Search Results for channel

... Abstract Aquaporin-5 (AQP5) is a member of the water channel protein family. Although AQP5 has been shown to be present in sweat glands, the presence or absence of regulated intracellular translocation of AQP5 in sweat glands remains to be determined. In this article, recent findings on AQP5...

... Abstract Hydrogen sulfide (H 2 S), a gasotransmitter, is endogenously formed from l-cysteine by certain enzymes including cystathionine-γ-lyase (CSE) in the mammalian body. H 2 S sensitizes Ca v 3.2 T-type calcium channels, leading to excitation of sensory neurons followed by somatic...

... Abstract ATP-sensitive potassium (K ATP ) channels are present in the surface membranes of many organs and cell types. In the pancreatic beta-cell, they play a critical role in coupling glucose metabolism to insulin secretion, and over the last few years, significant advances have been made...

... Abstract The most severe form of congenital hyperinsulinism (HI) is caused by inactivating mutations in the genes encoding the ATP-sensitive potassium (K ATP ) channels. In K ATP HI, loss of functional channels results in inappropriate insulin responses to glucose. Thus, there is a failure...

...' mechanism: (1) a paternally inherited mutation of an ATP-sensitive potassium (K ATP ) channel gene located on the 11p15 chromosome; and (2) in a pancreatic endocrine progenitor, a deletion of the maternally inherited 11p15 chromosomal region, compensated by a paternal uniparental disomy as observed in some...

... Abstract ATP-sensitive potassium (K ATP ) channels regulate the flux of K + ions across the cell membranes and couplecell metabolism to electrical activity. These channels are octameric complexes of 4 pore-forming Kirand 4 regulatory sulphonylurea receptor (SUR) subunits. The K ATP channels...

...,and questions to be addressed. Although fluorescent chloridesensors cannot provide information about single channel electricalproperties, they have been very useful in quantifyingCFTR function in analysis of CFTR mutations, protein-proteininteractions, gene transfer, and high-throughput screening. ...