... cochlear and support cells must be identified. While virally mediated gene transfer into the inner ear has been accomplished using herpes simplex type I virus, vaccinia virus, retroviruses, adenovirus, and adeno-associated virus (AAV), we will restrict our discussion to AAV and adenoviral vectors. Issues...

... Abstract Therapies for the protection and regeneration of auditory hair cells are of great interest given the significant monetary and lifestyle impact of hearing loss. The past decade has seen tremendous advances in the use of adenoviral vectors to achieve these aims. Preliminary data...

... of an adenoviralvector expressing insulin-like growth factor I corrected their chronic hyperprolactinemia andrestored TIDA neuron numbers. Spontaneous intermediate lobe pituitary tumors in aretinoblastoma (Rb) gene mutant mouse were corrected by injection of an adenoviral vectorexpressing the human Rb cDNA...

..., and adenoviral vectors. Transduction efficiency with cationic liposomes is low and the effect is transient; with adeno-associated and lentiviral vectors, long-term transfection is possible using a small hairpin RNA expression cassette. ...

... induces mesangial cellproliferation in vitro and is overexpressed in mesangioproliferative glomerulonephritis invivo. Hepatic transfection with an adenoviral vector expressing PDGF-D induced prominentmesangioproliferative nephritis in mice, whereas antagonism of PDGF-D in a rat model...

... detection and resection. Sci Trans Med 2011;3:110fs10. 7. Kishimoto H, Zhao M, Hayashi K, Urata Y, Tanaka N, Fujiwara T, Penman S, Hoffman RM: In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation. Proc Natl Acad Sci USA 2009;106:14514-14517. 8...

... and Methods Animals Specific pathogen-free male BALB/c mice (6 weeks of age) were obtained from Japan SLC Inc. (Hamamatsu, Japan). All experiments were performed under the guidelines for animal experimentation set by Sapporo Medical University. Adenoviral Vectors Adex1CAICOSIg containing...

... degeneration despite enduring visual improvement. Proc Natl Acad Sci U S A 2013;110:E517-E525. 13. Cepko C, Vandenberghe LH: Retinal gene therapy coming of age. Hum Gene Ther 2013;24:242-244. 14. Campochiaro PA, Nguyen QD, Shah SM, Klein ML, Holz E, Frank RN, et al: Adenoviral vector-delivered pigment...

... and application of oncolytic HSV vectors for glioblastoma therapy. Expert Rev Neurother 2009;9:505-517. 11. Russell SJ, Peng KW, Bell JC: Oncolytic virotherapy. Nat Biotechnol 2012;30:658-670. 12. Nandi S, Lesniak MS: Adenoviral virotherapy for malignant brain tumors. Expert Opin Biol Ther 2009;9:737-747...

.... Richardson GP, de Monvel JB, Petit C: How the genetics of deafness illuminates auditory physiology. Annu Rev Physiol 2011;73:311-334. 15. Campos SK, Barry MA: Current advances and future challenges in adenoviral vector biology and targeting. Curr Gene Ther 2007;7:189-204. 16. Lentz TB, Gray SJ...

... Studies in Insulin-Secreting Cells To assess whether the modification of UCP2 activity observed in patients 1 and 2 could affect insulin secretion by beta-cells, we subjected an insulin-secreting pancreatic insulinoma cell line (INS-1E) to adenoviral expression of wild-type and mutated UCP2...

..., Burbelo PD, Citrin DE, Mitchell JB, Nottingham LK, Rudy SF, Van Waes C, Whatley MA, Brahim JS, Chiorini JA, Danielides S, Turner RJ, Patronas NJ, Chen CC, Nikolov NP, Illei GG: Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction. Proc Natl...

... 2011;3:110fs10. 7. Kishimoto H, Zhao M, Hayashi K, Urata Y, Tanaka N, Fujiwara T, Penman S, Hoffman RM: In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation. Proc Natl Acad Sci USA 2009;106:14514-14517. 8. Nguyen QT, Olson ES, Aguilera TA...

..., Song X, Zhou JL, Old LJ, Crystal RG, et al: Tumor necrosis factor alpha plays a central role in immune-mediated clearance of adenoviral vectors. Proc Natl Acad Sci USA 1997;94:9814-9819 27. Sweeney SE, Mo L, Firestein GS: Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon...

...: Guralnik JM: Relationship of plasmAPolyunsaturated fatty acids to circulating inflammatory markers. J Clin Endocrinol Metab 2006;91:439-446 70. Kang ZB, Ge Y, Chen Z, Brown J, Lapasota M, Leaf A, Kang JX: Adenoviral transfer of Caenorhabditis elegans n-3 fatty acid desaturase optimizes fatty acid...

... D, Della Rocca C, Giannetti P, D'Arrigo R, Liberatoscioli L, Franlin LL, Sandig V, Ciliberto G, La Monica N, Savino R: An improved helper-dependent adenoviral vector allows persistent gene expression after intramuscular delivery and overcomes preexisting immunity to adenovirus. Proc Natl Acad Sci...

..., Saperstein DA, Gupta A, Stout JT, Macko J, DiBartolomeo R, Wei LL: Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial. Human Gene Ther 2006;17:167-176. 16. Kristinsson JK, Fridriksdottir H, Thorisdottir S...