288a - 288a: Mechanism of the Decreased Capillary Resistance Following Plasma Expander Infusion Free
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Published:1958
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Discontinued Book Series: Current Studies in Hematology and Blood TransfusionSubject Area: Hematology
V. G. Behrmann, 1958. "Mechanism of the Decreased Capillary Resistance Following Plasma Expander Infusion", International Society of Blood Transfusion: 6th Congress in Conjunction with the 9th Annual Meeting of the American Association of Blood Banks, Boston, Mass., September 1956: Proceedings, L.P. Holländer
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Abstract
A decreased capillary resistance, associated with hypoprothrombinemia, hypo-fibrinogenemia and thrombocytopenia, has been observed after infusions of dextran, PVP, pectin esters and methyl cellulose; whereas normal findings were seen after isotonic saline or gelatin injections. Studies on intact dogs, splenectomized dogs and splenectomized animals with RES block after massive infusions (40 cc/kg) are reported. Animals given daily infusions (10-22 cc/kg) for 21 days show the cumulative effects of these plasma expanders.Evidence is presented which emphasizes that reticuloendothelial system deposition, depression in platelet formation, and liver retention are important factors related to the altered capillary permeability.