Vaccines for Older Adults: Current Practices and Future Opportunities
Many infectious diseases are more frequent and are associated with high morbidity and mortality in older adults. Vaccination is the most efficient strategy to prevent infections, and older adults are an important target population for vaccination in order to promote health in this age group. Age-related changes in the immune system as well as other factors, such as comorbidities, obesity or frailty, influence vaccine-induced immune responses in old age. Awareness that vaccines developed for children might not be optimal for adults, and particularly for the older population, has only arisen in the recent past. Vaccination against influenza, pneumococcal disease, and herpes zoster is specifically recommended for older adults in many countries, and various strategies have been pursued in order to optimize these vaccines. However, there are still many pathogens, which severely affect the older population, but for which no vaccines are currently available. Extensive research and development are ongoing to further improve existing vaccines and to design novel vaccines in order to provide protection for this vulnerable age group. In order to exploit the full protective potential of vaccines it is essential to improve vaccine uptake and overcome vaccine hesitancy by providing information and education to stakeholders, health care professionals, and the general public.
This book is relevant for researchers working on age-related changes in the immune system or on vaccine development, for health care professionals treating older patients, and for the stakeholders and decision makers involved in vaccination recommendations and implementation.
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Table of Contents
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1 - 17: How Inflammation Blunts Innate Immunity in AgingByEmily L. Goldberg;Emily L. GoldbergaDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USASearch for other works by this author on:Albert C. Shaw;Albert C. ShawbDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USASearch for other works by this author on:Ruth R. MontgomeryRuth R. MontgomerybDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USASearch for other works by this author on:
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18 - 35: Natural Killer Cells, Aging, and VaccinationByJacek M. Witkowski;Jacek M. WitkowskiaDepartment of Pathophysiology, Medical University of Gdansk, Gdansk, PolandSearch for other works by this author on:Anis Larbi;Anis LarbibSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Singapore, SingaporecDepartment of Biology, Faculty of Science, University of Tunis El Manar, Tunis, TunisiaSearch for other works by this author on:Aurélie Le Page;Aurélie Le PagedResearch Center on Aging, Graduate Program in Immunology, Faculty of Medicine and Health Sciences, Department of Medicine, University of Sherbrooke, Sherbrooke, Québec, CanadaSearch for other works by this author on:Tamàs FülöpTamàs FülöpdResearch Center on Aging, Graduate Program in Immunology, Faculty of Medicine and Health Sciences, Department of Medicine, University of Sherbrooke, Sherbrooke, Québec, CanadaSearch for other works by this author on:
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36 - 55: Changes in T Cell Homeostasis and Vaccine Responses in Old AgeByGlenn Choon Lim Wong;Glenn Choon Lim WongaSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos, Singapore, SingaporeSearch for other works by this author on:Marie Clare Strickland;Marie Clare StricklandaSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos, Singapore, SingaporebClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United KingdomSearch for other works by this author on:Anis LarbiAnis LarbiaSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos, Singapore, SingaporecDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporedGeriatrics Division, Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Québec, CanadaeDepartment of Biology, Faculty of Sciences, University Tunis El Manar, Tunis, TunisiaSearch for other works by this author on:
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56 - 72: Age-Related Changes in B Cells Relevant to Vaccine ResponsesByDeborah K. Dunn-Walters;Deborah K. Dunn-WaltersSchool of Biosciences and Medicine, University of Surrey, Guildford, United KingdomSearch for other works by this author on:Alexander T. Stewart;Alexander T. StewartSchool of Biosciences and Medicine, University of Surrey, Guildford, United KingdomSearch for other works by this author on:Emma L. Sinclair;Emma L. SinclairSchool of Biosciences and Medicine, University of Surrey, Guildford, United KingdomSearch for other works by this author on:Ilaria SerangeliIlaria SerangeliSchool of Biosciences and Medicine, University of Surrey, Guildford, United KingdomSearch for other works by this author on:
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73 - 85: Comorbidities in the Elderly and Their Possible Influence on Vaccine ResponseByAnja Kwetkat;Anja KwetkataDepartment of Geriatric Medicine, Jena University Hospital, Jena, GermanySearch for other works by this author on:Hans Jürgen HeppnerHans Jürgen HeppnerbFaculty of Health, Witten/Herdecke University, Witten, GermanycDepartment of Geriatric Medicine, HELIOS Klinikum Schwelm, Schwelm, GermanySearch for other works by this author on:
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86 - 97: The Impact of Obesity and Metabolic Syndrome on Vaccination SuccessByDaniela Frasca;Daniela FrascaaDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USASearch for other works by this author on:Bonnie B. BlombergBonnie B. BlombergaDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USAbSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, USASearch for other works by this author on:
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98 - 112: Influenza Vaccination: Accelerating the Process for New Vaccine Development in Older AdultsByJanet E. McElhaney;Janet E. McElhaneyaHealth Sciences North Research Institute, Sudbury, Ontario, CanadaSearch for other works by this author on:Melissa K. Andrew;Melissa K. AndrewbDepartment of Medicine and Canadian Center for Vaccinology, Dalhousie University, Halifax, Nova Scotia, CanadaSearch for other works by this author on:Laura Haynes;Laura HaynescUniversity of Connecticut Center on Aging, UConn Health Center, Farmington, Connecticut, USASearch for other works by this author on:George A. Kuchel;George A. KuchelcUniversity of Connecticut Center on Aging, UConn Health Center, Farmington, Connecticut, USASearch for other works by this author on:Shelly A. McNeil;Shelly A. McNeilbDepartment of Medicine and Canadian Center for Vaccinology, Dalhousie University, Halifax, Nova Scotia, CanadaSearch for other works by this author on:Graham PawelecGraham PawelecaHealth Sciences North Research Institute, Sudbury, Ontario, CanadadDepartment of Immunology, University of Tübingen, Tübingen, GermanySearch for other works by this author on:
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113 - 130: Vaccines to Protect Older Adults against Pneumococcal DiseaseByMartijn D.B. van de Garde;Martijn D.B. van de GardeCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The NetherlandsSearch for other works by this author on:Mirjam J. Knol;Mirjam J. KnolCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The NetherlandsSearch for other works by this author on:Nynke Y. Rots;Nynke Y. RotsCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The NetherlandsSearch for other works by this author on:Debbie van Baarle;Debbie van BaarleCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The NetherlandsSearch for other works by this author on:Cécile A.C.M. van ElsCécile A.C.M. van ElsCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The NetherlandsSearch for other works by this author on:
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131 - 145: Herpes Zoster and Its Prevention by VaccinationByRobert W. Johnson;Robert W. JohnsonaFaculty of Health Sciences, University of Bristol, Bristol, United KingdomSearch for other works by this author on:Myron J. LevinMyron J. LevinbUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USASearch for other works by this author on:
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146 - 157: Vaccination of Adults and the Older Population against Tetanus, Diphtheria, Pertussis, and Tick-Borne Encephalitis: The Importance of Booster Vaccinations throughout LifeByBirgit WeinbergerBirgit WeinbergerInstitute for Biomedical Aging Research, University of Innsbruck, Innsbruck, AustriaSearch for other works by this author on:
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158 - 181: Vaccines for Older TravelersByWolfgang JilgWolfgang JilgInstitute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, GermanySearch for other works by this author on:
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182 - 192: Vaccination against Respiratory Syncytial VirusByChristopher A. Green;Christopher A. GreenaOxford Vaccine Group, Department of Paediatrics and the NIHR Oxford, Biomedical Research Centre, University of Oxford, Oxford, United KingdomdInstitute of Microbiology and Infection, University of Birmingham, Birmingham, United KingdomSearch for other works by this author on:Simon B. Drysdale;Simon B. DrysdaleaOxford Vaccine Group, Department of Paediatrics and the NIHR Oxford, Biomedical Research Centre, University of Oxford, Oxford, United KingdombInstitute for Infection and Immunity, Paediatric Infectious Diseases Research Group, St George’s, University of London, London, United KingdomSearch for other works by this author on:Andrew J. Pollard;Andrew J. PollardaOxford Vaccine Group, Department of Paediatrics and the NIHR Oxford, Biomedical Research Centre, University of Oxford, Oxford, United KingdomSearch for other works by this author on:Charles J. SandeCharles J. SandeaOxford Vaccine Group, Department of Paediatrics and the NIHR Oxford, Biomedical Research Centre, University of Oxford, Oxford, United KingdomcKEMRI-Wellcome Trust Research Programme, Kilifi, KenyaSearch for other works by this author on:
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193 - 217: Vaccination against Nosocomial Infections in Elderly AdultsByAnnaliesa S. Anderson;Annaliesa S. AndersonPfizer Vaccine Research & Development, Pearl River, New York, USASearch for other works by this author on:Ingrid L. Scully;Ingrid L. ScullyPfizer Vaccine Research & Development, Pearl River, New York, USASearch for other works by this author on:Michael W. Pride;Michael W. PridePfizer Vaccine Research & Development, Pearl River, New York, USASearch for other works by this author on:Kathrin U. JansenKathrin U. JansenPfizer Vaccine Research & Development, Pearl River, New York, USASearch for other works by this author on:
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218 - 233: Novel Technologies to Improve Vaccines for Older AdultsByRobbert van der Most;Robbert van der MostaGSK, Wavre, BelgiumSearch for other works by this author on:Giuseppe Del GiudiceGiuseppe Del GiudicebGSK, Siena, ItalySearch for other works by this author on:
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234 - 248: Strategies to Improve Vaccine Uptake throughout AdulthoodByFiona Ecarnot;Fiona EcarnotaEA3920, University of Franche-Comté, Besançon, FrancebUniversity Hospital Jean Minjoz, Besançon, FranceSearch for other works by this author on:Stefania Maggi;Stefania MaggicCNR Institute of Neuroscience, Aging Branch, Padua, ItalySearch for other works by this author on:Jean-Pierre MichelJean-Pierre MicheldUniversity of Geneva, Geneva, SwitzerlandSearch for other works by this author on: