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Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 124
Published: 15 June 2022
10.1159/000517333
EISBN: 978-3-318-06296-0
... Tissue transglutaminase antibodies Enteropathy Malabsorption Malnutrition Gluten-free diet Key Messages Celiac disease (CeD) is a lifelong immune-mediated systemic disorder elicited by gluten and related prolamins from wheat, rye, and barley in genetically susceptible...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 113
Published: 17 April 2015
10.1159/000367874
EISBN: 978-3-318-02691-7
... Celiac disease Gluten-free diet Oats Prevention Gluten-related disorders Key Messages • Celiac disease (CD) is an immune-mediated systemic disorder elicited by gluten and related prolamines in genetically susceptible individuals • CD offers a wide range of clinical...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 108
Published: 12 September 2013
10.1159/000351491
EISBN: 978-3-318-02457-9
... Abstract Celiac disease (CD) is an immune-mediated disease of considerable incidence, which negatively influences the quality of life of affected individuals and their families. The only currently available treatment is a lifelong gluten-free diet. Possible prevention strategies for CD focus...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 68
Published: 06 October 2011
10.1159/000325882
EISBN: 978-3-8055-9746-3
... Abstract Celiac disease is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Gluten is a protein component in wheat and other cereals, including rye and barley that are generally introduced in the infant’s diet at weaning. At present...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 66
Published: 22 July 2010
10.1159/000318949
EISBN: 978-3-8055-9455-4
... Abstract Breast milk is the initial natural food for infants, but already during the second half year complementary feeding is essential. Epidemiological research, first on celiac disease and later on atopic diseases, has driven a paradigm shift with respect to most favorable age to introduce...
Book
Book Cover Image
Series: Fast Facts Collection 2006-2015
Published: 01 August 2009
10.1159/isbn.978-1-905832-67-5
EISBN: 978-1-905832-67-5
Book Chapter
Published: 07 August 2008
10.1159/000155504
EISBN: 978-3-8055-8632-0
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 12
Published: 20 May 2008
10.1159/000128267
EISBN: 978-3-8055-8527-9
... Abstract Ten thousand years ago, celiac disease (CD) appears onthe face of the Earth with the most dramatic change inhuman history: the agricultural revolution that brought toman’s table foods that he had never experienced in hisprevious 2.5 million years. Among them eventually wheatwas...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 12
Published: 20 May 2008
10.1159/000128605
EISBN: 978-3-8055-8527-9
... Abstract In celiac disease a gluten-induced small-bowel mucosallesion develops gradually in genetically susceptible persons.Evidence shows that clinically pertinent celiac disease existsdespite a normal small-bowel villous architecture. The characteristicvillous atrophy with crypt hyperplasia...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 12
Published: 20 May 2008
10.1159/000128609
EISBN: 978-3-8055-8527-9
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 12
Published: 20 May 2008
10.1159/000128610
EISBN: 978-3-8055-8527-9
... Abstract Celiac disease (CD) is one of the commonest lifelong disordersin countries populated by individuals of European origin,affecting approximately 1% of the general population.This is a common disease also in North Africa, the MiddleEast and India. The huge prevalence of CD...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 12
Published: 20 May 2008
10.1159/000128613
EISBN: 978-3-8055-8527-9
... Abstract Celiac disease (CD) is a multifactorial disorder in which thecombination of several genetic factors together with anenvironmental trigger is necessary for development of thedisease. Genetic predisposition to CD is complex andincludes the HLA-DQA1*05/ DQB1*02 and HLA-DQA*0301/DQB*0302...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 12
Published: 20 May 2008
10.1159/000128639
EISBN: 978-3-8055-8527-9
... Abstract Celiac disease has a multifactorial background, but there isno doubt that the genetic component contributes most tothe disease. The incidence within families is ten times theincidence among unrelated individuals. Concordancebetween monozygotic twins is more than 80%, as comparedto...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 12
Published: 20 May 2008
10.1159/000128658
EISBN: 978-3-8055-8527-9
... Abstract Celiac disease (CD) is an inflammatory enteropathy inducedby cereal-derived prolamines (gluten) in genetically predisposedindividuals. Prolamines, due to their high proline content,are incompletely digested by enzymes in the intestinallumen and brush border, resulting in the release...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 12
Published: 20 May 2008
10.1159/000128662
EISBN: 978-3-8055-8527-9
... Abstract Celiac disease (CD) is caused by an inflammatory T-cellresponse to gluten and gluten-like proteins present inwheat and related cereals. Gluten is a heterogeneous mix ofproteins, most of which harbor multiple peptides that, aftermodification by the enzyme tissue transglutaminase...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 12
Published: 20 May 2008
10.1159/000128663
EISBN: 978-3-8055-8527-9
... antigen trafficking both through the transcellularand paracellular pathways. When the finely tuned traffickingof macromolecules is deregulated in genetically susceptibleindividuals, autoimmune disorders can occur. Celiac diseaseis characterized by loss of intestinal barrier functions, and evidenceis now...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 12
Published: 20 May 2008
10.1159/000128665
EISBN: 978-3-8055-8527-9
... Abstract Evidence-based guidelines for the diagnosis and treatmentof celiac disease (CD) have recently been published by theNorth American Society for Pediatric Gastroenterology,Hepatology and Nutrition. These recommend the diagnosisbe confirmed with an intestinal biopsy in all cases...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 12
Published: 20 May 2008
10.1159/000128996
EISBN: 978-3-8055-8527-9
... Abstract Early studies determined that proteolytic gluten peptides,not intact gluten protein, were the toxic constituents ofwheat, rye and barley for celiac sprue patients. However,only recently have studies correlated gluten sequence toobserved toxicity. The discovery of HLA-DQ2...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 12
Published: 20 May 2008
10.1159/000129030
EISBN: 978-3-8055-8527-9
... Abstract Celiac disease is the result of an immune response togluten. Gluten exclusion removes the antigen that stimulatesCD4 T-cell-mediated tissue damage in the gut, butdoes not remove the immune response. In fact, glutenexclusion may heighten the immune response stimulatedby gluten since...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 12
Published: 20 May 2008
10.1159/000129065
EISBN: 978-3-8055-8527-9
... Abstract Approximately 1% of the population is intolerant to theimmunogenic food antigen gluten, which results in thechronic illness celiac disease (CD). In genetically predisposedindividuals, gluten evokes a T-cell response resultingin disease development. The only treatment of CD is agluten...