... Abstract Cancer therapy-induced bone loss (CTIBL), occurring especially in hormone-treated breast and prostate cancer patients, is a noteworthy long-term consequence of cancer treatments. Because of its negative impact on the quality life of cancer survivors, it deserves much attention. We here...

... Abstract Childhood cancer survivors (CCS) are at increased risk of developing thyroid disorders during follow-up. Radiation therapy to a field that includes the thyroid gland and 131 I-meta-iodobenzylguanidine ( 131 I-MIBG) treatment are the main risk factors for thyroid sequelae, which...

... Abstract Breast cancer is not a single disease. Specific biological processes and distinct genetic pathways are associated with prognosis and sensitivity to chemotherapy and targeted agents in different subtypes of breast cancers. As a consequence, breast cancer can be classified by molecular...

... Abstract Constant development of chemotherapy and more recently the introduction of VEGF- and epidermal growth factor receptor (EGFR)-directed agents have improved significantly the treatment of patients with colorectal cancer. In the adjuvant setting, especially for UICC stage III colon cancer...

... Abstract Human cancers usually evolve through multistep processes. These processes are driven by the accumulation of abundant genetic and epigenetic abnormalities. However, some lung cancers depend on a single activated oncogene by somatic mutation, termed ‘driver oncogenic mutations...

... Abstract In ovarian cancer, the clinical development of anticancer agents targeting DNA repair has been associated with significant results because of the elucidation of the different types of damages and repair systems, including PARP. The discovery of the BRCA mutation and its role in ovarian...

... Abstract In addition to diabetes and cardiovascular diseases, epidemiological evidence demonstrates that people who are obese or overweight are at increased risk of developing cancer – colon, breast (in postmenopausal women), endometrial or kidney cancer being among the most frequent...

... and malignancies arisingin non-FA patients. Another notable exception is the FANCF gene which features prominentlyamong the many genes that are silenced in cancer via promoter CpG islandhypermethylation. However, the map location of FANCF adjacent to the 11p hotspot region ofhypermethylation raises concerns about...