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antigen

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Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324590
EISBN: 978-3-8055-9723-4
... Abstract The upper respiratory tract including the nasal cavity, which is the first site of invading antigen exposure, plays a crucial role in host defense via the mucosal immune response. The epithelium of nasal mucosa forms a continuous barrier against a wide variety of exogenous antigens...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324775
EISBN: 978-3-8055-9723-4
... cancer and colon cancer [ 3 ]. However, the desirable administration route of the tumor antigen pulsed DCs to induce effective antitumor response were still unknown. Most head and neck cancer arise from upper respiratory or digestive mucosa and the neck lymph nodes are well known as the draining regional...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/000320816
EISBN: 978-3-8055-9567-4
...The target The homing of leukocytes to sites of infection or tissue damage is key to the development of a normal immune response. The process involves a well-orchestrated series of events typically involving cytokines, chemokines and cell adhesion molecules. VLA-4 (very late activation antigen...
Book Chapter
Book Chapter
Series: Contributions to Nephrology
Volume: 162
Published: 28 October 2008
10.1159/000170812
EISBN: 978-3-8055-8959-8
... Abstract Several protocols have been developed to effectively overcome the blood group barrier in renal transplantation. In the evolution of these protocols, one of the latest steps was the combination of anti-CD20 treatment with antigen-specific immunoadsorptions. Over the last years we have...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000155088
EISBN: 978-3-8055-8629-0
... drives the investigation of antigen-based tolerance in rodent models and in patients. The identification of the key role T-regulatory cells (Tregs) play in avoidance of immunopathology focused on either self or environmental antigens has led to a need to determine whether established and novel tolerance...
Book Chapter
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000154854
EISBN: 978-3-8055-8629-0
... Abstract Among antigen-presenting cells (APCs), dendritic cells as well as monocytes acquire immunostimulatory capacity only after appropriate maturation. Therefore, blockade of the maturation/activation results in a steady state or alternatively activated phenotype, which induces tolerance...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 61
Published: 06 February 2008
10.1159/000113493
EISBN: 978-3-8055-8388-6
... antibody responses mature much earlier, but neonates and infants may require multiple immunizations to achieve or sustain titers comparable to those in older individuals. Neonates can mount effective antigen-specific T cell responses, but CD4 T cell responses are often slower to develop, less readily...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 92
Published: 24 January 2007
10.1159/000099254
EISBN: 978-3-318-01404-4
... Abstract Corneal antigen-presenting cells (APCs) were thought to reside exclusively in the peripheralcornea. However, recent evidence demonstrates that the central cornea is also endowedwith a heterogeneous population of bone marrow-derived cells, including epithelialLangerhans cells (LCs...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 91
Published: 20 January 2006
10.1159/000090278
EISBN: 978-3-318-01266-8
..., in the context of an antigen-presenting cell(APC). The different types of APC and their availability to display particular cytokine productionprofiles, pattern recognition receptors, costimulatory molecules and specific HLAhaplotypes are key determinants for human Th1- and Th2-cell polarization. ...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 89
Published: 11 August 2005
10.1159/000087951
EISBN: 978-3-318-01248-4
... Abstract Maternal tolerance against fetal antigens is still one of the unsolved questions inpregnancy. Focusing on the various subsets of immune cells playing in concert with the humanimmune system, tolerance induction is nowadays often accredited to a specialized group ofimmune cells...
Book Chapter
Book Chapter
Book Chapter
Series: Contributions to Microbiology
Volume: 10
Published: 28 November 2002
10.1159/000068136
EISBN: 978-3-318-00904-0
Book Chapter