... Abstract Cell proliferation must be accompanied by increase of cell volume and apoptosis is typicallyparalleled by cell shrinkage. Moreover, profound osmotic cell shrinkage may trigger apoptosis.In isotonic environment cell volume changes require the respective alterations of transportacross...

... Abstract SummaryCultivated human keratinocytes attach to substrate, spread, move, and collide forming multicell clusters in the absence of cell division and collagen synthesis. Tunicamycin profoundly retards the formation of keratinocyte clusters. ...

...Giant Cell Tumor Giant cell tumor (GCT) is a benign but locally aggressive neoplasm comprising approximately 5% of all primary bone tumors. This neoplasm displays a tendency for local recurrences and approximately 2% of GCTs develop pulmonary metastasis, so-called benign metastasizing GCT [ 1...

... Abstract Pancreas and islet transplantation are 2 types of beta-cell replacement therapies for type 1 diabetes mellitus. Since 1966, when pancreas transplantation was first performed, it has evolved to become a highly efficient procedure with high success rates, thanks to advances in surgical...

... Abstract Mesothelial cells are an integral part of the peritoneum and play an important role in maintaining its structure and functions. A number of studies have been performed to evaluate the ability of mesothelial cells to regenerate and transdifferentiate. Mesothelial cells are also involved...

... and vision impairment or blindness. Presently, available treatments can only delay the progress of retinal degeneration, and there are no treatments that can restore permanent vision loss. Research is underway to develop methods of regenerating the impaired retina by delivering photoreceptor precursor cells...

... of many immunoregulatory disorders previously clubbed under the autoimmune umbrella. The severity of presentation and progression, early morbidity and mortality, poor quality of life, and frequent refractoriness to immunosuppressive therapy has prompted studies of stem cell transplantation in many...

... Abstract A reliable method for (repeated) non-invasive quantification of Β-cell mass in vivo in humans will enhance our understanding of the pathophysiology of both type 1 and type 2 diabetes. Individual patients with type 2 diabetes show large differences regarding the relative contribution...

... Abstract Cell migration is typically accomplished by the generation of protrusive mechanicalforces and is achieved by repeated spatially and temporally coordinated cycles includingthe formation of a leading edge, the formation of new and disruption of older adhesions to thesubstratum...