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autoreactive

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Book Chapter
Series: Current Directions in Autoimmunity
Volume: 6
Published: 30 September 2002
10.1159/000066858
EISBN: 978-3-318-00873-9
Book Chapter
Book Chapter
Series: Current Directions in Autoimmunity
Volume: 3
Published: 23 November 2000
10.1159/000060516
EISBN: 978-3-318-00618-6
Book Chapter
Book Chapter
Series: Current Directions in Autoimmunity
Volume: 9
Published: 19 December 2005
10.1159/000090774
EISBN: 978-3-318-01294-1
... Abstract To prevent autoimmunity, it is critical that tolerance mechanisms block autoantibodyproduction from self-reactive B cells. B cell tolerance is maintained through mechanismsthat can reversibly or irreversibly silence autoreactive B cells. Of these mechanisms, thosethat lead to B cell...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 43
Published: 04 May 2020
10.1159/000504479
EISBN: 978-3-318-06678-4
... does not change, the quality of the B cell response changes; producing less specific antibodies upon challenge and more autoreactive antibodies. This could be due to changes in selection pressures, as has been demonstrated by repertoire sequencing of different subsets of B cells at different ages...
Book Chapter
Series: Frontiers in Diabetes
Volume: 25
Published: 19 April 2017
10.1159/000454744
EISBN: 978-3-318-06025-6
... to abnormal thymic deletion of autoreactive T-lymphocytes, with impaired immune recognition and tolerance; deletion of genes (i.e., FOWP3) playing a crucial role for the function of natural regulatory T-cells; and upregulation of proinflammatory cytokines. On the other hand, abnormal gametogenesis...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 92
Published: 24 January 2007
10.1159/000099270
EISBN: 978-3-318-01404-4
... Abstract Autoimmune disorders of the ocular surface represent a clinically heterogeneousgroup of conditions where acute and chronic autoreactive mechanisms can cause significantdamage to the eye. When severe and affecting the epithelium and substantia propria ofthe conjunctiva, cicatrization...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 88
Published: 11 August 2005
10.1159/000087816
EISBN: 978-3-318-01233-0
..., inflammation is associated with disruption of testicular function, i.e.spermatogenesis. The pattern of lymphocyte infiltration and concomitant damage of seminiferoustubules supports the concept that activation of autoreactive T cells is involved. ...
Book Chapter
Series: Frontiers in Diabetes
Volume: 25
Published: 19 April 2017
10.1159/000454703
EISBN: 978-3-318-06025-6
... “checkpoints” are present in both T- and B-cell development [ 3 ]. The common essential principle upon which all these mechanisms are based is the correct determination of autoreactive cells and nonautoreactive ones, not only during their development, but also later on in life in the periphery. The first...
Book
Book Cover Image
Series: Current Directions in Autoimmunity
Volume: 4
Published: 15 August 2001
10.1159/isbn.978-3-318-00715-2
EISBN: 978-3-318-00715-2
Book
Book Cover Image
Series: Current Directions in Autoimmunity
Volume: 6
Published: 30 September 2002
10.1159/isbn.978-3-318-00873-9
EISBN: 978-3-318-00873-9
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 64
Published: 25 August 2009
10.1159/000235785
EISBN: 978-3-8055-9168-3
... destruction and disease. Tolerance to autoantigens is achieved by combining elimination of potentially autoreactive T cells during their differentiation in the thymus (central tolerance) and potent peripheral regulatory mechanisms (peripheral tolerance) which downmodulate activation or eliminate autoreactive...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 34
Published: 09 July 2015
EISBN: 978-3-318-05474-3
.... Page DM: Cutting edge: thymic selection and autoreactivity are regulated by multiple coreceptors involved in T cell activation. J Immunol 1999;163:3577-3581. 16. Jondal M, Okret S, McConkey D: Killing of immature CD4+ CD8+ thymocytes in vivo by anti-CD3 or 5′-(N-ethyl)-carboxamide adenosine...
Book Chapter
Series: Endocrine Development
Volume: 26
Published: 15 September 2014
10.1159/000363161
EISBN: 978-3-318-02721-1
... they undergo a process of selection and finally exit as CD4+ or CD8+ T cells depleted of high-affinity binding sites of self-peptides [ 10 ]. Central tolerance is accomplished by negative selection of autoreactive T cells in the thymic medulla. These self-reactive T cells emerge during the random recombination...
Book
Book Cover Image
Series: Current Directions in Autoimmunity
Volume: 9
Published: 19 December 2005
10.1159/isbn.978-3-318-01294-1
EISBN: 978-3-318-01294-1
Book Chapter
Series: Contributions to Nephrology
Volume: 195
Published: 22 May 2018
10.1159/000486930
EISBN: 978-3-318-06350-9
... cytotoxicity, and stimulation of the apoptotic pathway. Complement-dependent cytotoxicity is most likely the dominant mechanism in vivo. Rituximab improved abnormalities in B-cell homeostasis, with a decreased proportion of autoreactive memory B cells and reconstitution of the B-cell lineage. Therefore...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 79
Published: 03 August 2016
10.1159/000445129
EISBN: 978-3-318-05854-3
... by inflammation would result in more non-specific activation of a variety of unrelated B-cell clones and could result in autoreactivity. Such an antibody response would suggest a more generalized dysregulation of host mucosal immunity driven by unregulated B-cell activation. Studies regarding antibody specificity...
Book Chapter
Series: Frontiers in Diabetes
Volume: 25
Published: 19 April 2017
EISBN: 978-3-318-06025-6
... protein 3 (FOXP3) mutations lead to increased Th17 cell numbers and regulatory T-cell instability. J Allergy Clin Immunol 2011;128:1376-1379.e1. 16. Kinnunen T, et al: Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells. Blood 2013;121:1595-1603. 17...
Book Chapter
Series: Karger eBooks Non-Series Collection
Published: 21 August 2017
10.1159/000475948
EISBN: 978-3-318-06085-0
...? The involvement of orbital tissues results from a combination of factors, including the presence within the unyielding orbit of: (1) antigenic structures recognized by autoreactive T cells involved in thyroid autoimmune diseases; (2) specific local conditions such as the high level of muscle innervation...