Milk, Mucosal Immunity and the Microbiome: Impact on the Neonate: 94th Nestlé Nutrition Institute workshop, Lausanne, September 2019
Considerable advances have been made in science in order to understand the varied mixture of bioactive components in human milk. The 94th Nestlé Nutrition Institute Workshop was designed to provide a comprehensive overview of the latest findings in human milk research and its potential to modulate mucosal immunity, the microbiome, and its impact on the neonate.
The publication provides a balanced state-of-the-art update on the current knowledge about milk, mucosal immunity, and the microbiome as well as their impact on breastfeeding in mammalian neonates. The first part reviews data on the immunology of milk and lactation from a historical perspective to the latest scientific findings. The second part discusses the microbiology of human milk and lactation in detail, with a focus on premature infants and necrotizing enterocolitis. And finally, in the third part, light is shed on the protective factors in human milk and their role in influencing the neonate’s immune system.
Important new insights will provide great scientific support for all people seeking a deeper understanding of human milk and its immunological properties and will enlarge the knowledge of those who have already specialized in human milk research.
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Table of Contents
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1 - 10: The Evolution of Lactation in Mammalian SpeciesByOlav T. OftedalOlav T. OftedalSmithsonian Environmental Research Center, Edgewater, Maryland, USASearch for other works by this author on:
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11 - 26: Immunology of Human Milk and Lactation: Historical OverviewByPearay L. OgraPearay L. OgraDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USASearch for other works by this author on:
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27 - 37: The Mammary Gland as an Integral Component of the Common Mucosal Immune SystemByJiri MesteckyJiri MesteckyaDepartment of Microbiology and Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USAbLaboratory of Cellular and Molecular Immunology, Institute of Microbiology, Czech Academy of Sciences, Prague, CzechiaSearch for other works by this author on:
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38 - 47: Immunomodulatory Components of Human Colostrum and MilkByHelena Tlaskalová-Hogenová;Helena Tlaskalová-HogenováaInstitute of Microbiology, Czech Academy of Sciences, Prague, CzechiabInstitute of Immunology and Microbiology, 1st Faculty of Medicine, Charles University, Prague, CzechiaSearch for other works by this author on:Miloslav Kverka;Miloslav KverkaaInstitute of Microbiology, Czech Academy of Sciences, Prague, CzechiacInstitute of Experimental Medicine, Czech Academy of Sciences, Prague, CzechiaSearch for other works by this author on:Jiří HrdýJiří HrdýbInstitute of Immunology and Microbiology, 1st Faculty of Medicine, Charles University, Prague, CzechiaSearch for other works by this author on:
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48 - 58: Breastfeeding, a Personalized Medicine with Influence on Short- and Long-Term Immune HealthByValérie VerhasseltValérie VerhasseltSchool of Molecular Sciences, University of Western Australia, Perth, Washington, AustraliaSearch for other works by this author on:
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65 - 74: Milk Microbiome and Neonatal Colonization: OverviewBySamuli RautavaSamuli RautavaDepartment of Pediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, FinlandSearch for other works by this author on:
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75 - 85: Human Milk Microbiota: Origin and Potential UsesByLeónides Fernández;Leónides FernándezaDepartment of Galenic Pharmacy and Food Technology, Complutense University of Madrid, Madrid, SpainSearch for other works by this author on:Juan M. RodríguezJuan M. RodríguezbDepartment of Nutrition and Food Science, Complutense University of Madrid, Madrid, SpainSearch for other works by this author on:
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86 - 93: Beyond the Bacterial Microbiome: Virome of Human Milk and Effects on the Developing InfantBySindhu Mohandas;Sindhu MohandasaDivision of Infectious Diseases, Department of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, California, USASearch for other works by this author on:Pia S. PannarajPia S. PannarajaDivision of Infectious Diseases, Department of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, California, USAbDepartment of Molecular Immunology and Microbiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USASearch for other works by this author on:
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94 - 102: Gut Microbiota, Host Gene Expression, and Cell Traffic via MilkByJosef NeuJosef NeuDepartment of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USASearch for other works by this author on:
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103 - 112: Breast Milk and Microbiota in the Premature Gut: A Method of Preventing Necrotizing EnterocolitisByW. Allan Walker;W. Allan WalkerPediatric Gastroenterology Department, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Harvard Medical School, Boston, Massachusetts, USASearch for other works by this author on:Di MengDi MengPediatric Gastroenterology Department, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Harvard Medical School, Boston, Massachusetts, USASearch for other works by this author on:
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115 - 123: Human Milk Oligosaccharides: Structure and FunctionsByLars BodeLars BodeDivision of Neonatology and Division of Gastroenterology and Nutrition, Department of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), University of California, La Jolla, California, USASearch for other works by this author on:
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124 - 132: Oligosaccharides and Viral Infection: Human Milk Oligosaccharides versus Algal Fucan-Type PolysaccharidesByFranz-Georg Hanisch;Franz-Georg HanischaInstitute of Biochemistry II, Medical Faculty, University of Cologne, Köln, GermanySearch for other works by this author on:Cem AydoganCem AydoganbPhytoNet AG, Schindellegi-Feusisberg, SwitzerlandSearch for other works by this author on:
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133 - 140: Milk Fat Globule Membranes: Effects on Microbiome, Metabolome, and Infections in Infants and ChildrenByOlle Hernell;Olle HernellaPediatrics, Department of Clinical Sciences, Umeå University, Umeå, SwedenSearch for other works by this author on:Bo Lönnerdal;Bo LönnerdalbDepartment of Nutrition, University of California, Davis, California, USASearch for other works by this author on:Niklas TimbyNiklas TimbyaPediatrics, Department of Clinical Sciences, Umeå University, Umeå, SwedenSearch for other works by this author on:
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141 - 151: Clinical Trials of Lactoferrin in the Newborn: Effects on Infection and the Gut MicrobiomeByNicholas D. Embleton;Nicholas D. EmbletonNewcastle Neonatal Service, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United KingdomSearch for other works by this author on:Janet E. BerringtonJanet E. BerringtonNewcastle Neonatal Service, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United KingdomSearch for other works by this author on:
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152 - 157: Effects of Milk Osteopontin on Intestine, Neurodevelopment, and ImmunityByRulan Jiang;Rulan JiangDepartment of Nutrition, University of California, Davis, California, USASearch for other works by this author on:Bo LönnerdalBo LönnerdalDepartment of Nutrition, University of California, Davis, California, USASearch for other works by this author on:
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158 - 168: Effects of Milk Secretory Immunoglobulin A on the Commensal MicrobiotaByVanessa P. Dunne-Castagna;Vanessa P. Dunne-CastagnaaDepartment of Food Science and Technology, University of California, Davis, California, USAbDepartment of Nutrition, University of California, Davis, California, USASearch for other works by this author on:David A. Mills;David A. MillsaDepartment of Food Science and Technology, University of California, Davis, California, USASearch for other works by this author on:Bo LönnerdalBo LönnerdalbDepartment of Nutrition, University of California, Davis, California, USASearch for other works by this author on: