Anterior Skull Base Tumors
In recent years, interest in the management of anterior skull base tumors has been fostered by the introduction and subsequent rapid expansion of indications of transnasal endoscopic techniques. In parallel, extraordinary progress has been made in all the other disciplines which are involved in the complex process of managing anterior skull base tumors, leading to substantial improvements in diagnosis and treatment. The anterior skull base can be involved in a large variety of tumors of a varying nature and histology, which in the majority of cases originate from adjacent anatomic sites. In fact, primary lesions of the anterior skull base mainly include osteoma and other tumors originating from bone and cartilage. Tumors involving the anterior skull base have their origin prevalently in the sinonasal tract, but lesions developing on the intracranial site, such as meningiomas, may also extend caudally to encroach upon this area. All these lesions are rare, which means that the pertinent literature does not include prospective studies or treatment guidelines based on a high level of evidence. In view of the extreme histological variability of lesions involving the anterior skull base, much emphasis has been placed on addressing the different nuances of treatment in relation to histology, especially for malignant tumors. The chapters focusing on surgery provide divergent views on selection criteria for a specific surgical technique, which is the aim of this publication.
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1 - 12: Macroscopic and Endoscopic Anatomy of the Anterior Skull Base and Adjacent StructuresByMarco Ferrari;Marco FerrariaUnit of Otorhinolaryngology – Head and Neck Surgery, Department of Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, ItalybSection of Otorhinolaryngology – Head and Neck Surgery, Department of Neurosciences, University of Padua, Padua, ItalySearch for other works by this author on:Davide Mattavelli;Davide MattavelliaUnit of Otorhinolaryngology – Head and Neck Surgery, Department of Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, ItalySearch for other works by this author on:Alberto Schreiber;Alberto SchreiberaUnit of Otorhinolaryngology – Head and Neck Surgery, Department of Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, ItalySearch for other works by this author on:Piero NicolaiPiero NicolaibSection of Otorhinolaryngology – Head and Neck Surgery, Department of Neurosciences, University of Padua, Padua, ItalySearch for other works by this author on:
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13 - 27: Pathology and Differential Diagnosis of Anterior Skull Base TumoursByMichelle D. Williams;Michelle D. WilliamsDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USASearch for other works by this author on:Adel K. El-NaggarAdel K. El-NaggarDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USASearch for other works by this author on:
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28 - 45: The Role of Morphologic and Functional Imaging in Pretreatment AssessmentByRoberto Maroldi;Roberto MaroldiDepartment of Radiology, University of Brescia, Brescia, ItalySearch for other works by this author on:Andrea Borghesi;Andrea BorghesiDepartment of Radiology, University of Brescia, Brescia, ItalySearch for other works by this author on:Marco Ravanelli;Marco RavanelliDepartment of Radiology, University of Brescia, Brescia, ItalySearch for other works by this author on:Salvatore Golemi;Salvatore GolemiDepartment of Radiology, University of Brescia, Brescia, ItalySearch for other works by this author on:Davide FarinaDavide FarinaDepartment of Radiology, University of Brescia, Brescia, ItalySearch for other works by this author on:
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46 - 55: Transnasal Endoscopic Surgery: Surgical Techniques and ComplicationsByPaolo Battaglia;Paolo BattagliaDivision of Otorhinolaryngology – Head and Neck Surgery, Department of Biotechnology and Life Sciences, University of Insubria, Varese, ItalySearch for other works by this author on:Alessia Lambertoni;Alessia LambertoniDivision of Otorhinolaryngology – Head and Neck Surgery, Department of Biotechnology and Life Sciences, University of Insubria, Varese, ItalySearch for other works by this author on:Paolo CastelnuovoPaolo CastelnuovoDivision of Otorhinolaryngology – Head and Neck Surgery, Department of Biotechnology and Life Sciences, University of Insubria, Varese, ItalySearch for other works by this author on:
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56 - 67: Anterior Skull Base Surgery in the 21st Century: The Role of Open ApproachesBySara Abu-Ghanem;Sara Abu-GhanemDepartment of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelSearch for other works by this author on:Shahaf Shilo;Shahaf ShiloDepartment of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelSearch for other works by this author on:Moshe Yehuda;Moshe YehudaDepartment of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelSearch for other works by this author on:Avraham Abergel;Avraham AbergelDepartment of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelSearch for other works by this author on:Ahmad Safadi;Ahmad SafadiDepartment of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelSearch for other works by this author on:Dan M. FlissDan M. FlissDepartment of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelSearch for other works by this author on:
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68 - 77: Update of Radiation Techniques Using Photons for Anterior Skull Base TumorsByCorey C. Foster;Corey C. FosteraDepartment of Radiation and Cellular Oncology, University of Chicago Medicine, Chicago, Illinois, USASearch for other works by this author on:Joseph K. Kim;Joseph K. KimbState University of New York Downstate Medical Center, Brooklyn, New York, USASearch for other works by this author on:James M. Melotek;James M. MelotekcSaint Lucie Radiation Oncology, Port St. Lucie, Florida, USASearch for other works by this author on:Nancy Y. LeeNancy Y. LeedDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USASearch for other works by this author on:
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78 - 86: The Evolving Role of Systemic Therapy in the Primary Treatment of Sinonasal CancerByLisa Licitra;Lisa LicitraaHead and Neck Cancer Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalycMedical Oncology Department, University of Milan, Milan, ItalySearch for other works by this author on:Carlo Resteghini;Carlo ResteghiniaHead and Neck Cancer Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalySearch for other works by this author on:Paolo BossiPaolo BossibUnit of Oncology, University of Brescia, Brescia, ItalySearch for other works by this author on:
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87 - 105: Particle Therapy: Protons and Heavy IonsByAlexandra D. JensenAlexandra D. JensenDepartment of Radiation Oncology, University Hospitals Giessen and Marburg (UKGM), Marburg, GermanySearch for other works by this author on:
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106 - 113: Benign Tumors of the Anterior Cranial BaseByCarl H. Snyderman;Carl H. SnydermanCenter for Cranial Base Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USASearch for other works by this author on:Philippe LavignePhilippe LavigneCenter for Cranial Base Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USASearch for other works by this author on:
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114 - 123: Endoscopic Endonasal Approaches for Anterior Skull Base MeningiomasByAlexandre B. Todeschini;Alexandre B. TodeschiniaDepartment of Neurological Surgery, Wexner Medical Center, The Ohio State University College of Medicine, Columbus, Ohio, USASearch for other works by this author on:André Beer-Furlan;André Beer-FurlanbDepartment of Neurological Surgery, Rush University Medical Center, Chicago, Illinois, USASearch for other works by this author on:Brad Otto;Brad OttoaDepartment of Neurological Surgery, Wexner Medical Center, The Ohio State University College of Medicine, Columbus, Ohio, USAcDepartment of Otolaryngology – Head and Neck Surgery, Wexner Medical Center, The Ohio State University College of Medicine, Columbus, Ohio, USASearch for other works by this author on:Daniel M. Prevedello;Daniel M. PrevedelloaDepartment of Neurological Surgery, Wexner Medical Center, The Ohio State University College of Medicine, Columbus, Ohio, USAcDepartment of Otolaryngology – Head and Neck Surgery, Wexner Medical Center, The Ohio State University College of Medicine, Columbus, Ohio, USASearch for other works by this author on:Ricardo L. CarrauRicardo L. CarrauaDepartment of Neurological Surgery, Wexner Medical Center, The Ohio State University College of Medicine, Columbus, Ohio, USAcDepartment of Otolaryngology – Head and Neck Surgery, Wexner Medical Center, The Ohio State University College of Medicine, Columbus, Ohio, USASearch for other works by this author on:
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124 - 136: Squamous Cell Carcinoma and Its VariantsByNavin Mani;Navin ManiDepartment of Head and Neck Surgical Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USASearch for other works by this author on:Jatin P. ShahJatin P. ShahDepartment of Head and Neck Surgical Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USASearch for other works by this author on:
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137 - 153: A Comprehensive Update on Intestinal- and Non-Intestinal-Type AdenocarcinomasByVincent Vander Poorten;Vincent Vander PoortenaOtorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, BelgiumbSection Head of Head and Neck Oncology, Department of Oncology, KU Leuven, Leuven, BelgiumSearch for other works by this author on:Mark JorissenMark JorissenaOtorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, BelgiumcDepartment of Neurosciences, KU Leuven, Leuven, BelgiumSearch for other works by this author on:
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154 - 167: Olfactory NeuroblastomaByMathieu Veyrat;Mathieu VeyrataENT Department – Skull Base Center, Hôpital Lariboisière, Paris, FranceSearch for other works by this author on:Benjamin Vérillaud;Benjamin VérillaudaENT Department – Skull Base Center, Hôpital Lariboisière, Paris, FranceSearch for other works by this author on:Domitille Fiaux-Camous;Domitille Fiaux-CamousaENT Department – Skull Base Center, Hôpital Lariboisière, Paris, FranceSearch for other works by this author on:Sébastien Froelich;Sébastien FroelichbDepartment of Neurosurgery, Hôpital Lariboisière, Paris, FranceSearch for other works by this author on:Damien Bresson;Damien BressonbDepartment of Neurosurgery, Hôpital Lariboisière, Paris, FranceSearch for other works by this author on:Piero Nicolai;Piero NicolaicUnit of Otorhinolaryngology – Head and Neck Surgery, Department of Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, ItalySearch for other works by this author on:Philippe HermanPhilippe HermanaENT Department – Skull Base Center, Hôpital Lariboisière, Paris, FranceSearch for other works by this author on:
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168 - 184: Neuroendocrine Carcinoma and Sinonasal Undifferentiated CarcinomaByAhmed S. Abdelmeguid;Ahmed S. AbdelmeguidaDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USAbDepartment of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Mansoura University, Mansoura, EgyptSearch for other works by this author on:Diana Bell;Diana BellaDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USAcDepartment of Pathology, Division of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USASearch for other works by this author on:Ehab Y. HannaEhab Y. HannaaDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USASearch for other works by this author on:
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185 - 196: Sinonasal Malignant MelanomaByValerie J. LundValerie J. LundProfessor Emeritus in Rhinology, UCL, London UK & Honorary Consultant Rhinologist and Anterior Skull Base Surgeon, Royal National Throat, Nose and Ear Hospital, UCLH, London, United KingdomSearch for other works by this author on:
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197 - 209: Adenoid Cystic CarcinomaByPaolo Castelnuovo;Paolo CastelnuovoUnit of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Ospedale di Circolo e Fondazione Macchi, Varese, ItalySearch for other works by this author on:Mario Turri-ZanoniMario Turri-ZanoniUnit of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Ospedale di Circolo e Fondazione Macchi, Varese, ItalySearch for other works by this author on:
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210 - 217: Other Rare Sinonasal Malignant Tumours Involving the Anterior Skull BaseByRahul Naga;Rahul NagaDepartment of Head and Neck Surgical Oncology, Tata Memorial Centre, Dr. Ernest Borges Marg, Mumbai, IndiaSearch for other works by this author on:Prathamesh S. PaiPrathamesh S. PaiDepartment of Head and Neck Surgical Oncology, Tata Memorial Centre, Dr. Ernest Borges Marg, Mumbai, IndiaSearch for other works by this author on:
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218 - 230: Posttreatment Imaging SurveillanceByDavide Farina;Davide FarinaaDepartment of Radiology, University of Brescia, Brescia, ItalySearch for other works by this author on:Ivan Zorza;Ivan ZorzaaDepartment of Radiology, University of Brescia, Brescia, ItalySearch for other works by this author on:Salvatore Golemi;Salvatore GolemiaDepartment of Radiology, University of Brescia, Brescia, ItalySearch for other works by this author on:Davide Lombardi;Davide LombardibDepartment of Otolaryngology, University of Brescia, Brescia, ItalySearch for other works by this author on:Andrea Borghesi;Andrea BorghesiaDepartment of Radiology, University of Brescia, Brescia, ItalySearch for other works by this author on:Roberto Maroldi;Roberto MaroldiaDepartment of Radiology, University of Brescia, Brescia, ItalySearch for other works by this author on:Marco RavanelliMarco RavanelliaDepartment of Radiology, University of Brescia, Brescia, ItalySearch for other works by this author on:
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231 - 245: Treatment Options for Recurrent Anterior Skull Base TumorsByEster Orlandi;Ester OrlandiaRadiotherapy 1–2 Unit, Fondazione IRCCS IstitutoTumori, Milan, ItalySearch for other works by this author on:Nicola Alessandro Iacovelli;Nicola Alessandro IacovellibRadiotherapy 2 Unit, Fondazione IRCCS IstitutoTumori, Milan, ItalySearch for other works by this author on:Rossana Ingargiola;Rossana IngargiolabRadiotherapy 2 Unit, Fondazione IRCCS IstitutoTumori, Milan, ItalySearch for other works by this author on:Carlo Resteghini;Carlo ResteghinicHead and Neck Medical Oncology Unit, Fondazione IRCCS IstitutoTumori, Milan, ItalySearch for other works by this author on:Paolo Bossi;Paolo BossidUnit of Medical Oncology, University of Brescia, Brescia, ItalySearch for other works by this author on:Lisa Licitra;Lisa LicitraeHead and Neck Medical Oncology Unit, Fondazione IRCCS IstitutoTumori, Milan, ItalyfUniversity of Milan, Milan, ItalySearch for other works by this author on:Marco Ferrari;Marco FerrarigUnit of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Brescia, ItalyhSection of Otorhinolaryngology – Head and Neck Surgery, Department of Neurosciences, University of Padua, Padua, ItalySearch for other works by this author on:Piero NicolaiPiero NicolaihSection of Otorhinolaryngology – Head and Neck Surgery, Department of Neurosciences, University of Padua, Padua, ItalySearch for other works by this author on:
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246 - 250: Future Perspectives in the Management of Tumors of the Anterior Skull BaseByPiero Nicolai;Piero NicolaiaUnit of Otorhinolaryngology – Head and Neck Surgery, University of Brescia, Brescia, ItalySearch for other works by this author on:Patrick J. Bradley;Patrick J. BradleybDepartment of Otorhinolaryngology – Head and Neck Surgery, Nottingham University Hospitals, Queens Medical Centre Campus, Nottingham, United KingdomSearch for other works by this author on:Paolo Bossi;Paolo BossicUnit of Oncology, University of Brescia, Brescia, ItalySearch for other works by this author on:Marco FerrariMarco FerrariaUnit of Otorhinolaryngology – Head and Neck Surgery, University of Brescia, Brescia, ItalySearch for other works by this author on: