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Series: Advances in Oto-Rhino-Laryngology
Volume: 79
Published: 03 August 2016
10.1159/000444958
EISBN: 978-3-318-05854-3
... Abstract Allergic fungal rhinosinusitis (AFRS) is the most common form of fungal sinusitis in the United States. Its pathophysiological basis is associated with a predisposed person's type I IgE-mediated allergic response to inhaled mold spores that are ubiquitous in the environment. AFRS...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 77
Published: 29 April 2016
10.1159/000441871
EISBN: 978-3-318-05651-8
... Abstract Cysteinyl leukotrienes (CysLTs) are lipid mediators that have been implicated in the pathogenesis of allergic rhinitis. Pharmacological studies using CysLTs indicate that two classes of receptor exist: CysLT 1 receptor (CysLT 1 R) and CysLT 2 receptor (CysLT 2 R). The CysLT 1 R...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 77
Published: 29 April 2016
10.1159/000441876
EISBN: 978-3-318-05651-8
... Abstract Allergic rhinitis is a chronic inflammatory disease of the upper airways caused by Th2 cell-type cytokines in response to allergen exposure. The inducible costimulator (ICOS), the third member of the CD28/CTLA4 family, plays an important role in immune response. In this study...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 77
Published: 29 April 2016
10.1159/000441878
EISBN: 978-3-318-05651-8
... Abstract Recently, the prevalence of allergic rhinitis has been dramatically increasing worldwide. As conventional therapies for allergic rhinitis, such as antihistamines, leukotriene receptor antagonists, nasal sprays and allergen immunotherapy, have limitations, the development of new drugs...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 85
Published: 25 April 2016
10.1159/000439484
EISBN: 978-3-318-05643-3
... Abstract Food allergy is an important and increasing public health problem worldwide, affecting predominantly infants and young children. There is an urgent need to develop effective treatment strategies to restore oral tolerance in food-allergic individuals. Among diverse research approaches...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 101
Published: 21 May 2015
10.1159/000374080
EISBN: 978-3-318-02341-1
... Abstract There is currently no well-established disease-modifying treatment for food allergy, so management relies upon strict avoidance of food allergen(s), implementation of risk minimisation strategies to avoid inadvertent exposure and allergic reactions, and prompt management of acute...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 100
Published: 27 May 2014
10.1159/000358500
EISBN: 978-3-318-02195-0
... in the 20th century. In the following we want to briefly discuss some of the most important terms used in the description of allergic phenomena in the past. From time to time regional and international organizations have tried to standardize terminology and give clear-cut definitions [ 2 , 3 , 4...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 100
Published: 27 May 2014
10.1159/000358505
EISBN: 978-3-318-02195-0
... Abstract Allergic rhinitis is a very frequent disease with a prevalence of 15-20%. Symptoms are most pronounced in young people while, for some unknown reason, the elderly become clinically hyposensitized. Pollen is the cause of seasonal allergic rhinitis, and house dust mite and animals...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 100
Published: 27 May 2014
10.1159/000358608
EISBN: 978-3-318-02195-0
... Abstract Allergic contact dermatitis is one of the most important dermatologic disorders worldwide - it can cause significant morbidity and decreased quality of life, as well as having major economic implications and loss of vocational productivity. Patch testing is the most important discovery...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 78
Published: 27 January 2014
10.1159/000354954
EISBN: 978-3-318-02531-6
... hydrolyzed casein-based formula may reduce the risk of cow's milk allergy and atopic dermatitis in infants with a family history of atopy. By contrast, asthma and allergic rhinitis at 4-6 years of age are not prevented by this approach. Soy formula and amino acid-based formula have no proven role in allergy...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 77
Published: 30 September 2013
10.1159/000351398
EISBN: 978-3-318-02447-0
... Abstract There has been growing interest in the role of n-3 long-chain polyunsaturated fatty acids (LC-PUFA) in the modulation of the immune response during early childhood and whether this may translate to a reduction in childhood allergic disease. Several randomized controlled trials of n-3...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324631
EISBN: 978-3-8055-9723-4
... Abstract Sublingual immunotherapy has been considered to be a painless and effective therapeutic treatment for allergic rhinitis, and is known as type 1 allergy of the nasal mucosa. So far, its mechanism of action has been elucidated employing peripheral blood serum and lymphocytes...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324632
EISBN: 978-3-8055-9723-4
... inflammation and biological roles of these changes are still unclear. We hypothesized that the extent of sialylation and sulfation of the terminal sugar residues, and mucin gene expression, are different between mucins produced by allergic inflammation and by lipopolysaccharide (LPS) stimulation...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324638
EISBN: 978-3-8055-9723-4
... Abstract Many people all over the world suffer from allergic rhinitis, induced by Th2 responses. CpG DNA, containing a central unmethylated C-G dinucleotide, promotes Th1 responses. Consequently, Th2 responses decrease. Systemic administration of CpG DNA could attenuate allergic rhinitis...
Book Chapter
Series: Developments in Ophthalmology
Volume: 45
Published: 11 May 2010
10.1159/000315022
EISBN: 978-3-8055-9419-6
... ) and birch pollen ( Betula pendula ) on both human tear fluid and conjunctival cell cultures. This study is an approach to seasonal non-allergic conjunctivitis (SNAC) syndrome. Methods: Zymography was carried out in order to investigate the proteolytic activity of the pollen. Thereafter, human tear fluid...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 64
Published: 25 August 2009
10.1159/000235786
EISBN: 978-3-8055-9168-3
... associated with male gender and allergic disorders, such as food allergy, eczema and asthma. The diagnosis relies on demonstration of increased numbers of eosinophils (≥ 15 per high power field) in esophageal biopsies. There is clinical overlap between EE and gastroesophageal reflux disease (GERD). Patients...