... therapies, nonbiological extracorporeal liver support devices are the most widely used, mainly based on detoxification by eliminating accumulated toxins notably by adsorption on specific membranes and/or with plasmapheresis. One of the most recent techniques is the double plasma molecular adsorption system...

... technique. This introductive chapter aims at briefly presenting the phenomenology of the adsorption process, also providing some basic elements related to how to use equilibrium load data to define an adsorption isotherm, which can be used to size a hemoperfusion cartridge. Abstract The removal...

... and the volume of the cartridge vary according to the type of cartridge ranging between 50 Da and 60 kDa. The sorbents, the size of the cartridge, the volume of sorbent, and the pore size (which reaches 60 kDa with the HA330 cartridge) aim to take advantage of the principles of molecular adsorption in a variety...

... plasma from blood and then applying adsorption to plasma or of combining HA with other extracorporeal therapies. Here, we describe a complete appraisal of current available techniques utilizing adsorption. Abstract Sorbents have been utilized in the past for intoxication and poisoning...

... Abstract The mechanism of adsorption is regulated by various factors including the nature of the sorbent and the molecules involved in the adsorption process. The design of a device for adsorption therapies must fulfil specific requirements. The device should allow the use of the minimum amount...

... Abstract In this chapter, anticoagulation treatments for adsorption techniques in continuous renal replacement therapy (CKRT) will be reviewed. Anticoagulation used with adsorption techniques is quite different than anticoagulation in classical CKRT with nonadsorptive therapies. Regional...

... Abstract A strong rationale supports the development of adsorption-based extracorporeal blood purification in conditions such as sepsis, acute kidney disease, uremia, and acute liver failure. The retention of compounds as a consequence of acute or chronic organ dysfunction might have...

... describe targeted patient selection using the endotoxin activity assay and clinical phenotyping followed by adsorption of endotoxin using the PMX-HP for endotoxemic sepsis. Abstract In the fields of sepsis and systemic inflammation, endotoxin might be the most studied molecule since the term...

..., respectively, cannot be removed by classic dialysis; therefore, different extracorporeal techniques have been developed to remove bilirubin from the blood. Plasma adsorption perfusion is an extracorporeal liver support technique in which bilirubin is removed from the plasma through a specific adsorbing...

... of the Hemopurifier in patient treatment. GARNET® The GARNET® (BOA Biomedical, Cambridge, MA) therapeutic filter is another broad-spectrum, pathogen-agnostic, adsorption device that specifically targets and removes pathogens and pathogen fragments. GARNET® utilizes a proprietary bioengineered protein, Fc...

... Abstract Coupled plasma filtration and adsorption (CPFA) is a detoxification system that combines a plasma adsorption circuit and a continuous renal replacement therapy circuit. Its main application is for sepsis and septic shock with or without acute renal failure. Several recent studies have...

... use of extracorporeal blood purification techniques has increased. One of the emergingtreatments in patients with severe sepsis and septic shock is coupled plasma filtration adsorption(CPFA), a novel extracorporeal blood purification therapy aimed at a nonselective reductionof the circulating levels...

... adsorbent recirculating system and the Prometheus systems. Plasmafiltration adsorption dialysis is the latest technology that can combine the best processes ofblood/plasma purification in order to determine a selective and effective purification ofmolecules implicated in liver failure. ...