...Introduction Acquired platelet disorders occur in childhood. The clinical approach to a child with a suspected acquired platelet disorder includes a careful history, a detailed physical examination, and focused laboratory investigations. Immune thrombocytopenia (ITP) is the most common...

...Introduction Acquired bleeding disorders encompass a heterogeneous group of conditions with varied and complex etiology and are typically encountered in hospitalized children with underlying infectious, cardiovascular, neoplastic, hepatic, and renal comorbidities. Diagnosis and management...

... Abstract Acquired idiopathic generalized anhidrosis (AIGA) is a sweating disorder characterized by inadequate sweating in response to heat stimuli such as high temperature, humidity, and physical exercise. Patients exhibit widespread nonsegmental hypohidrosis/anhidrosis without any apparent...

... in the maintenance of normal epithelial function has revealed that mild and variable CFTR mutations play a causative role in a number of diseases not classically associated with CF. Furthermore, recent evidence indicates that acquired defects in wild-type CFTR protein processing, endocytic recycling and function can...

.... Semin Dial 2009;22:279-286 24. Hedges SJ, et al: Evidence-based treatment recommendations for uremic bleeding. Nat Clin Pract Nephrol 2007;3:138-153 25. Collins PW, et al: Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre...

... or the adipose transcription factor PPARΓ. Importantly, lamin A/Cmutations are also responsible for metabolic laminopathies, resembling the metabolic syndrome and progeria, a syndrome of premature aging. A number of lipodystrophic patients remain undiagnosed at the genetic level. Acquired lipodystrophy can...

... and the indications for endoscopy with regard to the upper airways. The main focus is on the aetiology, frequency, endoscopic appearance and typical clinical presentation of important congenital and acquired abnormalities of the nose, pharynx and larynx. The nasopharyngeal lesions discussed include choanal stenosis...

... studies exist that clearly describe how to interpret and classify structural abnormalities of the bronchial tree and quantify their contribution to clinical respiratory pathology. In this chapter, we try to describe the main congenital and acquired abnormalities of the lower airways as they appear...

... Abstract Acquired hemophilia A is a rare immune coagulopathy causing life- or limb-threatening bleeding episodes.Responsible autoantibody inhibitors against factor VIII coagulant protein appear spontaneouslyin subjects with previously normal hemostatic function. Despite the fact that hemostatic...

... diathesis. Consequently,in contrast to inherited platelet disorders, acquired platelet function defects are much more frequentin clinical practice and therefore deserve special attention. Their pathogenesis is widespread and heterogeneouswith various, sometimes overlapping abnormalities in the same clinical...

... Abstract Pulmonary alveolar proteinosis (PAP) is a rare disordercharacterized by abundant deposition of surfactant-like materialin the aveoli. In this article we focus the discussion on theprimary acquired (idiopathic) PAP. We report the studies thatdeveloped the concept that this disorder...