Skip to Main Content
Skip Nav Destination
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Our vast experience of 50,000 transfusions performed in two Buenos Aires Hospitals (The Italian Hospital and the Institute of Oncology) enables us to draw the following conclusions:The best treatment of transfusion reactions and their prevention is only obtained by good organization of the transfusion service. Classification of the donor's and receiver's blood according to the ABO and RH system must always be performed both with test serum and test blood cells. All Rh-negative bloods must be examined for Du and for probable immune antibodies.Complete crossmatching must be done before each transfusion, not forgetting to reclassify the contents of the bottle. The most frequent cause of hemolytic reactions at present is errors in annotation, and for this reason we prefer to use bracelets of plastic material containing the patient's name and surname, room and bed number, and Rh group.Prevention of pyrogen reactions depends on thorough washing and sterilization of the material to be used. As in our country, for economic reasons, we resterilize nearly all the material, including the plastic transfusion fittings, we have designed a special device to introduce them into the autoclave so as to avoid breakages, etc.In case of reaction, a panel investigation is performed, using known antigens, and in this way we found over 210 incompatible crossmatchings, anti-K-sensitive, anti-Fya, anti-S besides anti-Rh sensitization. Excluding incompatibility due to erythrocyte antigen-antibody, the leukocyte antibodies are then tested, and if a positive result is obtained, leukocyte-free washed red cells are transfused. We always perform isogroup transfusions and we also prefer to use isogroup plasma and, for Rh-negative patients, we take special care in investigating hot antibodies which might simulate Rh antigen. Working on these lines we have been able to decrease the percentage of pyrogen reactions from 7.70% in 1951 to 1.31 % in 1957. (We believe that many reactions thought to be caused by pyrogens, in 1951, were not really so.) At the same time, we have always tried to increase the number of our panel donors who, in certain cases, may act as special donors. In 370 determinations we found the following frequencies:Kell positive: 11 % ; Celiano positive: 96 % ; Duffya, positive: 68 % ; M positive: 25 %; N positive: 25 %; MN positive: 50 %; S positive: 45 %.

Send Email

Recipient(s) will receive an email with a link to 'International Society of Blood Transfusion7th Congress, Rome, September 1958: Proceedings > 676a - 677: Prevention of Complications in Blood Transfusion' and will not need an account to access the content.

Subject: International Society of Blood Transfusion7th Congress, Rome, September 1958: Proceedings > 676a - 677: Prevention of Complications in Blood Transfusion

(Optional message may have a maximum of 1000 characters.)

×
Close Modal

or Create an Account

Close Modal
Close Modal