Search Results for antibody

... Abstract Treatment of advanced PCLs is limited and rarely reaches complete remission despite aggressive treatment modalities, such as polychemotherapy with various adverse effects. However, several monoclonal antibodies drug agents in patients with advanced primary cutaneous lymphomas...

... Abstract Acute antibody-mediated rejection (AMR) remains an important challenge in the field of kidney transplantation despite the advances in immunosuppressive strategies, and has been recognized as an important cause of allograft dysfunction and graft loss. The treatments of acute AMR...

...), and thyroid-stimulating hormone (TSH). Mutations in PIT-1 cause congenital defects in GH and PRL secretion and severe TSH insufficiency. Anti-PIT-1 antibody syndrome, firstly reported in 2011, is characterized by acquired GH, PRL, and TSH deficiencies without PIT-1 mutation and is associated...

... Abstract The sinonasal mucosa forms a dynamic immune barrier where epithelial cells and the immune system interact with the inhaled environment and nasal microbiome. Recent studies suggest that B-cells, plasma cells and antibody production are highly activated locally within the nasal mucosa...

..., airway smooth muscle accumulation ( 23 ), AHR and mucus hypersecretion ( 24 ). Similar results have been reported using mice deficient in IL-5 ( 25 ) and IL-5Rα ( 26 , 27 ), as well as in mice that have been treated with anti-IL-5 antibodies ( 28 ). In contrast, mice overexpressing IL-5 in lung...

... by intratracheal delivery of IL-13. Blockade of the pathway by a soluble IL-13Rα2 or antibodies against IL-13 results in decreased mucus production, fibrosis and AHR in several murine models ( 12 - 14 ). These findings have been confirmed in a sheep model of asthma and more recently a role for this pathway...

... suppression, via depletion or silencing strategies, will improve on benefits observed with current standard of care in asthma, remains to be seen. Pharmacology MEDI-528 is a fully humanized IgG1/K monoclonal antibody (mAb) derived from a murine anti-human IL-9 mAb. Humanization and affinity maturation...

... Abstract Background/Aims: To summarize current understanding of muscle-specific receptor tyrosine kinase antibody (MuSKAb)-positive and seronegative myasthenia gravis (MG). Methods: We reviewed the current literature on MuSK and seronegative MG, and placed lighter emphasis on seronegative...

... Abstract Numerous retrospective and prospective studies have been conducted to determine the prevalence and significance on long-term graft survival of de novo post-transplant donor-specific antibodies (DSA), directed against both HLA and non-HLA molecules. Moreover, it has been postulated...

... Abstract More than one quarter of renal allograft recipients are susceptible to antibody-mediated rejection (AMR). There are well-established therapies (plasmapheresis, immunoadsorption, intravenous immunoglobulin, rituximab, rATG, splenectomy) to overcome AMR in the short term. However...

... had begunto grow, they were treated either with cisplatin, 5-FU or docetaxel alone or in combinationwith escalating doses of a humanized monoclonal anti-EGFR antibody. ...

... Abstract Systemic lupus erythemaotsus (SLE) is an autoimmune disease involving multiple organsystems and characterized by anti-nuclear antibodies. While T cells and dendritic cells mayplay major roles in SLE, several lines of evidence strongly suggest a central role for B cells.This article...