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Fresh, frozen or lyophilized platelet concentrates (from 4000 pints of human blood) were administdere to 278 thrombocytopenic patients. Hemostasis occurred in 60 per cent. In 85 per cent vascular fragility was reduced. Thromboembolic phenomena were not encountered. Hypersensitization due to platelets from incompatible blood was not observed. In 30 patients whose bone marrow improved eventually, the platelet level returned to normal. Large amounts of platelets were usually required to induce hemostasis. The effects of fresh platelets last longer than those of preserved platelets which do not circulate. While the use of fresh platelets is preferable because of the smaller doses required and the longer lasting effects, the preserved material permits salvage of platelets and thus makes possible the use of larger quantities when fresh material is not available.

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Subject: International Society of Blood Transfusion7th Congress, Rome, September 1958: Proceedings > 1012a - 1012a: Transfusion of Platelet Concentrates to Thrombocytopenic Patients

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