.... This hypothalamic-pituitary-gonadal (HPG) axis has, therefore, been the target for the development of numerous drugs which regulate it at various points. These include sex steroid agonists and antagonists, inhibitors of sex steroid biosynthesis, and GnRH agonists and antagonists, which have found extensive...

... Abstract The nonvitamin K antagonist oral anticoagulants (NOACs) dabigatran, rivaroxaban, apixaban, and edoxaban are associated with an equal or lower incidence of stroke and systemic embolism and a much lower incidence of intracranial hemorrhage and hemorrhagic stroke than warfarin is, without...

... Abstract Inter-individual differences in responses and remission rates have been observed in patients with inflammatory bowel diseases treated with TNF antagonists. These differences, together with the risk of loss of response in patients initially responding to treatment, have led researchers...

...The target Muscarinic antagonists (also referred to as anticholinergics) are well-established bronchodilators that are prescribed for the management of chronic obstructive pulmonary disease (COPD) ( 1 ). Muscarinic antagonists competitively block the effects of acetylcholine at muscarinic...