... Abstract Epinephrine (adrenaline) is universally recommended as the initial drug of choice for the treatment of anaphylaxis. No other medication has similar life-saving pharmacologic effects in multiple organ systems, including prevention and relief of both upper and lower airway obstruction...

... reaction may be treated effectively with an oral anti-histamine. In patients exhibiting the clinical features of anaphylaxis, adrenaline is the only first-line therapy recommended by expert consensus. Adjunctive therapies, including anti-histamines, beta-agonists and glucocorticoids, may be used...

... Abstract The prominence of catecholamines and their congeners in allergic diseases rests chiefly on their use in asthma and acute hypersensitivity reactions, such as anaphylaxis. They act in these indications by activating both α- and β-adrenoceptors. Adrenaline, the prototype, was discovered...

... Abstract In an adult Japanese monkey (Macaca fuscatus), intravenous injections of adrenalin were repeated daily: 0.125 mg/kg for 7 days and 0.375 mg/kg from the 11th day on. In a cynomolgus monkey (Macaca irus), daily injections were carried out with intravenous adrenalin (0.11 mg/kg for 12...

...References References 1. Trendelenburg P: Adrenalin und adrenalinverwandte Substanzen; in Hefter A (ed): Handbuch der experimentellen Pharmakologie. Berlin, Springer, 1924, vol 2, part 2, pp 1130-1293. 2. Blaschko H: Catecholamines 1922-1971; in Blaschko H, Muscholl E (eds...

... Abstract Noradrenaline and adrenaline are the final mediators of sympathoadrenal activity. They exert complex direct and indirect actions on glucose metabolism. Increases in plasma catecholamines - as in patients with pheochromocytoma - as well as in sympathetic activity, causing increased...

... activity was measured during the adrenaline test. The result showed that plasminic activity increased and returned to normal following the bodily response, i.e. the change of pulse rate, blood pressure, pulse wave and urinary catecholamine, to the adrenaline. In the animal experiment, the stimulation...

... the menstruation, the menstruation-like bleeding during pregnancy (M-LB) and the premenstrual tension is related. The adrenalin and the not-adrenalin are one of the factors producing the hemorrhagic phenomena of the endometrium in menstruation. ...

...; bupivacaine which has an even longer duration of action; and prilocaine which has a lower toxicity relative to analgesic potency than comparable drugs.Felypressin, an octapeptide vasoconstrictor used for infiltration at an operation Site, does not cause as much circulatory stimulation as adrenaline...

..., and oral challenges may be needed for diagnostic confirmation. Strict avoidance of these allergens is the current standard of clinical care for allergic patients, and when indicated, an anaphylactic plan with an adrenaline auto-injector is prescribed. There are no published clinical trials evaluating...

... prevalent, severe fruit allergies may be associated with latex (latex-fruit syndrome). Molecular diagnosis is essential in guiding the management and risk assessment of these patients. Current management strategies comprise avoidance and rescue medication, including adrenaline, for severe LTP allergies...

... distinguishes between allergic and non-immune anaphylaxis. Epinephrine (Adrenalin) was soon recognized as treatment of choice of this dramatic condition. Although the term ‘allergy' was coined in 1906 by Clemens von Pirquet [ 1 ], it was the short lecture given by Paul Portier and Charles Richet [ 2...

...-inflammatory cytokines (e.g. interleukin-10, transforminggrowth factor-Β), numerous neuromediators (e.g. adrenalin, acetylcholine), and some otherfactors (e.g. heat shock proteins, ligand of TREM-2, adenosine). These mediators modify theimmune status of circulating leukocytes as illustrated by their decreased...