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Book Chapter
Series: Current Problems in Dermatology
Volume: 53
Published: 13 November 2017
10.1159/000478079
EISBN: 978-3-318-06101-7
... Abstract Treatment of advanced PCLs is limited and rarely reaches complete remission despite aggressive treatment modalities, such as polychemotherapy with various adverse effects. However, several monoclonal antibodies drug agents in patients with advanced primary cutaneous lymphomas...
Book Chapter
Series: Contributions to Nephrology
Volume: 190
Published: 29 May 2017
10.1159/000468962
EISBN: 978-3-318-06061-4
... Abstract Acute antibody-mediated rejection (AMR) remains an important challenge in the field of kidney transplantation despite the advances in immunosuppressive strategies, and has been recognized as an important cause of allograft dysfunction and graft loss. The treatments of acute AMR...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 48
Published: 09 March 2017
10.1159/000452907
EISBN: 978-3-318-06014-0
...), and thyroid-stimulating hormone (TSH). Mutations in PIT-1 cause congenital defects in GH and PRL secretion and severe TSH insufficiency. Anti-PIT-1 antibody syndrome, firstly reported in 2011, is characterized by acquired GH, PRL, and TSH deficiencies without PIT-1 mutation and is associated...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 79
Published: 03 August 2016
10.1159/000445129
EISBN: 978-3-318-05854-3
... Abstract The sinonasal mucosa forms a dynamic immune barrier where epithelial cells and the immune system interact with the inhaled environment and nasal microbiome. Recent studies suggest that B-cells, plasma cells and antibody production are highly activated locally within the nasal mucosa...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/000320807
EISBN: 978-3-8055-9567-4
..., airway smooth muscle accumulation ( 23 ), AHR and mucus hypersecretion ( 24 ). Similar results have been reported using mice deficient in IL-5 ( 25 ) and IL-5Rα ( 26 , 27 ), as well as in mice that have been treated with anti-IL-5 antibodies ( 28 ). In contrast, mice overexpressing IL-5 in lung...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/000320810
EISBN: 978-3-8055-9567-4
... by intratracheal delivery of IL-13. Blockade of the pathway by a soluble IL-13Rα2 or antibodies against IL-13 results in decreased mucus production, fibrosis and AHR in several murine models ( 12 - 14 ). These findings have been confirmed in a sheep model of asthma and more recently a role for this pathway...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/000320812
EISBN: 978-3-8055-9567-4
... suppression, via depletion or silencing strategies, will improve on benefits observed with current standard of care in asthma, remains to be seen. Pharmacology MEDI-528 is a fully humanized IgG1/K monoclonal antibody (mAb) derived from a murine anti-human IL-9 mAb. Humanization and affinity maturation...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 26
Published: 20 April 2009
10.1159/000212372
EISBN: 978-3-8055-9142-3
... Abstract Background/Aims: To summarize current understanding of muscle-specific receptor tyrosine kinase antibody (MuSKAb)-positive and seronegative myasthenia gravis (MG). Methods: We reviewed the current literature on MuSK and seronegative MG, and placed lighter emphasis on seronegative...
Book Chapter
Series: Contributions to Nephrology
Volume: 162
Published: 28 October 2008
10.1159/000170841
EISBN: 978-3-8055-8959-8
... Abstract Numerous retrospective and prospective studies have been conducted to determine the prevalence and significance on long-term graft survival of de novo post-transplant donor-specific antibodies (DSA), directed against both HLA and non-HLA molecules. Moreover, it has been postulated...
Book Chapter
Series: Contributions to Nephrology
Volume: 162
Published: 28 October 2008
10.1159/000170844
EISBN: 978-3-8055-8959-8
... Abstract More than one quarter of renal allograft recipients are susceptible to antibody-mediated rejection (AMR). There are well-established therapies (plasmapheresis, immunoadsorption, intravenous immunoglobulin, rituximab, rATG, splenectomy) to overcome AMR in the short term. However...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 62
Published: 25 November 2004
10.1159/000082475
EISBN: 978-3-318-01119-7
... had begunto grow, they were treated either with cisplatin, 5-FU or docetaxel alone or in combinationwith escalating doses of a humanized monoclonal anti-EGFR antibody. ...
Book Chapter
Series: Current Directions in Autoimmunity
Volume: 8
Published: 28 October 2004
10.1159/000082104
EISBN: 978-3-318-01165-4
... Abstract Systemic lupus erythemaotsus (SLE) is an autoimmune disease involving multiple organsystems and characterized by anti-nuclear antibodies. While T cells and dendritic cells mayplay major roles in SLE, several lines of evidence strongly suggest a central role for B cells.This article...
Book Chapter
Series: Progress in Respiratory Research
Volume: 31
Published: 08 March 2001
10.1159/000062170
EISBN: 978-3-318-00424-3
Book Chapter
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 77
Published: 25 August 2000
10.1159/000058801
EISBN: 978-3-318-00600-1