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aberrant

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Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324607
EISBN: 978-3-8055-9723-4
...-respiratory tract infection. Clinical and laboratory data support a postulated extrarenal origin of the glomerular IgA1, likely derived from circulating immune complexes containing polymeric IgA1, deficient in galactose in the hinge-region O -glycans, bound by antiglycan antibodies. This aberrant IgA1...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324609
EISBN: 978-3-8055-9723-4
... Abstract Human IgA1, which is the predominant subtype deposited in the glomeruli in IgA nephropathy (IgAN), has a unique mucin-like structure in its hinge region. Several studies suggested that the IgA1 molecules in IgAN patients had an aberrant structure of O-glycans. The paper summarizes...
Book Chapter
Book Chapter
Series: Contributions to Nephrology
Volume: 157
Published: 25 May 2007
10.1159/000102455
EISBN: 978-3-318-01467-9
... aberrancy exposes N-acetylgalactosamine-containing neoepitopes recognized by naturallyoccurring IgG or IgA1 antibodies resulting in formation of immune complexes. IgA1 containsup to six O-glycosylation sites per heavy chain; it is not known whether the glycosylation defectoccurs randomly or preferentially...
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