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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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Visceral siderosis induced in rabbits by means of repeated transfusions of erythrocytes is directly proportional to the amount of hemoglobin iron introducediit is particularly early and evident in the liver. Special experimental conditions (splenectomy) allow the importance of concomitant factors to be established, in the determination and evolution of hepatic damage.Some observations are reported on the tissular mechanism involved in the assumption, metabolism, endocellular fixation and conveyance processes of iron of erythrocyte origin.

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Subject: International Society of Blood Transfusion7th Congress, Rome, September 1958: Proceedings > 677a - 677a: Observations Regarding the Histiogenesis and Evolution of Siderosis Induced by Repeated Blood Transfusions

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