New high-precision technologies for the planning and delivery of radiotherapy are major advances in cancer treatment. This volume is a comprehensive guidebook to these new technologies and the many clinical treatment programs that bring them into practical use. Advances in intensity modulated radiation therapy (IMRT), 4D and adaptive treatment planning are clearly explained, and the new target localization and image-guided radiotherapy (IGRT) systems are comprehensively reviewed. Clinical tutorials fully illustrate the target definitions for the major cancer sites, and techniques for organ motion management are shown. In addition, chapters explore the technical basis for stereotactic body radiotherapy (SBRT) and the latest clinical experience with it for most organ sites. In this volume, foremost authorities explain the important new techniques and technologies of radiation oncology, and give essential treatment guidelines for its clinical and technical practitioners. (A Karger "Publishing Highlights 1890–2015" title)
IV. SBRT Clinical Treatment Programs: Stereotactic Body Radiotherapy for Unresectable Pancreatic Cancer
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Published:2007
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Book Series: Frontiers of Radiation Therapy and Oncology
Stephanie T. Chang, Karyn A. Goodman, George P. Yang, Albert C. Koong, 2007. "Stereotactic Body Radiotherapy for Unresectable Pancreatic Cancer", IMRT, IGRT, SBRT - Advances in the Treatment Planning and Delivery of Radiotherapy, J.L. Meyer, B.D. Kavanagh, J.A. Purdy, R. Timmerman
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Abstract
Pancreatic cancer is a devastating disease with few effective treatment modalities. Recent technological advances have made possible the delivery of single-fraction stereotactic body radiotherapy (SBRT) to patients with locally advanced pancreatic tumors. This paper presents experience at Stanford University with SBRT for patients with unresectable pancreatic cancer. Pancreatic tumors of up to 100 cm3 could be treated. Patients achieved greater than 90% local control for the remainder of their lives. Currently, the standard dose for pancreatic tumors treated at this institution is 25 Gy given in a single fraction. Four-dimensional CT and PET scans have been essential for optimal treatment planning. PET-CT scanning may be a more effective method for evaluating tumor response than conventional CT scanning. Adjuvant systemic therapies could be administered in coordination with SBRT. SBRT is an effective method of treating patients resulting in excellent local control. Current research is aimed at defining the optimal method of combining this treatment with other cancer therapies.
