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chromogranin
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Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 23
Published: 21 December 1994
10.1159/000423495
EISBN: 978-3-318-03646-6
Book Chapter
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
10.1159/000381981
EISBN: 978-3-318-02773-0
..., such as chromogranin A, chromogranin B or pancreatic polypeptide. Chromogranin A is produced by the majority of endocrine tumors, both functioning and nonfunctioning, and is the best available marker for diagnosis, follow-up and treatment monitoring of patients with differentiated neuroendocrine tumors. Examples...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
EISBN: 978-3-318-02773-0
..., Silva MP, Woltering EA, Go VL, Warner R, Caplin M: Biochemical testing for neuroendocrine tumors. Pancreas 2009;38:876-889. 5. Stridsberg M, Öberg K, Li Q, Engström U, Lundqvist G: Measurement of chromogranin A, chromogranin B (secretogranin I), chromogranin C (secretogranin II) and pancreastatin...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
10.1159/000382135
EISBN: 978-3-318-02773-0
.... Immunohistochemical markers can be used to demonstrate neuroendocrine differentiation. Synaptophysin and chromogranin A are, to date, the most reliable and most commonly used for this purpose. Beyond this, other markers can be helpful, for example in the situation of a NET metastasis of unknown primary, where...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 23
Published: 13 March 2009
10.1159/000210050
EISBN: 978-3-8055-9078-5
... behavior. PPTIDs show an intermediate histological grade of malignancy between pineocytomas and pineoblastomas. Immunohistochemically, PPTs are positive for several neuronal markers, including synaptophysin, neurofilaments, class III β-tubulin, and chromogranin A. Photosensory differentiation is associated...
Book Chapter
Series: Frontiers in Diabetes
Volume: 21
Published: 16 February 2012
10.1159/000334493
EISBN: 978-3-8055-9944-3
... (immunohistochemistry for chromogranin A, original magnification x200). Reprinted with permission from Wolters Kluwer/Lippincott Williams and Wilkins [27, p 768]. Fig. 1. K ATP channel hyperinsulinism, diffuse form. a Quantity of endocrine component is not significantly different from pancreas of normoglycemic...
Book Chapter
Series: Monographs in Clinical Cytology
Volume: 22
Published: 21 August 2017
10.1159/000475104
EISBN: 978-3-318-06077-5
... of undifferentiated neuroblastoma, the fibrillary matrix may be missing while large ganglion-like cells are present in more mature tumors. Positive immunostaining for neuron-specific enolase (NSE), chromogranin, and synaptophysin is a common finding, although staining for chromogranin and synaptophysin may...
Book Chapter
Series: Endocrine Development
Volume: 20
Published: 17 December 2010
10.1159/000321211
EISBN: 978-3-8055-9644-2
... cells are regularly found between adrenal medullary cells and vice versa chromaffin cells can be found in all zones of the adrenal cortex ( fig. 1b ) [ 2 ]. a Chromaffin cells are stained red with an antibody to chromogranin A using immunohistochemistry technique. The adjacent...
Book Chapter
Book: Pancreatic Tumors
Series: Monographs in Clinical Cytology
Volume: 26
Published: 05 October 2020
10.1159/000455737
EISBN: 978-3-318-06604-3
... related to the growing mass [ 19 ]. Non-functioning PanNETs secrete a number of substances such as chromogranins, neuron-specific enolase, and pancreatic polypeptide that do not present clinically with a hormonal syndrome. Many non-functioning tumors are detected as incidental findings on radiology...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
10.1159/000382062
EISBN: 978-3-318-02773-0
.... 1 a). Generous tumor sampling is necessary to look for standard histological features of NEN (and immunohistochemistry for chromogranin A, synaptophysin and Ki-67 proliferative marker). Random sampling from the gastric body/fundus mucosa should also be performed to search for associated ECL-like...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
10.1159/000382053
EISBN: 978-3-318-02773-0
... and the site of the primary tumor location. However, all NENs irrespective of their tissue of origin secrete general markers of neuroendocrine differentiation such as chromogranins, neuron-specific enolase, pancreatic polypeptide and alpha subunits that can also facilitate their diagnosis. Serum chromogranin...
Book
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
10.1159/isbn.978-3-318-02773-0
EISBN: 978-3-318-02773-0
Book Chapter
Series: Monographs in Clinical Cytology
Volume: 24
Published: 14 December 2017
10.1159/000479773
EISBN: 978-3-318-06141-3
... or exclude a lobular carcinoma, the neuroendocrine markers chromogranin and synaptophysin, as well as other specific markers used to confirm or exclude the presence of a suspected metastatic neoplasm (e.g., Melan-A and CD45LCA) (Fig. 4 , 5 , 6 ). Fig. 4 E-cadherin immunocytochemistry. E-cadherin...
Book Chapter
Series: Monographs in Clinical Cytology
Volume: 22
Published: 21 August 2017
10.1159/000475108
EISBN: 978-3-318-06077-5
... (previously termed PNET) expresses neuroectodermal markers such as neuron-specific enolase, chromogranin A, and synaptophysin. Histochemistry Cytoplasmic periodic acid-Schiff positivity in classical Ewing sarcoma. Genetics The most common mutation in Ewing sarcoma is the translocation t(11;22...
Book Chapter
Series: Monographs in Clinical Cytology
Volume: 21
Published: 19 October 2011
10.1159/000331039
EISBN: 978-3-8055-9871-2
... shows a cluster of tumor cells with irregular nuclei of varying size and poorly defined scanty cytoplasm (c , May-Grünwald-Giemsa stain). The tumor cells are cytokeratin positive (d ) and chromogranin positive (e ). Three cells are proliferating as detected by Ki-67...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 84
Published: 31 August 2020
10.1159/000457936
EISBN: 978-3-318-06670-8
...-CAM (widespread) with synaptophysin and/or chromogranin (focal/variable) [ 8 ]. SNEC is a true neuroendocrine tumor that should meet all these diagnostic criteria. On the other hand, SNUC usually lacks the evidence of neuroendocrine markers, although SNUC may occasionally demonstrate some focal...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
EISBN: 978-3-318-02773-0
..., Klose KJ, Scherag A, Hahmann M, Müller HH, Barth P: Plasma chromogranin A as marker for survival in patients with metastatic endocrine gastroenteropancreatic tumors. Clin Gastroenterol Hepatol 2008;6:820-827. 18. Papadogias D, Makras P, Kossivakis K, Kontogeorgos G, Piaditis G, Kaltsas G: Carcinoid...
Book Chapter
Book: Pancreatic Tumors
Series: Monographs in Clinical Cytology
Volume: 26
Published: 05 October 2020
10.1159/000455736
EISBN: 978-3-318-06604-3
... for immunostains such as alpha-fetoprotein and hepatocyte antigen just like hepatocellular carcinomas. These tumors stain negative for neuroendocrine markers synaptophysin and chromogranin. Differential Diagnosis Metastatic hepatocellular carcinoma (HCC) is a close differential diagnosis that needs...
Book Chapter
Book: Pancreatic Tumors
Series: Monographs in Clinical Cytology
Volume: 26
Published: 05 October 2020
EISBN: 978-3-318-06604-3
... Sci 2012;57:791–800. 20. Lawrence B, Gustafsson BI, Kidd M, Pavel M, Svejda B, Modlin IM: The clinical relevance of chromogranin A as a biomarker for gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am 2011;40:111–134. 21. Eriksson B, Oberg K, Stridsberg M: Tumor...
Book Chapter
Book: Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA): A Practical Approach
Series: Karger eBooks Non-Series Collection
Published: 22 May 2014
10.1159/000358029
EISBN: 978-3-318-02397-8
... are positive for TTF1 and at least one neuroendocrine marker (e.g. synaptophysin, chromogranin, or CD56), in addition to showing a high proliferation index with Ki67 (fig. 21 ). The differential diagnosis of SCLC in EBUS-TBNA includes benign lymphocytes with artifactual distortion (fig. 22 ), lymphoma (fig...
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