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antidepressant

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Book Chapter
Series: Advances in Biological Psychiatry
Volume: 29
Published: 23 May 2014
10.1159/000358814
EISBN: 978-3-318-02600-9
... Abstract Depression is a serious common mental disease and complex psychiatric illness often associated with stressful events. Metabonomics, which has been applied in evaluation of mechanisms of depression and therapeutic effects of antidepressants, is a systematic study of the endogenous...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 27
Published: 17 November 2010
10.1159/000319425
EISBN: 978-3-8055-9606-0
... Abstract Major depression is a commonly encountered mental disorder in clinical practice. Although choices of antidepressant drugs appear to be many, all current antidepressant drugs have essentially similar mechanisms of action through the mono aminergic pathways. There remain a significant...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 27
Published: 17 November 2010
10.1159/000319509
EISBN: 978-3-8055-9606-0
... Abstract Current antidepressant treatments have a delayed onset of action and limitations in efficacy, particularly for patients who fail to respond to 2 or more antidepressant trials. Translational neuroscience offers the potential for the development of a new generation of antidepressants...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 27
Published: 17 November 2010
10.1159/000319512
EISBN: 978-3-8055-9606-0
... Abstract Scientific approaches for studying the genetics underlying depression and antidepressant responses using available animal models are reviewed. Numerous examples of genetically defined inbred rodent strains with divergent responses on tests of depressive behavior provide opportunities...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 27
Published: 17 November 2010
10.1159/000319513
EISBN: 978-3-8055-9606-0
... availability of 5-HT is well anchored in the literature, this concept is based mainly on in vitro assays and/or behavioral assays that have little relevance to depression. Our objective herein is to provide a comprehensive overview of the studies that have assessed the effects of antidepressant treatments on 5...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 27
Published: 17 November 2010
10.1159/000319514
EISBN: 978-3-8055-9606-0
... Abstract It is now commonly accepted that neuronal plasticity plays a central role in depression and antidepressant drug action. Accumulating evidence from studies in both humans and animals suggests that depression is associated with alterations in the cellular architecture of specific brain...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 27
Published: 17 November 2010
10.1159/000319515
EISBN: 978-3-8055-9606-0
... hippocampal neurogenesis, has been suggested to be an endpoint of MDD and of antidepressant action. The observation that neurogenesis is increased by antidepressants and that factors involved in the etiology of MDD such as chronic stress can lead to a decrease in neurogenesis and in functional integrity...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 27
Published: 17 November 2010
10.1159/000319517
EISBN: 978-3-8055-9606-0
... Abstract Since the 1950s, clinicians have targeted the same 3 monoamine neurotransmitters to treat depression and have held the antidepressants to the standard of achieving 50% symptom reduction in an average amount of patients on a per study basis. As such, researchers have developed newer...
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Series: International Academy for Biomedical and Drug Research
Volume: 12
Published: 01 April 1997
10.1159/000061360
EISBN: 978-3-318-00227-0
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