... Abstract Optical coherence tomography angiography (OCTA) has significantly expanded our knowledge on age-related macular degeneration (AMD) and associated choroidal neovascularization (CNV). The aim of this review is to provide insights into exudative AMD through a recap of OCTA studies...

... Abstract Dry age-related macular degeneration (AMD) is characterized by changes in the outer retina, retinal pigment epithelium (RPE), and choroid. Optical coherence tomography angiography (OCTA) has proven instrumental in analyzing these changes and further understanding the pathogenesis...

... Abstract The discovery of several genetic variants associated with an increased risk for age-related macular degeneration (AMD) has led to a completely new understanding of AMD. In addition to the known modifiable risk factors, genetic risk factors may also help to assess the risk to progress...

... Abstract Age-related macular degeneration (AMD) is a leading cause of vision impairment in elderly people and is becoming a public health problem of great proportions in Western society. AMD is classified in dry AMD (d-AMD) and neovascular AMD depending on the presence of choroidal...

... Abstract Age-related macular degeneration (AMD) is the leading cause of visual impairment in adults over the age of 55 years in industrialized countries. The intermediate stage of AMD is defined by the presence of large drusen and/or AMD pigmentary abnormalities on funduscopic examination...

... Abstract Age-related macular degeneration (AMD) is the most common cause of central vision loss in developed nations and its prevalence has been progressively increasing over the years. Although many factors have been shown to be involved in AMD pathogenesis, it is well established...

... Abstract Epidemiological, histopathological and biochemical evidence indicates that AMD is associated with oxidative damage, lipofuscin accumulation, chronic inflammation, and mutations in the complement system. Molecular targets have been identified that may serve as the basis for developing...

... Abstract Age-related macular degeneration (AMD) is the leading cause of severe vision loss in individuals over the age of 50 years. Choroidal neovascularization (CNV) is the hallmark of ‘wet' or ‘exudative' AMD, and is responsible for approximately 90% of cases of severe vision loss due to AMD...

... Abstract Within the past several decades, a brigade of dedicated researchers from around the world has provided essential insights into the critical niche of immune-mediated inflammation in the pathogenesis of age-related macular degeneration (AMD). Yet, the question has lingered as to whether...

... Abstract Age-related macular degeneration (AMD) is one of the main causes of visual deterioration in the developed nations. AMD comes in many forms but the most devastating form is the exudative (wet) type. Over the years, research into the pathophysiology of AMD has led to the discovery...

... Abstract Optical coherence tomography angiography (OCTA) can be used to visualize alterations in the choriocapillaris of patients with dry age-related macular degeneration (AMD). These changes seem to be present during all stages of the disease. Earlier stages are associated with patchy...

... Abstract We have entered the era of pathway-based therapy for the early and late manifestations of AMD. Each of the treatments mentioned in this chapter acts at a putative step in the pathogenesis of MD. Steps that have been targeted thus far include oxidative damage, lipofuscin accumulation...

... Abstract Suspensions of human embryonic stem cell-derived retinal pigment epithelium (hES-RPE) and human fetal RPE resurface aged and age-related macular degeneration (AMD) Bruch's membrane to a limited degree at day 21 in organ culture. Survival and differentiation of hES-RPE and human fetal...

... Abstract Age-related macular degeneration (AMD) is the most common cause of blindness among people over age 55 years in industrialized countries. Known major risk factors for AMD include: age >55 years, history of smoking, white race, and mutations in various components of the complement...

... Abstract Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in adults aged over 50 years in developed countries. Until recently, argon laser photocoagulation and photo-dynamic therapy (PDT) were the only treatments available for the neovascular form of AMD...

... diseases: The mean CT in wet age-related macular degeneration (AMD) is 171.2 ± 38.5 µm and, similarly, the mean CT in dry AMD is 177.4 ± 49.7 µm. These values are clearly different from the mean CT in vascular polypoidal choroidopathy (438.3 ± 87.8 µm). They are also different from the mean CT values...