Endocrine and Metabolic Late Effects in Cancer Survivors
This book analyzes in detail all aspects related to endocrine and metabolic late effects observed in patients treated for cancer, both in childhood and adulthood. The chapters focusing on the possible pathogenic mechanisms of late effects (i.e., premature aging and chronic inflammation) and on bone health in cancer survivors are particularly interesting and innovative. The volume also deals with hypothalamic-pituitary, thyroid and gonadal disorders, including infertility and how to prevent it. Finally, the relationship between metabolic alterations and cardiovascular diseases in cancer survivors is addressed. Thanks to advances in cancer treatment and supportive care, the five-year survival rate of cancer patients is constantly increasing. However, this undisputable success of medicine has a flip side: the late adverse effects of anticancer therapies. Pediatric oncologists were the first to cope with late complications of treatments, but today also adult oncologists and onco-hematologists recognize the relevance of this issue. Even though late effects observed in cancer survivors can affect any organ or system, endocrine and metabolic dysfunctions are the most frequently reported. Endocrine complications rarely influence life expectancy of cancer survivors, but they can significantly impact morbidity and quality of life. Among endocrine adverse effects, severe hypothalamic damage may be considered the most harmful in survivors, leading to morbid obesity, propensity to metabolic syndrome and cardiovascular disease. This book aims to disseminate the knowledge about endocrine and metabolic adverse effects of cancer therapies and about survivorship care. Since the number of cancer survivors is steadily growing in the general population, this publication is intended not only for endocrinologists but also for oncologists, onco-hematologists, internists, pediatric specialists in those areas and general practitioners, with the aim to better counsel and monitor cancer survivors.
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The Concept of Cancer Survivorship and Models for Long-Term Follow-UpByRebecca J. van Kalsbeek;Rebecca J. van KalsbeekaPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
* Search for other works by this author on:Renée L. Mulder;Renée L. MulderaPrincess Máxima Center for Pediatric Oncology, Utrecht, The NetherlandsSearch for other works by this author on:Roderick Skinner;Roderick SkinnerbGreat North Children’s Hospital, and Clinical and Translational Research Institute, and Newcastle University Centre for Cancer, Newcastle upon Tyne, UKSearch for other works by this author on:Leontien C.M. KremerLeontien C.M. KremeraPrincess Máxima Center for Pediatric Oncology, Utrecht, The NetherlandsSearch for other works by this author on: -
Accelerated Aging as a Paradigm to Understand the Late Effects of Cancer TherapiesBySaskia Martine Francesca PluijmSaskia Martine Francesca PluijmPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Growth Hormone Deficiency and Growth Hormone Replacement in Childhood Cancer SurvivorsByBriana C. Patterson;Briana C. PattersonaAflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University, Children’s Healthcare of Atlanta, Atlanta, GA, USAbDivision of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Emory University, Children’s Healthcare of Atlanta, Atlanta, GA, USA
* Search for other works by this author on:Lillian R. MeachamLillian R. MeachamaAflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University, Children’s Healthcare of Atlanta, Atlanta, GA, USASearch for other works by this author on: -
Hypothalamic-Pituitary Dysfunctions Other Than Growth Hormone Deficiency in Cancer SurvivorsByLaura van Iersel;Laura van IerselaDepartment of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The NetherlandsSearch for other works by this author on:Wassim ChemaitillyWassim ChemaitillybDivision of Endocrinology, Department of Pediatric Medicine, St. Jude Children’s Research Hospital, Memphis, TN, USAcDepartment of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, Memphis, TN, USA
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Hypothalamic-Pituitary Outcome after Treatment for Childhood CraniopharyngiomaByJiska van Schaik;Jiska van SchaikaDepartment of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The NetherlandsbDepartment of Neuro-Oncology, Princess Maxima Center for Pediatric Oncology, Utrecht, The NetherlandsSearch for other works by this author on:Eelco W. Hoving;Eelco W. HovingbDepartment of Neuro-Oncology, Princess Maxima Center for Pediatric Oncology, Utrecht, The NetherlandsSearch for other works by this author on:Hermann L. Müller;Hermann L. MüllercDepartment of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Klinikum Oldenburg AöR, Oldenburg, GermanySearch for other works by this author on:Hanneke M. van SantenHanneke M. van SantenaDepartment of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The NetherlandsbDepartment of Neuro-Oncology, Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Gonadal Failure and Infertility in Cancer Survivors: Clinical Management and Strategies for PreventionByMarco Zavattaro;Marco ZavattaroaDivision of Endocrinology, Department of Translational Medicine, University of Eastern Piedmont, Novara, ItalybDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalySearch for other works by this author on:Fabio Lanfranco;Fabio LanfrancocDivision of Endocrinology, Andrology and Metabolism, Humanitas Gradenigo Hospital, Department of Medical Sciences, University of Turin, Turin, Italy
* Search for other works by this author on:Francesca Salvagno;Francesca SalvagnodDivision of Obstetrics and Gynaecology, Physiopathology of Reproduction and IVF Unit, Sant’Anna Hospital, University of Turin, Turin, ItalySearch for other works by this author on:Giovanna Motta;Giovanna MottabDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalySearch for other works by this author on:Marta Sestero;Marta SesterodDivision of Obstetrics and Gynaecology, Physiopathology of Reproduction and IVF Unit, Sant’Anna Hospital, University of Turin, Turin, ItalySearch for other works by this author on:Lorenzo Marinelli;Lorenzo MarinellibDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalySearch for other works by this author on:Stefano Canosa;Stefano CanosadDivision of Obstetrics and Gynaecology, Physiopathology of Reproduction and IVF Unit, Sant’Anna Hospital, University of Turin, Turin, ItalySearch for other works by this author on:Alberto RevelliAlberto RevellidDivision of Obstetrics and Gynaecology, Physiopathology of Reproduction and IVF Unit, Sant’Anna Hospital, University of Turin, Turin, ItalySearch for other works by this author on: -
Beyond Bone Mineral Density: The Impact of Childhood Cancer and Its Treatment on Bone Structure and StrengthByMelissa Fiscaletti;Melissa FiscalettiaSainte Justine University Hospital and Research Centre, Department of Pediatrics, University of Montreal, Montreal, QC, CanadaSearch for other works by this author on:Nathalie Alos;Nathalie AlosaSainte Justine University Hospital and Research Centre, Department of Pediatrics, University of Montreal, Montreal, QC, CanadaSearch for other works by this author on:Leanne M. WardLeanne M. WardbChildren’s Hospital of Eastern Ontario, Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada
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Cancer Treatment-Induced Bone Loss in Hormone-Sensitive Cancer: The Paradigm of Cancer Survivor Bone Health ManagementByNicoletta Fortunati;Nicoletta FortunatiaSSD Unità di Transizione per Neoplasie Trattate in Età Pediatrica, Turin, ItalybSCDU Endocrinologia Oncologica, AOU Città della Salute e della Scienza di Torino, Turin, Italy
* Search for other works by this author on:Filippo Gatti;Filippo GattiaSSD Unità di Transizione per Neoplasie Trattate in Età Pediatrica, Turin, ItalySearch for other works by this author on:Francesco Felicetti;Francesco FelicettiaSSD Unità di Transizione per Neoplasie Trattate in Età Pediatrica, Turin, ItalySearch for other works by this author on:Enrico BrignardelloEnrico BrignardelloaSSD Unità di Transizione per Neoplasie Trattate in Età Pediatrica, Turin, ItalySearch for other works by this author on: -
Diabetes in Cancer Patients: Risks, Goals and ManagementByAlberto Ragni;Alberto RagniaOncological Endocrinology Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza Hospital, Turin, ItalySearch for other works by this author on:Francesca Retta;Francesca RettaaOncological Endocrinology Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza Hospital, Turin, ItalySearch for other works by this author on:Emanuela Arvat;Emanuela ArvataOncological Endocrinology Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza Hospital, Turin, ItalySearch for other works by this author on:Marco GalloMarco GalloaOncological Endocrinology Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza Hospital, Turin, ItalybEndocrinology and Metabolic Diseases Unit, AO S.S. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
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Cardiometabolic Risk, Part 1: Chemotherapy and Radiotherapy – Old Foes Still Threatening Cancer Survivors?ByMaja Vestmø Maraldo;Maja Vestmø MaraldoaDepartment of Clinical Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, DenmarkSearch for other works by this author on:Alessandro Andreis;Alessandro AndreisbDivision of Cardiology, Department of Medical Sciences, Città della Salute e della Scienza di Torino Hospital, University of Turin, Turin, ItalySearch for other works by this author on:Ilenia Iamundo de Cumis;Ilenia Iamundo de CumiscUOC Radioterapia Oncologica, Azienda Ospedaliera “Brotzu”, Cagliari, ItalySearch for other works by this author on:Marzia Cerrato;Marzia CerratodDepartment of Oncology, University of Torino, Torino, ItalySearch for other works by this author on:Angelisa Vella;Angelisa VelladDepartment of Oncology, University of Torino, Torino, ItalySearch for other works by this author on:Umberto Ricardi;Umberto RicardidDepartment of Oncology, University of Torino, Torino, ItalySearch for other works by this author on:Mario LevisMario LevisdDepartment of Oncology, University of Torino, Torino, Italy
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Cardiometabolic Risk, Part 2: Indirect Cardiotoxicity in Cancer Survivors – The Emerging Role of Metabolic SyndromeByFrancesco Felicetti;Francesco FelicettiaTransition Unit for Childhood Cancer Survivors, Città della Salute e della Scienza Hospital, Turin, Italy
* Search for other works by this author on:Enrico Brignardello;Enrico BrignardelloaTransition Unit for Childhood Cancer Survivors, Città della Salute e della Scienza Hospital, Turin, ItalySearch for other works by this author on:Janine NuverJanine NuverbMedical Oncology, University Medical Center, Groningen, The NetherlandsSearch for other works by this author on: -
Thyroid Dysfunction and Thyroid Cancer in Childhood Cancer Survivors: Prevalence, Surveillance and ManagementByChantal A. Lebbink;Chantal A. LebbinkaDepartment of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The NetherlandsbPrincess Máxima Center for Pediatric Oncology, Utrecht, The NetherlandsSearch for other works by this author on:Steven G. Waguespack;Steven G. WaguespackcDepartment of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, USASearch for other works by this author on:Hanneke M. van SantenHanneke M. van SantenaDepartment of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The NetherlandsbPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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