... Abstract The level of food restriction that results in life extension and retarded aging in rodentsalso enhances their ability to cope with intense stressors. Moreover, this level of dietaryrestriction (DR) leads to a modest increase in the daily peak concentration of plasma freecorticosterone...

... that metabolic reprogramming is the key event in themechanism of dietary restriction, and the physiological effects at the cellular, tissue andorganismal level may be understood in terms of this initial event. ...

... Abstract Elevated blood glucose associated with diabetes produces progressive and apparentlyirreversible damage to many cell types. Conversely, reduction of glucose extends life span inyeast, and dietary restriction reduces blood glucose. Therefore it has been hypothesized thatcumulative toxic...

... characteristics of genetically normal animals subjected to dietary restriction(DR). Interestingly, DR leads to further increases in insulin sensitivity and longevity in Amesdwarfs but not in GHRKO mice. It was therefore of interest to examine the effects of DR onthe expression of insulin-related genes...

... Abstract Dietary restriction (DR) remains the most powerful and general environmental manipulationof aging processes in laboratory animals with strong beneficial effects on most agerelateddegenerative changes throughout the body. Underlying the beneficial effects of DR isthe attenuation...

... that dietary restriction (DR) has not been extensively studiedusing C. elegans. The main reason for this is the lack of an ideal method to subject C. elegansto DR. However, several authors have tried to study the effect of DR on the metabolism andphysiology of C. elegans, and epistasis-type interaction studies...

... Abstract Dietary restriction (DR) has been shown to benefit health and longevity in a wide varietyof species, although most have maximal life spans of only a few years. In 1987, theNational Institute on Aging began the first well-controlled long-term study in a species witha considerably longer...

... Abstract Long-term dietary restriction (DR) robustly inhibits various types of carcinogenesis inrodents. Because malignancies are a major cause of death in humans, reducing the incidenceor, at least, delaying the time of onset of neoplasia may significantly increase longevity of alarge...

... or even reverse features of AD. Most remarkably,while we found that high caloric intake based on saturated fat promotes AD typeΒ-amyloidosis, conversely we found that dietary restriction based on reduced carbohydrateintake is able to prevent it. This evidence is very exciting and is, in part, consistent...

... approximately 1–3 kg, and the effects of physical activity on weight loss appear to be additive to what is observed with dietary restriction alone. Moreover, physical activity is an important behavior for prevention of weight regain and maintenance of significant weight loss resulting from dietary restriction...