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Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382089
EISBN: 978-3-318-05497-2
... receptor ligands to cognate death receptors triggers the recruitment of signaling molecules to the intracellular part of activated death receptors in order to form the so-called ‘death-inducing signaling complex'. One of the key components of the death-inducing signaling complex is caspase-8, an initiator...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346524
EISBN: 978-3-318-02348-0
... of subsequent adaptive immune responses. In macrophages and monocytes, IL-1β is produced as a pro-cytokine and undergoes enzymatic cleavage by the cysteine protease caspase 1. Caspase 1 itself is processed into its active form upon activation of a multimeric protein complex known as the inflammasome...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 77
Published: 29 April 2016
10.1159/000441884
EISBN: 978-3-318-05651-8
... Abstract Inflammasomes, large protein complexes typically consisting of a Nod-like receptor (NLR), adapter protein apoptosis-associated speck-like protein containing CARD (ASC) and caspase-1, are postulated to be activated in response to danger signals arising from tumors. Inflammasomes...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 96
Published: 16 March 2012
10.1159/000331889
EISBN: 978-3-8055-9895-8
... to play though. The breakdown of filaggrin, a process mediated among others by caspase 14, leads to liberation of hygroscopic amino acids that act as natural moisturizing factors (NMF) [ 5 ]. Caspase 14, a unique member of the cysteinyl aspartate-specific proteinase family, is expressed primarily...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
EISBN: 978-3-318-05497-2
... PA, Herman JG, Pieters R, Versteeg R: Clustering of hypermethylated genes in neuroblastoma. Genes Chromosomes Cancer 2003;38:226-233. 8. Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm FG, Look AT, Lahti JM, Kidd VJ: Caspase 8 is deleted or silenced preferentially...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346505
EISBN: 978-3-318-02348-0
... ]. The release of active IL-1β/IL-18 from ATMs is dependent on autocatalytic activation of procaspase 1 zymogen into enzymatically active 10- and 20-kDa caspase 1 heterodimers [ 13 , 14 ]. The presence of a large N-terminal protein-protein interaction motif called caspase activation recruitment domain (CARD...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315920
EISBN: 978-3-8055-9485-1
... decreased extrinsic and intrinsic apoptotic signaling determined by decreased caspase activity, Fas expression and Bax/Bcl-2 balance. Conclusion: The protective effects of extracorporeal therapy with PMX-B on the development of acute renal failure result, in part, through its ability to reduce...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522460
EISBN: 978-3-318-07054-5
... that induction of apoptosis activates mitochondrial pro-caspase-3 and its dissociation from HSP60. This chaperon protein may in turn accelerate activation of caspase-3 by cytochrome c , the hallmark event of apoptosis. HSP60 also stimulates macrophages to express interleukin-12 and interleukin-15, or rapidly...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
EISBN: 978-3-318-02348-0
... transduction by reactive oxygen species. J Cell Biol 2011;194:7-15. 9. Mantovani A, Cassatella MA, Costantini C, Jaillon S: Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 2011;11:519-531. 10. Mankan AK, Dau T, Jenne D, Hornung V: The NLRP3/ASC/Caspase-1...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346510
EISBN: 978-3-318-02348-0
... Abstract Inflammasomes are a group of protein complexes built around several proteins including NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of exogenous and endogenous microbial, stress and damage signals by inflammasomes results in direct activation of caspase 1, which...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
EISBN: 978-3-318-02348-0
..., Yazdi AS, Thomas CJ, Masin M, Heinz LX, Guarda G, Quadroni M, Drexler SK, Tschopp J: Inflammasome activators induce interleukin-1alpha secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 2012;36:388-400. 4. Jin T, Perry A, Jiang J, Smith P...
Book Chapter
Series: Frontiers of Oral Biology
Volume: 14
Published: 20 April 2010
10.1159/000313708
EISBN: 978-3-8055-9407-3
... or extrinsic pathway) or inside the cell (the mitochondrial or intrinsic pathway) ( fig. 4 ). Both pathways involve the activation of a family of cysteine proteases known as caspases. The caspase machinery acts as a cascade, beginning with the initiator caspases, such as caspases 8 and 9, which cleave...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 96
Published: 16 March 2012
EISBN: 978-3-8055-9895-8
... function and disease. J Cell Sci 2009;122:1285-1294 5. Denecker G, Ovaere P, Vandenabeele P, Declercq W: Caspase-14 reveals its secrets. J Cell Biol 2008;180:451-458 6. Denecker G, Hoste E, Gilbert B, Hochepied T, Ovaere P, Lippens S, et al: Caspase-14 protects against epidermal UVB photodamage...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346509
EISBN: 978-3-318-02348-0
... to represent the main source for IL-1β in the brain. Increased expression of IL-1β has been detected in microglia cells surrounding Aβ plaques in Alzheimer patients, and in animal models of AD [ 28 , 29 ]. The inflammatory protease caspase 1 is required for the cleavage of pro-IL-1β into the biologically...
Book
Book Cover Image
Series: Current Directions in Autoimmunity
Volume: 9
Published: 19 December 2005
10.1159/isbn.978-3-318-01294-1
EISBN: 978-3-318-01294-1
Book Chapter
Series: Frontiers of Hormone Research
Volume: 38
Published: 07 July 2010
10.1159/000318502
EISBN: 978-3-8055-9445-5
... upon activation are shown. Also shown are the key aspartic (D) amino acids in the two putative consensus caspase-sensitive cleavage domains found within the cytoplasmic tail. Fig. 1. The RET/GFRa system. The tyrosine-kinase receptor RET has an extracellular region with consensus cadherin-type...
Book Chapter
Series: Developments in Ophthalmology
Volume: 58
Published: 24 April 2017
10.1159/000455275
EISBN: 978-3-318-06033-1
... growth factor agents, all act in one way or another through these cellular mechanisms. Novel treatments such as neuroprotective agents like nerve growth factors, somatostatins and antiapoptotic agents like calpain, the glutamate blocker memantine, and different caspase inhibitors may in the future...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
EISBN: 978-3-8055-9485-1
..., Nicholson DW: Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 2006;6:813-822 14. Papathanassoglou ED, Moynihan JA, Ackerman MH: Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? a review...
Book Chapter
Series: Contributions to Nephrology
Volume: 169
Published: 14 January 2011
10.1159/000314578
EISBN: 978-3-8055-9538-4
... epithelial cells and activates the renin-angiotensin system, leading to profound changes of the cells, including neo-expression of a large number of molecules which control cell cycle (e.g. caspases, intrinsic and extrinsic death pathway molecules, inhibitors of cyclin-dependent kinases p27 and p21, reactive...
Book Chapter
Series: Yearbook of Pediatric Endocrinology
Published: 14 September 2011
10.1159/000330595
EISBN: 978-3-8055-9860-6
... forward to similar investigations about females. New mechanisms The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity Stienstra R, Joosten LA, Koenen T, van Tits B, van Diepen JA, van den Berg SA, Rensen PC, Voshol PJ, Fantuzzi G, Hijmans...