Adult Stem Cells in Aging, Diseases and Cancer
The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.
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Table of Contents
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1 - 2: IntroductionByKarl Lenhard RudolphKarl Lenhard RudolphLeibniz Institute for Age Research, Fritz Lipmann Institute, Jena, GermanySearch for other works by this author on:
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18 - 24: Stem Cells in Adult IntestineByJuan Feng;Juan FengLeibniz Institute for Age Research, Fritz Lipmann Institute, Jena, GermanySearch for other works by this author on:Tobias SperkaTobias SperkaLeibniz Institute for Age Research, Fritz Lipmann Institute, Jena, GermanySearch for other works by this author on:
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25 - 39: Molecular Mechanisms of Muscle Stem Cell AgingBySimon Schwörer;Simon SchwörerLeibniz Institute for Age Research, Fritz Lipmann Institute, Jena, GermanySearch for other works by this author on:Stefan TümpelStefan TümpelLeibniz Institute for Age Research, Fritz Lipmann Institute, Jena, GermanySearch for other works by this author on:
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40 - 59: Mechanism of Functional Alterations in Hematopoietic Stem Cell AgingByYohei MoritaYohei MoritaLeibniz Institute for Age Research, Fritz Lipmann Institute, Jena, GermanySearch for other works by this author on:
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60 - 65: The Microenvironment, Aging and DiseaseByHartmut GeigerHartmut GeigerInstitute of Molecular Medicine, Aging and Stem Cells, University of Ulm, Ulm, GermanySearch for other works by this author on:
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66 - 68: Sestrins in Aging and MetabolismByDuozhuang Tang;Duozhuang TangLeibniz Institute for Age Research, Fritz Lipmann Institute, Jena, GermanySearch for other works by this author on:Si TaoSi TaoLeibniz Institute for Age Research, Fritz Lipmann Institute, Jena, GermanySearch for other works by this author on:
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69 - 73: Telomeres and Stem Cell AgingByDaniel A. FelixDaniel A. FelixLeibniz Institute for Age Research, Fritz Lipmann Institute, Jena, GermanySearch for other works by this author on:
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74 - 82: DNA Damage and Checkpoint Responses in Adult Stem CellsByVasily Romanov;Vasily RomanovaLeibniz Institute for Age Research - Fritz Lipmann Institute, Jena, Germany;Search for other works by this author on:Aruna Shukla;Aruna ShuklabInstitute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, ChinaSearch for other works by this author on:Zhenyu JuZhenyu JubInstitute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, ChinaSearch for other works by this author on: