..., potential side effects and drug interactions have received attention, with recently reported systemic side effects of PPIs found to be related to their potent acid inhibitory effect. Gastric acidity lowered by PPI administration may also be associated with decreased calcium absorption and cause osteoporosis...

... are integrated into the United States Food and Drug Administration’s (FDA) drug development, regulatory review, and approval paradigm, and form the essence of personalized medicine. Factors affecting drug exposure and response, such as patient age, sex, race, and genetic makeup, have gained heightened attention...

... Abstract Human NKT cells are known to have strong antitumor activities and to be activated by specific ligand, α-galactosylceramide (αGelCer). We examined the migration pattern of αGalCer-pulsed DCs and the immune responses after administration by different routes. DCs injected into nasal...

... suggest that ethanol consumption is a positive risk factor for hyperprolactinemia. In animal studies, it was found that chronic ethanol administration not only elevates plasma levels of PRL but also increases proliferation of pituitary lactotropes. Ethanol action on lactotropes involves crosstalk...