... Abstract Acquired idiopathic generalized anhidrosis (AIGA) is a sweating disorder characterized by inadequate sweating in response to heat stimuli such as high temperature, humidity, and physical exercise. Patients exhibit widespread nonsegmental hypohidrosis/anhidrosis without any apparent...

... focal hyperhidrosis that occurs during eating together with reddening of the area in front of the ear following parotid gland surgery or injury. Primary focal hyperhidrosis is particularly common on the palms and soles of the feet, in the axilla, and on the head. Anhidrosis may be either congenital...

..., representative genetic disorders with dyshidrosis, including ectodermal dysplasia (ED), incontinentia pigmenti (IP), Fabry disease, and congenital insensitivity to pain with anhidrosis (CIPA) are discussed. Ectodermal Dysplasia One of the representative diseases is ED, which is a hereditary heterogeneous...

...References References 1. Satoh T, Yokozeki H, Asahina M, Katayama I, Nakazato Y, Watanabe D, et al: Establishment of the Guidelines for the Pathological Analysis and Treatment of Acquired Idiopathic Generalized Anhidrosis. Health, Labour Sciences Research Grant for Research on Measures...

... 2013;40:886-890. 5. Nakazato Y, Tamura N, Ohkuma A, et al: Idiopathic pure sudomotor failure: anhidrosis due to deficits in cholinergic transmission. Neurology 2004;63:1476-1480. 6. Soloman LH, Kener EJ: The ectodermal dysplasia. Arch Dermatol 1980;116:295-299. 7. Weech AA: Hereditary...

... to intradermal injection of their own diluted sweat, representing ‘sweat allergy (hypersensitivity)'. Regarding the direct interaction theory between ACh and mast cells, we found that CholU with anhidrosis and hypohidrosis lacks cholinergic receptor M 3 (CHRM 3 ) expression in eccrine sweat gland epithelial...

... atopic dermatitis: results of the quantitative sudomotor axon reflex test. Br J Dermatol 2002;147:683-688. 18. Maeda A, Yamanouchi H, Lee JB, Katayama I: Oral prednisolone improved acetylcholine-induced sweating in Sjögren's syndrome related anhidrosis. Clin Rheumatol 2000;19:396-397. 19. Higashi...

... associated with acquired generalized hypohidrosis: report of a case and review of the literature. Br J Dermatol 2000;143:1064-1066. 14. Nakazato Y, Tamura N, Ohkuma A, Yoshimaru K, Shimazu K: Idiopathic pure sudomotor failure: anhidrosis due to deficits in cholinergic transmission. Neurology 2004;63:1476...

...: histopathology H&E stain ×40 ( d ) and Dylon stain ×100 ( e ). Among these skin manifestations, we would like to focus on the clinical characteristics of hypohidrosis or anhidrosis and related skin dryness. These skin manifestations might be useful clues for the diagnosis of SS in dermatological...

... of atopic dermatitis complicated by Sjogren's syndrome: link between dry skin and autoimmune anhidrosis. Allergol Int 2011;60:387-391. 10. Katayama I, Bae SJ, Hamasaki Y, Igawa K, Miyazaki Y, Yokozeki H, Nishioka K: Stress response, tachykinin, and cutaneous inflammation. J Investig Dermatol Symp Proc...

... on the muscarinic cholinergic receptor M3 in anhidrotic and hypohidrotic skin. J Invest Dermatol 2010;130:2683-2686. 5. Sawada Y, Nakamura M, Bito T, Sakabe J, Kabashima-Kubo R, Hino R, et al: Decreased expression of acetylcholine esterase in cholinergic urticaria with hypohidrosis or anhidrosis. J Invest...

..., pruritus, and pigmentation of lower leg skin observed in a uremic patient undergoing hemodialysis. Thermoregulatory sweat testing in diabetic subjects involving the measurement of myogram and quantitative sudomotor axon reflexes indicates that anhidrosis areas spread extensively [ 11 ]. Sweat glands...

... state of anxiety in atopic dermatitis. Allergol Int 2012;61:469-473. 9. Kitaba S, Matsui S, Iimuro E, Nishioka M, Kijima A, Umegaki N, Murota H, Katayama I: Four cases of atopic dermatitis complicated by Sjogren's syndrome: link between dry skin and autoimmune anhidrosis. Allergol Int 2011;60:387...

...: Hypohidrosis or anhidrosis attributable to structural changes of the sweat gland. (eds) Sulzberger MB Hermann F: The Clinical Significance of Disturbances in the Delivery of Sweat Springfield, Thomas, 1954; 62-118 27. Rajka G: Sweat secretion. Essential aspects of atopic dermatitis 1989; Springer...

... for the evaluation of sudomotor function with the impression mold technique. Clin Auton Res 2002; 12: 20-23 25. Kennedy WR Sakuta M: Collateral reinnervation of sweat glands. Ann Neurol 1984; 15: 73-78 26. Sulzberger MB Herrmann F: Hypohidrosis or anhidrosis attributable to structural changes...

... various inflammatory cytokines [ 14 , 15 , 16 ], it is likely that leakage of sweat into the dermis could initiate a complex sequence of events that promotes eczematous inflammation. Given the previous finding that the areas of anhidrosis on thermoregulatory sweat testing correspond to their symptomatic...