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Book Chapter
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382093
EISBN: 978-3-318-05497-2
... Abstract Anaplastic lymphoma kinase (ALK) is a membrane-bound receptor tyrosine kinase that when aberrantly expressed is capable of promoting neuroblastoma pathogenesis, and serves as a bona fide therapeutic target. In this review, we discuss the physiologic role of ALK, the mechanisms...
Book Chapter
Series: Progress in Tumor Research
Volume: 41
Published: 19 February 2014
10.1159/000355902
EISBN: 978-3-318-02542-2
...', for their proliferation and survival. EGFR (epidermal growth factor receptor) mutations and ALK (anaplastic lymphoma kinase) rearrangement are typical examples of such driver oncogenic mutations found in lung adenocarcinomas. EGFR-tyrosine kinase inhibitors (TKIs) or ALK-TKIs significantly improved treatment...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382098
EISBN: 978-3-318-05497-2
... with a debilitating toxicity urgently require novel therapeutic approaches. Genome-wide sequencing studies from primary NB have revealed that related mutations are limited to only a few genes with biological significance like MYCN, PTPN11 and ALK. Recently constitutively activated ALK was identified...
Book Chapter
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
EISBN: 978-3-318-05497-2
...References References 1. Mathew P, Morris SW, Kane JR, Shurtleff SA, Pasquini M, Jenkins NA, Gilbert DJ, Copeland NG: Localization of the murine homolog of the anaplastic lymphoma kinase (AlK) gene on mouse chromosome 17. Cytogenet Cell Genet 1995;70:143-144. 2. Chiarle R, Voena C...
Book Chapter
Series: Monographs in Clinical Cytology
Volume: 25
Published: 11 February 2020
EISBN: 978-3-318-06576-3
... of sarcomas: chromosomal translocations in sarcomas. Arch Pathol Lab Med 2006;130:1199–1207. 3. Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, et al: RET, ROS1 and ALK fusions in lung cancer. Nat Med 2012;18:378–381. 4. Bergethon K, Shaw AT, Ou SH, Katayama R, Lovly CM, McDonald NT, et...
Book Chapter
Series: Monographs in Clinical Cytology
Volume: 25
Published: 11 February 2020
10.1159/000455777
EISBN: 978-3-318-06576-3
..., and immunostaining is displayed in Table 2 . Table 2. Comparison of FISH with IHC and NGS testing Some of the technical difficulties with FISH interpretation occur in cases where signals are difficult to read due to close proximity on the genes of interest or narrow splits (e.g., ALK FISH testing...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382058
EISBN: 978-3-318-05497-2
... to the common MYCN amplification, other rare amplicons have been accurately dissected using these sensitive tools, leading to identification of novel neuroblastoma-related oncogenes such as ALK and LIN28B. A recent wide-scale approach to search for focal gains and losses encompassing genes and miRNAs...
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Book: Cornea
Series: ESASO Course Series
Volume: 6
Published: 11 August 2015
10.1159/000381491
EISBN: 978-3-318-05453-8
... [ 14 ]. Additionally, FSLs have been used to create arcuate incisions to correct high astigmatism in post-keratoplasty corneas [ 15 , 16 ]. FSL systems have been used to create trephinations and dissections both in donor and recipient tissue in PK, anterior lamellar keratoplasty (ALK) and Descemet...
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Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/isbn.978-3-318-05497-2
EISBN: 978-3-318-05497-2
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