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Frontiers of Neurology and Neuroscience
The Orexin System. Basic Science and Role in Sleep Pathology
S.Karger AG
Volume
45
Status:
Available
ISBN electronic:
978-3-318-06844-3
ISBN print:
978-3-318-06843-6
Book Series:
Frontiers of Neurology and Neuroscience
Publication date:
2021
Book Details
The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system.
This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.
The Orexin System. Basic Science and Role in Sleep Pathology
Edited by: Michel A. Steiner, Masashi Yanagisawa, Martine Clozel
https://doi.org/10.1159/isbn.978-3-318-06844-3
ISBN (print): 978-3-318-06843-6
ISBN (electronic): 978-3-318-06844-3
Publisher: S.Karger AG
Published: 2021
Download citation file:
Print Version
The Orexin System. Basic Science and Role in Sleep Pathology
$39.00
Table of Contents
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1 - 10: Twenty-Three Years of Hypocretins: The “Rosetta Stone” of Sleep/Arousal CircuitsByLuis de LeceaLuis de LeceaDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USASearch for other works by this author on:
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11 - 21: Interaction between Orexin Neurons and Monoaminergic SystemsByTakeshi Sakurai;Takeshi SakuraiaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, JapanbFaculty of Medicine, University of Tsukuba, Tsukuba, JapanSearch for other works by this author on:Yuki C. Saito;Yuki C. SaitoaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, JapanSearch for other works by this author on:Masashi YanagisawaMasashi YanagisawaaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, JapanSearch for other works by this author on:
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22 - 37: Hypocretin/Orexin Receptor Pharmacology and Sleep PhasesByYu Sun;Yu SunCenter for Neuroscience, Biosciences Division, SRI International, Menlo Park, California, USASearch for other works by this author on:Ryan K. Tisdale;Ryan K. TisdaleCenter for Neuroscience, Biosciences Division, SRI International, Menlo Park, California, USASearch for other works by this author on:Thomas S. KilduffThomas S. KilduffCenter for Neuroscience, Biosciences Division, SRI International, Menlo Park, California, USASearch for other works by this author on:
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38 - 51: Sleep, Orexin and CognitionByBalmeet Toor;Balmeet TooraSchool of Psychology, University of Ottawa, Ottawa, Ontario, CanadaSearch for other works by this author on:Laura B. Ray;Laura B. RayaSchool of Psychology, University of Ottawa, Ottawa, Ontario, CanadabSleep Unit, The Royal’s Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, CanadaSearch for other works by this author on:Alyssa Pozzobon;Alyssa PozzobonaSchool of Psychology, University of Ottawa, Ottawa, Ontario, CanadaSearch for other works by this author on:Stuart M. FogelStuart M. FogelaSchool of Psychology, University of Ottawa, Ottawa, Ontario, CanadabSleep Unit, The Royal’s Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, CanadacUniversity of Ottawa Brain and Mind Research Institute, Ottawa, Ontario, CanadaSearch for other works by this author on:
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52 - 60: Subsecond Ensemble Dynamics of Orexin Neurons Link Sensation and ActionByDenis BurdakovDenis BurdakovDepartment of Health Sciences and Technology, ETH Zürich, Zürich, SwitzerlandSearch for other works by this author on:
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61 - 74: Heterogeneity of Hypocretin/Orexin NeuronsByDana Sagi;Dana SagiaThe Faculty of Life Sciences and the Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, IsraelSearch for other works by this author on:Luis de Lecea;Luis de LeceabDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USASearch for other works by this author on:Lior AppelbaumLior AppelbaumaThe Faculty of Life Sciences and the Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, IsraelSearch for other works by this author on:
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75 - 90: Sleep and Metabolism: Implication of Lateral Hypothalamic NeuronsByLukas T. Oesch;Lukas T. OeschaZentrum für Experimentelle Neurologie, Department of Neurology, Inselspital University Hospital Bern, Bern, SwitzerlandbDepartment of Biomedical Research, University of Bern, Bern, SwitzerlandSearch for other works by this author on:Antoine R. AdamantidisAntoine R. AdamantidisaZentrum für Experimentelle Neurologie, Department of Neurology, Inselspital University Hospital Bern, Bern, SwitzerlandbDepartment of Biomedical Research, University of Bern, Bern, SwitzerlandSearch for other works by this author on:
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91 - 102: Cellular Signaling Mechanisms of Hypocretin/OrexinByJyrki P. Kukkonen;Jyrki P. KukkonenDepartment of Pharmacology and Department of Physiology, Institute of Biomedicine, Faculty of Medicine, University of Helsinki, Helsinki, FinlandSearch for other works by this author on:Pauli M. TurunenPauli M. TurunenDepartment of Pharmacology and Department of Physiology, Institute of Biomedicine, Faculty of Medicine, University of Helsinki, Helsinki, FinlandSearch for other works by this author on:
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103 - 116: Sleep Problems in Narcolepsy and the Role of Hypocretin/Orexin DeficiencyByEmmanuel Mignot;Emmanuel MignotaCenter for Narcolepsy, Stanford University, Palo Alto, California, USASearch for other works by this author on:Jamie Zeitzer;Jamie ZeitzeraCenter for Narcolepsy, Stanford University, Palo Alto, California, USASearch for other works by this author on:Fabio Pizza;Fabio PizzabDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, ItalycIRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalySearch for other works by this author on:Giuseppe PlazziGiuseppe PlazzicIRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalydDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio-Emilia, Modena, ItalySearch for other works by this author on:
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117 - 127: The Insomnia-Addiction Positive Feedback Loop: Role of the Orexin SystemByJennifer E. Fragale;Jennifer E. FragaleaBrain Health Institute, Rutgers Biomedical Health Sciences, Rutgers University, Piscataway, New Jersey, USASearch for other works by this author on:Morgan H. James;Morgan H. JamesaBrain Health Institute, Rutgers Biomedical Health Sciences, Rutgers University, Piscataway, New Jersey, USASearch for other works by this author on:Jorge A. Avila;Jorge A. AvilaaBrain Health Institute, Rutgers Biomedical Health Sciences, Rutgers University, Piscataway, New Jersey, USASearch for other works by this author on:Andrea M. Spaeth;Andrea M. SpaethbDepartment of Kinesiology and Health, Rutgers University, New Brunswick, New Jersey, USASearch for other works by this author on:R. Nisha Aurora;R. Nisha AuroracDepartment of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USASearch for other works by this author on:Daniel Langleben;Daniel LanglebendDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USASearch for other works by this author on:Gary Aston-JonesGary Aston-JonesaBrain Health Institute, Rutgers Biomedical Health Sciences, Rutgers University, Piscataway, New Jersey, USASearch for other works by this author on:
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128 - 138: Causes and Consequences of Chronic Sleep Deficiency and the Role of OrexinByJanet M. Mullington;Janet M. MullingtonaDepartment of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USASearch for other works by this author on:Tony J. Cunningham;Tony J. CunninghambDepartment of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USAcDepartment of Psychology and Neuroscience, Boston College, Boston, Massachusetts, USASearch for other works by this author on:Monika Haack;Monika HaackaDepartment of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USASearch for other works by this author on:Huan YangHuan YangaDepartment of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USASearch for other works by this author on:
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139 - 149: Hypocretin/Orexin, Sleep and Alzheimer’s DiseaseByYves DauvilliersYves DauvilliersaNational Reference Centre for Orphan Diseases, Narcolepsy – Rare Hypersomnias, Sleep Unit, Department of Neurology, CHU Montpellier, University of Montpellier, Montpellier, FrancebInstitute for Neurosciences of Montpellier INM, University of Montpellier, INSERM, Montpellier, FranceSearch for other works by this author on:
