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Wigand, Möller and we ourselves (Stacker and Bohnel) noted that in two-thirds of our cases, blood transfusions free from disturbances act as a slight stress on the receiver, whilst in pyrogenic transfusions this stress is greatly increased. It may also be influenced by anti-histamines. The study of patients, under this aspect, with normal coagulation conditions with respect to the behaviour of coagulation factors after transfusion therefore appeared to be of interest. For this purpose, certain quantities of preserved blood were divided into two parts ithe first was trans¬fused without anti-histamines and the second was given the day after, following intramuscular injection of Synistamin (Chlorotrimeton). Each time, the protrombin, factor V, factor VII, thrombin inhibitor, and the recalcification time were determined before the transfusion, immediately after and then at half hourly intervals for a further two hours, and the differentiated leukocyte curves were drawn up. The same examinations were repeated in blank, after injecting a pyrogenic substance (Pyrexal). The results and the various deductions reached are reported in the article.

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Subject: International Society of Blood Transfusion7th Congress, Rome, September 1958: Proceedings > 474a - 474a: Concerning the Action of Anti-Histamines on Coagulation Factors after Blood Transfusions

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