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bcl

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Book Chapter
Series: Current Directions in Autoimmunity
Volume: 9
Published: 19 December 2005
10.1159/000090773
EISBN: 978-3-318-01294-1
... malignancy. In contrast, excessive apoptosis of normally long-livedhemopoietic cells can lead to lymphopenia and immunodeficiency. In mammals, cell deathin response to developmental cues and many cell stress signals is regulated by the opposingfactions of the Bcl-2 family of proteins. In particular, the pro...
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Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382089
EISBN: 978-3-318-05497-2
... membrane permeabilization upon its translocation to mitochondrial membranes. The mitochondrial (intrinsic) pathway of apoptosis can be engaged by a large variety of triggers, including proapoptotic proteins of the Bcl-2 family, DNA-damaging agents, cellular stress signals, irradiation and ions (just...
Book Chapter
Series: Current Directions in Autoimmunity
Volume: 9
Published: 19 December 2005
10.1159/000090774
EISBN: 978-3-318-01294-1
... death offer the most reliable form of tolerance to prevent autoimmunity. Inmany cases, death of autoreactive B cells is regulated by the cell intrinsic, or mitochondrialpathway of cell death. The pro-apoptotic Bcl-2 family proteins, Bak, Bax, and Bim have beenshown to be required for disruption...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
EISBN: 978-3-318-05497-2
... and caspase-dependent cleavage of XIAP, Bcl-xL and RIP. Oncogene 2004;23:5415-5425. 29. Abhari BA, Cristofanon S, Kappler R, von Schweinitz D, Humphreys R, Fulda S: RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex. Oncogene...
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Series: Current Directions in Autoimmunity
Volume: 9
Published: 19 December 2005
10.1159/isbn.978-3-318-01294-1
EISBN: 978-3-318-01294-1
Book Chapter
Series: Frontiers of Hormone Research
Volume: 38
Published: 07 July 2010
10.1159/000318491
EISBN: 978-3-8055-9445-5
... in estrogen-modulated cell renewal in the anterior pituitary gland during the estrous cycle could include an increase in the expression of proapoptotic cytokines as well as the increase in the Bax/Bcl-2 ratio at proestrus, when estrogen levels are highest and a peak of apoptosis, in particular of lactotropes...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315920
EISBN: 978-3-8055-9485-1
... decreased extrinsic and intrinsic apoptotic signaling determined by decreased caspase activity, Fas expression and Bax/Bcl-2 balance. Conclusion: The protective effects of extracorporeal therapy with PMX-B on the development of acute renal failure result, in part, through its ability to reduce...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522460
EISBN: 978-3-318-07054-5
... CREB phosphorylation and Bcl-2 expression in cerebellar neurons [ 69 ]. On the other hand, marked increase in NO produced in brain by organophosphates [ 70 ] or excessive NO induced by endotoxin and various pro-inflammatory cytokines [ 71, 72 ] affects oxidative phosphorylation by inhibiting...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522459
EISBN: 978-3-318-07054-5
... anion protein (VDAC) [ 86 ], opening of the mPTP is reciprocally regulated by various Bcl-2 family proteins. Thus, anti-apoptotic proteins such as Bcl-2 and Bcl-xL work to prevent cytochrome c release by stabilizing the mitochondrial membrane barrier function [ 87 ], and pro-apoptotic proteins...
Book Chapter
Series: Forum of Nutrition
Volume: 61
Published: 27 April 2009
10.1159/000212749
EISBN: 978-3-8055-9098-3
... mechanisms underlying the relationship between cell cycle regulation and apoptosis induced by benzyl ITC (BITC), a major ITC compound isolated from papaya (Carica papaya) fruit. We identified phosphorylated Bcl-2 as a key molecule linking p38 MAPK-dependent cell cycle regulation with the c-Jun N-terminal...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 38
Published: 07 July 2010
EISBN: 978-3-8055-9445-5
... the expression of the Bcl-2 family members in the rat anterior pituitary. Endocrinology 1998;139:2465-2471 3. Nolan LA, Kavanagh E, Lightman SL, Levy A: Anterior pituitary cell proliferation control: basal cell turnover and the effects of adrenalectomy and dexamethasone treatment. J Neuroendocrinol 1998;10...
Book Chapter
Published: 23 September 1994
10.1159/000424198
EISBN: 978-3-318-04635-9
... affected by the bcl-2 proto-oncogene. TCDD mediates atrophy induction through its specific receptor (the AhR) and not through effects on the estrogen receptor. Both TCDD and estradiol induce extrathymic T-cell differentiation in the liver. These extrathymic T-cell populations include cells expressing...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 5
Published: 22 December 2014
10.1159/000366568
EISBN: 978-3-318-02732-7
... [ 29 ]. To determine whether p53 or Bcl-2 modulation affects human HSC self-renewal, Dr. Milyavsky and colleagues used NOD/SCID repopulation assay: human HSCs were transduced with control, Bcl-2 or dominant-negative p53KD-expressing lentiviruses, then exposed to gamma IR, followed...
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Series: Frontiers of Neurology and Neuroscience
Volume: 16
Published: 10 December 1997
10.1159/isbn.978-3-318-00255-3
EISBN: 978-3-318-00255-3
Book Chapter
Series: Contributions to Nephrology
Volume: 183
Published: 16 May 2014
10.1159/000360504
EISBN: 978-3-318-02651-1
... inhibitors is decreased, resulting in unopposed cyclin and Cdk activity. The podocytes proliferate ( c , d ). Neurons and podocytes host the atypical Cdk5 and its activators cyclin I and p35. Activation of Cdk5 after injury leads to increased expression and stabilization of the pro-survival proteins Bcl-2...
Book Chapter
Series: Contributions to Nephrology
Volume: 183
Published: 16 May 2014
EISBN: 978-3-318-02651-1
...:1175-1185. 21. Brinkkoetter PT, et al: Cyclin I activates Cdk5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells. J Clin Invest 2009;119:3089-3101. 22. Taniguchi Y, et al: Both cyclin I and p35 are required for maximal survival benefit of cyclin-dependent kinase-5...
Book Chapter
Series: Biovalley Monographs
Volume: 3
Published: 28 August 2012
10.1159/000339188
EISBN: 978-3-8055-9066-2
... resulted in lack of cell death [ 38 ]. Further along this line, apoptosis was significantly reduced in the intestinal mucosa of Tgf-β2(+/-) and Tgf-β3(+/-) heterozygous mice. This decrease in apoptosis was accompanied by an increase in villus length and regulation of apoptosis-associated proteins Bcl-xL...