... of vascularized composite allotransplantation. Autologous free tissue transfer has changed the face of reconstructive surgery. What was once deemed unsalvageable or nonreconstructable can now be restored to a high level of form and function with a touch of magic. However, and in spite of the refinements...

... Abstract Vascularized composite allotransplantation (VCA) can achieve close to optimal aesthetic restoration of devastating tissue defects not amenable to conventional reconstruction, with improved functional outcomes and avoidance of multiple surgeries or donor site morbidity. During the past...

... Abstract Vascularized composite allotransplantation (VCA) has demonstrated promising results and potential, expanding possibilities for defects not amenable to reconstruction by means of autologous tissue transplantation. Success in VCA relies on multidisciplinary efforts derived from different...

... Abstract Vascularized composite allotransplantation (VCA) poses different challenges to solid organ transplantation because of the immunogenicity difference of different tissues in a single composite allograft, as well as the difficulties in functional assessment of the allograft. The majority...

... detailed in vivo observation into all major domains of vascularized composite allotransplantation research, including rejection and tolerance, structural and functional recoveries, and therapeutic assessments. In the laboratory setting, tissomic studies allow validation of the observed event from...

.... Their characteristics prompted their evaluation as candidate molecular markers and therapeutic agents to monitor or treat patients with vascularized composite allotransplantation (VCA): their specific circulating expression profile that could serve as noninvasive predictive tools or surrogate end points for rejection...

... they can be generated from the patient's own somatic cells through various reprogramming techniques, iPSCs have great potential in disease modeling, drug screening, regenerative medicine, and cell therapy. Vascularized composite allotransplantation (VCA) differs from organ transplantation involving...

... Abstract Vascularized composite allotransplantation (VCA) has emerged as a viable means of restoring forms and functions in patients with significant tissue defects. However, administration of lifelong immunosuppression in VCA is complicated with side effects and reduces immunocompetence...

... Abstract Although vascularized composite allotransplantation (VCA) of the face and extremities has been successfully performed with satisfactory aesthetic and functional outcomes, potentially serious side effects derived from long-term immunosuppression impede broader application of VCA...

...References References 1. Ulusal AE, Ulusal BG, Hung LM, Wei FC: Establishing a composite auricle allotransplantation model in rats: introduction to transplantation of facial subunits. Plast Reconstr Surg 2005;116:811-817. 2. Ulusal AE, Ulusal BG, Hung LM, Wei FC: Heterotopic hindlimb...

... 2002;74:85-90. 5. Schneeberger S, Landin L, Jableki J, et al: Achievements and challenges in composite tissue allotransplantation. Transpl Int 2011;24:760-769. 6. Petruzzo P, Lanzetta M, Dubernard JM, et al: The International Registry on Hand and Composite Tissue Allotransplantation...

...References References 1. Broyles JM, Alrakan M, Ensor CR, Khalifian S, Kotton CN, Avery RK, Brandacher G, Lee WP, Gordon CR: Characterization, prophylaxis, and treatment of infectious complications in craniomaxillofacial and upper extremity allotransplantation: a multicenter perspective...

..., Lefaucheur JP, Ortonne N, Benjoar MD, Lang P, Wolkenstein P: Repair of the lower and middle parts of the face by composite tissue allotransplantation in a patient with massive plexiform neurofibroma: a 1-year follow-up study. Lancet 2008;372:639-645. 3. Pomahac B, Pribaz J, Eriksson E, et al: Three...

... H, Schwibner BH, Som ML: Transplantation of the canine larynx. Ann Surg 1970;172:142–150. 12. Anthony JP, Allen DB, Trabulsy PP, Mahdavian M, Mathes SJ: Canine laryngeal transplantation: preliminary studies and a new heterotopic allotransplantation model. Eur Arch Otorhinolaryngol 1995;252:197...

... allocation, and technical demands of vascularized composite allotransplantation. In this chapter we discuss indications and limitations of toe transfers based on our own experience, as well as provide a rational approach for further advancement of hand transplantation to enhance amputees' quality of life...

... Abstract Vascularized composite allotransplantation (VCA) is the youngest field in organ transplantation. While not necessarily life-saving per se, VCA was introduced with the intention to treat complex and otherwise untreatable tissue injuries and defects of complex body elements...

... 2010;160:315-324. 13. Kuo YR, Chen CC, Goto S, Huang YT, Wang CT, Tsai CC, Chen CL: Immunomodulatory effects of bone marrow-derived mesenchymal stem cells in a swine hemi-facial allotransplantation model. PLoS One 2012;7:e35459. 14. Izadpanah R, Trygg C, Patel B, Kriedt C, Dufour J, Gimble JM...

... Abstract Vascularized composite allotransplantation or reconstructive transplantation is an emerging new era in transplant medicine and has become a viable reconstructive option for patients with large and devastating tissue defects. Advances in microsurgical techniques, transplant immunology...