Biomedicine
Volume: 1
Published: 01 July 2008
10.1159/000141523
EISBN: 978-3-8055-8577-4
... Abstract Chromosomal instability (CIN) is a hallmark of many cancer cells. Several cellular mechanisms have beenproposed to lead to CIN, including abnormal centrosome replication, defects in spindle assembly checkpoint,failed DNA repair and telomere dysfunction. Human T cell leukemia virus 1...
Book Chapter
Series: Genome Dynamics
Volume: 1
Published: 27 March 2006
10.1159/000092506
EISBN: 978-3-318-01290-3
... Abstract Colorectal cancer (CRC) still represents the model of choice to study the mechanismsunderlying tumor initiation and progression. Accordingly, CRC has been central in the analysisof the role played by chromosomal instability (CIN) in tumor initiation and progression.Although loss of APC...
Book Chapter
Series: Contributions to Nephrology
Volume: 174
Published: 15 September 2011
10.1159/000329387
EISBN: 978-3-8055-9811-8
... Abstract In order to prevent a disease, its temporal nature (or at least when it starts) needs to be clearly defined. In acute kidney injury (AKI), this is usually not possible because the current diagnostic criteria are retrospective. Contrast-induced nephropathy (CIN) and cardiac surgery...
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