Search Results for antigen

... Abstract The upper respiratory tract including the nasal cavity, which is the first site of invading antigen exposure, plays a crucial role in host defense via the mucosal immune response. The epithelium of nasal mucosa forms a continuous barrier against a wide variety of exogenous antigens...

... cancer and colon cancer [ 3 ]. However, the desirable administration route of the tumor antigen pulsed DCs to induce effective antitumor response were still unknown. Most head and neck cancer arise from upper respiratory or digestive mucosa and the neck lymph nodes are well known as the draining regional...

...The target The homing of leukocytes to sites of infection or tissue damage is key to the development of a normal immune response. The process involves a well-orchestrated series of events typically involving cytokines, chemokines and cell adhesion molecules. VLA-4 (very late activation antigen...

... Abstract Several protocols have been developed to effectively overcome the blood group barrier in renal transplantation. In the evolution of these protocols, one of the latest steps was the combination of anti-CD20 treatment with antigen-specific immunoadsorptions. Over the last years we have...

... Abstract Among antigen-presenting cells (APCs), dendritic cells as well as monocytes acquire immunostimulatory capacity only after appropriate maturation. Therefore, blockade of the maturation/activation results in a steady state or alternatively activated phenotype, which induces tolerance...

... drives the investigation of antigen-based tolerance in rodent models and in patients. The identification of the key role T-regulatory cells (Tregs) play in avoidance of immunopathology focused on either self or environmental antigens has led to a need to determine whether established and novel tolerance...

... antibody responses mature much earlier, but neonates and infants may require multiple immunizations to achieve or sustain titers comparable to those in older individuals. Neonates can mount effective antigen-specific T cell responses, but CD4 T cell responses are often slower to develop, less readily...

... Abstract Corneal antigen-presenting cells (APCs) were thought to reside exclusively in the peripheralcornea. However, recent evidence demonstrates that the central cornea is also endowedwith a heterogeneous population of bone marrow-derived cells, including epithelialLangerhans cells (LCs...

..., in the context of an antigen-presenting cell(APC). The different types of APC and their availability to display particular cytokine productionprofiles, pattern recognition receptors, costimulatory molecules and specific HLAhaplotypes are key determinants for human Th1- and Th2-cell polarization. ...

... Abstract Maternal tolerance against fetal antigens is still one of the unsolved questions inpregnancy. Focusing on the various subsets of immune cells playing in concert with the humanimmune system, tolerance induction is nowadays often accredited to a specialized group ofimmune cells...