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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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A decreased capillary resistance, associated with hypoprothrombinemia, hypo-fibrinogenemia and thrombocytopenia, has been observed after infusions of dextran, PVP, pectin esters and methyl cellulose; whereas normal findings were seen after isotonic saline or gelatin injections. Studies on intact dogs, splenectomized dogs and splenectomized animals with RES block after massive infusions (40 cc/kg) are reported. Animals given daily infusions (10-22 cc/kg) for 21 days show the cumulative effects of these plasma expanders.Evidence is presented which emphasizes that reticuloendothelial system deposition, depression in platelet formation, and liver retention are important factors related to the altered capillary permeability.

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Subject: International Society of Blood Transfusion6th Congress in Conjunction with the 9th Annual Meeting of the American Association of Blood Banks, Boston, Mass., September 1956: Proceedings > 288a - 288a: Mechanism of the Decreased Capillary Resistance Following Plasma Expander Infusion

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