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association

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Book Chapter
Series: Contributions to Nephrology
Volume: 195
Published: 22 May 2018
10.1159/000486934
EISBN: 978-3-318-06350-9
... intake has a beneficial effect on muscle mass has not been demonstrated. In this study, we investigated an association between changes of normalized protein catabolic rate (nPCR), as a proxy for protein intake and percent creatinine generation rate (%CGR), as a proxy for muscle mass in patients receiving...
Book Chapter
Series: Contributions to Nephrology
Volume: 192
Published: 08 February 2018
10.1159/000484276
EISBN: 978-3-318-06251-9
..., was independently associated with increased uric acid (≥7 mg/dL for males, ≥6 mg/dL for females). In longitudinal analysis, uric acid at baseline was an independent factor for a 1-year increase in the UACR. Cox-proportional hazard model analysis with adjustment for possible confounders including age, renal function...
Book Chapter
Series: Frontiers in Diabetes
Volume: 23
Published: 15 September 2014
10.1159/000362463
EISBN: 978-3-318-02700-6
... Abstract Genome-wide association studies (GWAS) provide important insights into type 2 diabetes (T2D) pathogenesis. The common variant GWAS approach enables capture of disease risk-associated sequence variation on a previously unachievable scale, implicating roughly 70 genomic regions in T2D...
Book Chapter
Series: Frontiers in Diabetes
Volume: 23
Published: 15 September 2014
10.1159/000362466
EISBN: 978-3-318-02700-6
... Abstract Genome-wide association studies (GWAS) of patients with type 2 diabetes (T2D) and unaffected controls (case-control studies) have been hugely successful in identifying T2D risk loci. In the first 2 years of GWAS, over 13 loci were found to associate with T2D risk, 4-fold more than...
Book Chapter
Series: Frontiers in Diabetes
Volume: 23
Published: 15 September 2014
10.1159/000362467
EISBN: 978-3-318-02700-6
... Abstract Genome-wide association studies (GWAS) of obesity-related traits are defining the genetic architecture of obesity, revealing genes and mechanisms for disease. GWAS have been performed for several measures of obesity including body mass index (BMI), body fat distribution, and fat mass...
Book Chapter
Series: Frontiers in Diabetes
Volume: 23
Published: 15 September 2014
10.1159/000362473
EISBN: 978-3-318-02700-6
... Abstract More than 80 genetic loci affecting type 2 diabetes (T2D) risk have been published to date. However, the causative variant(s) and biology underlying the associations at the vast majority of these loci remain elusive, in part due to an incomplete understanding of the genes and pathways...
Book Chapter
Series: Contributions to Nephrology
Volume: 181
Published: 13 May 2013
10.1159/000348652
EISBN: 978-3-318-02390-9
..., together with the known familial aggregation of disease, suggests an inherited mechanism. Recently three genome-wide association studies (GWAS) of IgAN have identified seven susceptibility loci, providing initial insight into the genetic architecture of this trait. While genetic studies of complex traits...
Book
Book Cover Image
Published: 14 February 2013
10.1159/isbn.978-3-318-02350-3
EISBN: 978-3-318-02350-3
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 71
Published: 24 January 2013
10.1159/000342541
EISBN: 978-3-318-02270-4
... Abstract Despite the high heritability of human growth traits, until recently little was known about the underlying genes and genetic variants which explain normal variation of growth. In the past few years, genome-wide association studies have successfully identified hundreds of genetic...
Book Chapter
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 101
Published: 03 May 2010
10.1159/000314505
EISBN: 978-3-8055-9428-8
... Towards the end of the 20th century, we were successfully beginning to understand part of the genetic basis of some human diseases. Up to that time, progress had been relatively slow, largely depending upon establishing familial associations, and some-what laboriously measured variations...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 27
Published: 13 November 2009
10.1159/000258388
EISBN: 978-3-8055-9309-0
... Abstract Pancreas divisum (PD) is a relatively common congenital variant that has been associated with recurrent acute pancreatitis, chronic pancreatitis and chronic abdominal pain in a minority of affected patients. Diagnosis of PD can be achieved with magnetic resonance imaging or endoscopic...
Book Chapter
Series: Genome Dynamics
Volume: 6
Published: 27 August 2009
10.1159/000235762
EISBN: 978-3-8055-9193-5
... Abstract Protein-protein interaction (PPI) studies are frequently used as a starting point for the functional annotations of unknown proteins according to the principle of ‘guilty by association’. Moreover, they deliver information for the understanding of specific virulence mechanisms. We...
Book Chapter
Series: Developments in Ophthalmology
Volume: 43
Published: 08 June 2009
10.1159/000223835
EISBN: 978-3-8055-9125-6
... Abstract Background: The European Eye Bank Association (EEBA) is a technical-scientific organization for eye banks. Founded in 1989 with the simple objective of sharing information on eye banking, the Association is today the leading pan-national association in Europe dedicated...
Book Chapter
Series: Developments in Ophthalmology
Volume: 43
Published: 08 June 2009
10.1159/000223847
EISBN: 978-3-8055-9125-6
... Abstract Tissue banking is a specific field of medical practice. The European Association of Tissue Banks (EATB) is a scientific nonprofit organization that coordinates and supports aspects of tissue banking within Europe. The evolvement, structure and principal fields of interest...
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Book Chapter
Series: Current Directions in Autoimmunity
Volume: 3
Published: 23 November 2000
10.1159/000060512
EISBN: 978-3-318-00618-6
Book Chapter