... Abstract The term anaphylaxis was coined by Charles Richet and Paul Portier when they tried to immunize dogs with actinia extracts, but after a repeated injection of a small amount of the toxin the dog died within 25 min. The new term rapidly spread all over the world. The discovery...

... Abstract Anaphylaxis is the most severe manifestation of a mast cell-dependent reaction. It is a rare disease and most recent data indicates a continuous increase of affected individuals. Limitations regarding the incidence of anaphylaxis are the lack of a unique definition and the fact...

... Abstract Anaphylaxis, occurring during the perioperative period is aclinical syndrome involving multiple organ systems, mostcommonly the skin, the cardiovascular and respiratory systems.The overall incidence is estimated at 1 in 10,000-20,000 anesthetic procedures and 1 in 6,500...

... Abstract Food allergy is a known trigger of anaphylaxis. Although the awareness of food allergies has improved, food-related allergic reactions and anaphylaxis still commonly occur. The recognition of anaphylaxis, its prompt treatment, and patient education are important for the prevention...

... Abstract Anaphylaxis as the maximal variant of an acute systemic hypersensitivity reaction can involve several organ systems, particularly the skin, respiratory tract, gastrointestinal tract and the cardiovascular system. The severity of anaphylactic reaction is variable and can be classified...

... Abstract The application and development of new in vitro techniques aims to enable a diagnosis to be reached while incurring no risk for the patient, a situation which is particularly desirable in the case of severe reactions like anaphylaxis. The in vitro diagnosis of anaphylaxis includes...

... in general. The incidence of anaphylaxis to vital dyes and chlorhexidine increases. Anaphylaxis to intravenous hypnotics, plasma substitutes, aprotinin, protamine and other drugs can occur. Any suspected hypersensitivity reaction during anesthesia must be extensively investigated to confirm the nature...

... Abstract Epinephrine (adrenaline) is universally recommended as the initial drug of choice for the treatment of anaphylaxis. No other medication has similar life-saving pharmacologic effects in multiple organ systems, including prevention and relief of both upper and lower airway obstruction...

... Abstract Anaphylaxis is a term that implies symptoms that are present in many organs, some of which are potentially fatal. The pathogenic process can either be IgE-dependent or non-IgE-dependent; the latter circumstance may be referred to as anaphylactoid. Bradykinin is frequently responsible...

... in the immune system. We have recently demonstrated that basophils and mast cells play distinct roles in systemic anaphylaxis in mice. Basophils are dispensable for IgE-mediated systemic anaphylaxis unlike mast cells. Instead, basophils play the major role in IgG-mediated systemic anaphylaxis. In vivo depletion...

... Abstract Anaphylaxis is the maximal variant of an acute life-threatening immediate-type allergy. Due to its often dramatic onset and clinical course, practical knowledge in the management of these reactions is mandatory both for physicians and patients. It has to be distinguished between acute...

... broke down! Portier and Richet had discovered a completely new and unexpected phenomenon to which they gave the name ‘anaphylaxis'. The experiments leading to the realization of anaphylaxis are described in the historic film ‘Anaphylaxie et Allergie' [see www.karger.com/chial100_movie1] in which...

... Abstract Anaphylaxis is a severe systemic allergic response that is rapid in onset and potentially lethal, and that typically is induced by an otherwise innocuous substance. In IgE-dependent and other examples of anaphylaxis, tissue mast cells and circulating basophilic granulocytes (basophils...

... Abstract Human heart mast cells (HHMC), by elaborating vasoactive mediators, cytokines and chemokines, are the main primary effector cells of anaphylaxis. Mast cells have been identified perivascularly, close to myocytes and in the arterial intima in human heart tissue. Mast cells isolated from...

... Abstract Anaphylaxis and urticaria are the main clinical entities associatedwith betalactam allergy. They usually occur within1 h of drug exposure, although urticaria may occasionallyappear later. The shorter the interval to the reaction, thegreater the possibility of this being IgE mediated...