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anaplastic

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Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382093
EISBN: 978-3-318-05497-2
... Abstract Anaplastic lymphoma kinase (ALK) is a membrane-bound receptor tyrosine kinase that when aberrantly expressed is capable of promoting neuroblastoma pathogenesis, and serves as a bona fide therapeutic target. In this review, we discuss the physiologic role of ALK, the mechanisms...
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Book Chapter
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Book Chapter
Book Chapter
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
EISBN: 978-3-318-05497-2
...References References 1. Mathew P, Morris SW, Kane JR, Shurtleff SA, Pasquini M, Jenkins NA, Gilbert DJ, Copeland NG: Localization of the murine homolog of the anaplastic lymphoma kinase (AlK) gene on mouse chromosome 17. Cytogenet Cell Genet 1995;70:143-144. 2. Chiarle R, Voena C...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 31
Published: 06 February 2018
EISBN: 978-3-318-06059-1
...: Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J Neurosurg 1978;49:333-343. 3. Walker MD, Green SB, Byar DP, Alexander E Jr, Batzdorf U, Brooks WH, Hunt WE, MacCarty CS, Mahaley MS Jr, Mealey J Jr, Owens G, Ransohoff J 2nd, Robertson JT...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 31
Published: 06 February 2018
EISBN: 978-3-318-06059-1
..., Sabel MC, Koeppen S, Ketter R, Meyermann R, Rapp M, Meisner C, Kortmann RD, Pietsch T, Wiestler OD, Ernemann U, Bamberg M, Reifenberger G, von Deimling A, Weller M: NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 31
Published: 06 February 2018
10.1159/000467376
EISBN: 978-3-318-06059-1
.... Traditionally, after maximal surgical resection fractionated radiation therapy was given. However, prospective randomized trials comparing irradiation alone and its combination with chemotherapy demonstrated strong impact of the latter on prolongation of overall survival in 1p/19q co-deleted anaplastic...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 31
Published: 06 February 2018
10.1159/000466922
EISBN: 978-3-318-06059-1
... to be of benefit in clinical trials. Hypofractionated radiation schedules may be applied in elderly patients or those with poor performance status. For anaplastic gliomas, the high-risk region is typically irradiated to a total dose of approximately 60 Gy in 1.8-2 Gy per fraction. For patients with 1p/19q co...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 34
Published: 28 May 2019
10.1159/000493064
EISBN: 978-3-318-06422-3
... Organization grade 3–4 tumors (anaplastic glioma and glioblastoma multiforme; GBM). The management of high-grade glioma (HGG) remains a challenge. During the past decade, modest improvements in survival have been achieved using multimodality options that include surgery when feasible, radiation therapy...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 31
Published: 06 February 2018
10.1159/000467378
EISBN: 978-3-318-06059-1
... of oligodendroglial tumors and predictive marker for response of anaplastic gliomas to PCV chemotherapy, and IDH1 / IDH2 mutations have a strong favorable prognostic value across all glioma histopathological grades. Introduction Up to its 4th edition (2007) the World Health Organization (WHO) classification...
Book
Book Cover Image
Series: Fast Facts Collection 2016
Published: 18 August 2016
10.1159/isbn.978-1-910797-28-0
EISBN: 978-1-910797-28-0
Book Chapter
Series: Monographs in Clinical Cytology
Volume: 22
Published: 21 August 2017
10.1159/000477316
EISBN: 978-3-318-06077-5
... dispersed, slightly atypical, neoplastic plasma cells. MGG and HE stains. d Atypical plasma cells showing a distinctive paranuclear cytoplasmic “Hof.” MGG stain. e Smears of low differentiated (anaplastic) plasmacytoma show highly atypical tumor cells. MGG stain. f Tumor cells are positive for CD138...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 34
Published: 28 May 2019
10.1159/000493065
EISBN: 978-3-318-06422-3
... and found that male gender was significantly associated with worse patient survival. Pathology of Ependymoma Ependymoma corresponds histologically to WHO grade 2, and anaplastic ependymoma corresponds WHO grade 3. Anaplastic ependymomas exhibit high mitotic activity, often accompanied...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 31
Published: 06 February 2018
EISBN: 978-3-318-06059-1
... of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J Neurosurg 1978;49:333-343. 14. Liang BC, Thornton AF Jr, Sandler HM, Greenberg HS: Malignant astrocytomas: focal tumor recurrence after focal external beam radiation therapy. J Neurosurg 1991;75:559-563...
Book Chapter
Series: Monographs in Clinical Cytology
Volume: 23
Published: 05 December 2017
EISBN: 978-3-318-06115-4
... lymphoma associated FGFR1 rearrangement myeloproliferative neoplasm. Diagn Cytopathol 2014;42:45-48. 43. Das P, Iyer VK, Mathur SR, Ray R: Anaplastic large cell lymphoma: a critical evaluation of cytomorphological features in seven cases. Cytopathology 2010;21:251-258. 44. Rekhi B, Sridhar E...
Book
Book Cover Image
Published: 25 April 2019
10.1159/isbn.978-1-912776-31-3
EISBN: 978-1-912776-31-3
Book Chapter
Series: Current Studies in Hematology and Blood Transfusion
Volume: 36
Published: 22 March 1971
10.1159/000391769
EISBN: 978-3-318-03505-6
... large blastoid (anaplastic?) cells with scant cytoplasm and enlarged, pleomorphic nuclei; (2) occasional binucleate or multinucleate cells; (3) many mitoses (many more than found in comparable normal or injured tissue); (4) focal (tumor-like condition) rather than diffuse distribution of blastoid cells...