... Abstract ATP-sensitive potassium (K ATP ) channels are present in the surface membranes of many organs and cell types. In the pancreatic beta-cell, they play a critical role in coupling glucose metabolism to insulin secretion, and over the last few years, significant advances have been made...

... Abstract The most severe form of congenital hyperinsulinism (HI) is caused by inactivating mutations in the genes encoding the ATP-sensitive potassium (K ATP ) channels. In K ATP HI, loss of functional channels results in inappropriate insulin responses to glucose. Thus, there is a failure...

... Abstract The beta-cell ATP-sensitive potassium (K ATP ) channel plays a key role in regulating insulin secretion by linking glucose metabolism to cell excitability. The channel is a protein complex composed of four Kir6.2 inwardly rectifying potassium channel subunits and four sulfonylurea...

...' mechanism: (1) a paternally inherited mutation of an ATP-sensitive potassium (K ATP ) channel gene located on the 11p15 chromosome; and (2) in a pancreatic endocrine progenitor, a deletion of the maternally inherited 11p15 chromosomal region, compensated by a paternal uniparental disomy as observed in some...

... Abstract We present an overview of comparative genomics of ATP-dependent DNA packagingsystems of viruses. Several distinct ATPase motors and accessory proteins have been identifiedin DNA-packaging systems of viruses such as terminase-portal systems, the φ29-likepackaging apparatus...