Frailty in Aging: Biological, Clinical and Social ImplicationsAvailable to Purchase
Frailty represents an important challenge for aging populations. As a concept it is full of 'known unknowns' such as which mechanisms lead to frailty and how it is best managed. In order to examine these circumstances, the new science of understanding and managing frailty requires an appropriate framing of the problem. This publication investigates the biology and management of frailty and its social aspects. It considers these and related questions: How can we recognize frailty? How does an understanding of frailty increase our comprehension of the aging process? What are its implications for health care systems, including primary care, hospitals and rehabilitation? How will a growing number of frail older adults affect society more generally? The book focuses on frailty as a state of vulnerability, which is related to aging, but which can occur across the life course, and aims to improve the life of frail people and those around them. The book is highly recommended to researchers in aging, health science researchers, health care professionals and anyone interested in the understanding of the aging process.
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Frailty: Scaling from Cellular Deficit Accumulation?ByKenneth Rockwood;Kenneth RockwoodDivisions of <sup>a</sup>Geriatric Medicine and <sup>b</sup>Neurology, Department of Medicine, and Departments of <sup>c</sup>Medicine and <sup>d</sup>Pharmacology, Dalhousie University, Halifax, N.S., Canada; Departments of <sup>e</sup>Geriatric Medicine and <sup>f</sup>Physiology, and Institutes of <sup>g</sup>Brain, Behaviour and Neurosciences, and <sup>h</sup>Cardiovascular Sciences, University of Manchester, Manchester, UKSearch for other works by this author on:Arnold Mitnitski;Arnold MitnitskiDivisions of <sup>a</sup>Geriatric Medicine and <sup>b</sup>Neurology, Department of Medicine, and Departments of <sup>c</sup>Medicine and <sup>d</sup>Pharmacology, Dalhousie University, Halifax, N.S., Canada; Departments of <sup>e</sup>Geriatric Medicine and <sup>f</sup>Physiology, and Institutes of <sup>g</sup>Brain, Behaviour and Neurosciences, and <sup>h</sup>Cardiovascular Sciences, University of Manchester, Manchester, UKSearch for other works by this author on:Susan E. HowlettSusan E. HowlettDivisions of <sup>a</sup>Geriatric Medicine and <sup>b</sup>Neurology, Department of Medicine, and Departments of <sup>c</sup>Medicine and <sup>d</sup>Pharmacology, Dalhousie University, Halifax, N.S., Canada; Departments of <sup>e</sup>Geriatric Medicine and <sup>f</sup>Physiology, and Institutes of <sup>g</sup>Brain, Behaviour and Neurosciences, and <sup>h</sup>Cardiovascular Sciences, University of Manchester, Manchester, UKSearch for other works by this author on:
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Assessment of Frailty in Animal ModelsBySusan E. HowlettSusan E. Howlett<sup>a</sup>Department of Pharmacology and <sup>b</sup>Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, N.S., Canada; <sup>c</sup>Department of Physiology, Institute of Cardiovascular Sciences, University of Manchester, Manchester, UKSearch for other works by this author on:
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Frailty, Inflammation and ImmunosenescenceByTamas Fulop;Tamas Fulop<sup>a</sup>Geriatrics Division, Department of Medicine and <sup>b</sup>Department of Family Medicine and <sup>c</sup>Research Center on Aging, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Que., and <sup>d</sup>Advanced Medical Research Institute of Canada, Sudbury, Ont., and <sup>e</sup>Division of Geriatric Medicine, Department of Medicine and <sup>f</sup>McGill Nutrition and Food Science Centre and <sup>g</sup>Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Que., Canada; <sup>h</sup>Center for Medical Research, University of Tübingen, Tübingen, Germany; <sup>i</sup>Singapore Immunology Network (SIgN), Biopolis, Agency for Science Technology and Research (A*STAR), Singapore, Singapore; <sup>j</sup>Department of Pathophysiology, Medical University of Gdansk, Gdansk, PolandSearch for other works by this author on:Janet McElhaney;Janet McElhaney<sup>a</sup>Geriatrics Division, Department of Medicine and <sup>b</sup>Department of Family Medicine and <sup>c</sup>Research Center on Aging, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Que., and <sup>d</sup>Advanced Medical Research Institute of Canada, Sudbury, Ont., and <sup>e</sup>Division of Geriatric Medicine, Department of Medicine and <sup>f</sup>McGill Nutrition and Food Science Centre and <sup>g</sup>Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Que., Canada; <sup>h</sup>Center for Medical Research, University of Tübingen, Tübingen, Germany; <sup>i</sup>Singapore Immunology Network (SIgN), Biopolis, Agency for Science Technology and Research (A*STAR), Singapore, Singapore; <sup>j</sup>Department of Pathophysiology, Medical University of Gdansk, Gdansk, PolandSearch for other works by this author on:Graham Pawelec;Graham Pawelec<sup>a</sup>Geriatrics Division, Department of Medicine and <sup>b</sup>Department of Family Medicine and <sup>c</sup>Research Center on Aging, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Que., and <sup>d</sup>Advanced Medical Research Institute of Canada, Sudbury, Ont., and <sup>e</sup>Division of Geriatric Medicine, Department of Medicine and <sup>f</sup>McGill Nutrition and Food Science Centre and <sup>g</sup>Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Que., Canada; <sup>h</sup>Center for Medical Research, University of Tübingen, Tübingen, Germany; <sup>i</sup>Singapore Immunology Network (SIgN), Biopolis, Agency for Science Technology and Research (A*STAR), Singapore, Singapore; <sup>j</sup>Department of Pathophysiology, Medical University of Gdansk, Gdansk, PolandSearch for other works by this author on:Alan A. Cohen;Alan A. Cohen<sup>a</sup>Geriatrics Division, Department of Medicine and <sup>b</sup>Department of Family Medicine and <sup>c</sup>Research Center on Aging, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Que., and <sup>d</sup>Advanced Medical Research Institute of Canada, Sudbury, Ont., and <sup>e</sup>Division of Geriatric Medicine, Department of Medicine and <sup>f</sup>McGill Nutrition and Food Science Centre and <sup>g</sup>Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Que., Canada; <sup>h</sup>Center for Medical Research, University of Tübingen, Tübingen, Germany; <sup>i</sup>Singapore Immunology Network (SIgN), Biopolis, Agency for Science Technology and Research (A*STAR), Singapore, Singapore; <sup>j</sup>Department of Pathophysiology, Medical University of Gdansk, Gdansk, PolandSearch for other works by this author on:José A. Morais;José A. Morais<sup>a</sup>Geriatrics Division, Department of Medicine and <sup>b</sup>Department of Family Medicine and <sup>c</sup>Research Center on Aging, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Que., and <sup>d</sup>Advanced Medical Research Institute of Canada, Sudbury, Ont., and <sup>e</sup>Division of Geriatric Medicine, Department of Medicine and <sup>f</sup>McGill Nutrition and Food Science Centre and <sup>g</sup>Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Que., Canada; <sup>h</sup>Center for Medical Research, University of Tübingen, Tübingen, Germany; <sup>i</sup>Singapore Immunology Network (SIgN), Biopolis, Agency for Science Technology and Research (A*STAR), Singapore, Singapore; <sup>j</sup>Department of Pathophysiology, Medical University of Gdansk, Gdansk, PolandSearch for other works by this author on:Gilles Dupuis;Gilles Dupuis<sup>a</sup>Geriatrics Division, Department of Medicine and <sup>b</sup>Department of Family Medicine and <sup>c</sup>Research Center on Aging, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Que., and <sup>d</sup>Advanced Medical Research Institute of Canada, Sudbury, Ont., and <sup>e</sup>Division of Geriatric Medicine, Department of Medicine and <sup>f</sup>McGill Nutrition and Food Science Centre and <sup>g</sup>Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Que., Canada; <sup>h</sup>Center for Medical Research, University of Tübingen, Tübingen, Germany; <sup>i</sup>Singapore Immunology Network (SIgN), Biopolis, Agency for Science Technology and Research (A*STAR), Singapore, Singapore; <sup>j</sup>Department of Pathophysiology, Medical University of Gdansk, Gdansk, PolandSearch for other works by this author on:Sarra Baehl;Sarra Baehl<sup>a</sup>Geriatrics Division, Department of Medicine and <sup>b</sup>Department of Family Medicine and <sup>c</sup>Research Center on Aging, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Que., and <sup>d</sup>Advanced Medical Research Institute of Canada, Sudbury, Ont., and <sup>e</sup>Division of Geriatric Medicine, Department of Medicine and <sup>f</sup>McGill Nutrition and Food Science Centre and <sup>g</sup>Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Que., Canada; <sup>h</sup>Center for Medical Research, University of Tübingen, Tübingen, Germany; <sup>i</sup>Singapore Immunology Network (SIgN), Biopolis, Agency for Science Technology and Research (A*STAR), Singapore, Singapore; <sup>j</sup>Department of Pathophysiology, Medical University of Gdansk, Gdansk, PolandSearch for other works by this author on:Xavier Camous;Xavier Camous<sup>a</sup>Geriatrics Division, Department of Medicine and <sup>b</sup>Department of Family Medicine and <sup>c</sup>Research Center on Aging, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Que., and <sup>d</sup>Advanced Medical Research Institute of Canada, Sudbury, Ont., and <sup>e</sup>Division of Geriatric Medicine, Department of Medicine and <sup>f</sup>McGill Nutrition and Food Science Centre and <sup>g</sup>Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Que., Canada; <sup>h</sup>Center for Medical Research, University of Tübingen, Tübingen, Germany; <sup>i</sup>Singapore Immunology Network (SIgN), Biopolis, Agency for Science Technology and Research (A*STAR), Singapore, Singapore; <sup>j</sup>Department of Pathophysiology, Medical University of Gdansk, Gdansk, PolandSearch for other works by this author on:Jacek M. Witkowski;Jacek M. Witkowski<sup>a</sup>Geriatrics Division, Department of Medicine and <sup>b</sup>Department of Family Medicine and <sup>c</sup>Research Center on Aging, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Que., and <sup>d</sup>Advanced Medical Research Institute of Canada, Sudbury, Ont., and <sup>e</sup>Division of Geriatric Medicine, Department of Medicine and <sup>f</sup>McGill Nutrition and Food Science Centre and <sup>g</sup>Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Que., Canada; <sup>h</sup>Center for Medical Research, University of Tübingen, Tübingen, Germany; <sup>i</sup>Singapore Immunology Network (SIgN), Biopolis, Agency for Science Technology and Research (A*STAR), Singapore, Singapore; <sup>j</sup>Department of Pathophysiology, Medical University of Gdansk, Gdansk, PolandSearch for other works by this author on:Anis LarbiAnis Larbi<sup>a</sup>Geriatrics Division, Department of Medicine and <sup>b</sup>Department of Family Medicine and <sup>c</sup>Research Center on Aging, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Que., and <sup>d</sup>Advanced Medical Research Institute of Canada, Sudbury, Ont., and <sup>e</sup>Division of Geriatric Medicine, Department of Medicine and <sup>f</sup>McGill Nutrition and Food Science Centre and <sup>g</sup>Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Que., Canada; <sup>h</sup>Center for Medical Research, University of Tübingen, Tübingen, Germany; <sup>i</sup>Singapore Immunology Network (SIgN), Biopolis, Agency for Science Technology and Research (A*STAR), Singapore, Singapore; <sup>j</sup>Department of Pathophysiology, Medical University of Gdansk, Gdansk, PolandSearch for other works by this author on:
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Frailty and the MicrobiomeByConor J. Meehan;Conor J. Meehan<sup>a</sup>Faculty of Computer Science, <sup>b</sup>Department of Biochemistry and Molecular Biology and <sup>c</sup>Department of Pharmacology, Dalhousie University, Halifax, N.S., CanadaSearch for other works by this author on:Morgan G.I. Langille;Morgan G.I. Langille<sup>a</sup>Faculty of Computer Science, <sup>b</sup>Department of Biochemistry and Molecular Biology and <sup>c</sup>Department of Pharmacology, Dalhousie University, Halifax, N.S., CanadaSearch for other works by this author on:Robert G. BeikoRobert G. Beiko<sup>a</sup>Faculty of Computer Science, <sup>b</sup>Department of Biochemistry and Molecular Biology and <sup>c</sup>Department of Pharmacology, Dalhousie University, Halifax, N.S., CanadaSearch for other works by this author on:
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Operationalizing Frailty Using the Frailty Phenotype and Deficit Accumulation ApproachesByOlga Theou;Olga Theou<sup>a</sup>Geriatric Medicine, Faculty of Medicine, Dalhousie University, Halifax, N.S., Canada; <sup>b</sup>Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University, Baltimore, Md., USASearch for other works by this author on:Jeremy Walston;Jeremy Walston<sup>a</sup>Geriatric Medicine, Faculty of Medicine, Dalhousie University, Halifax, N.S., Canada; <sup>b</sup>Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University, Baltimore, Md., USASearch for other works by this author on:Kenneth RockwoodKenneth Rockwood<sup>a</sup>Geriatric Medicine, Faculty of Medicine, Dalhousie University, Halifax, N.S., Canada; <sup>b</sup>Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University, Baltimore, Md., USASearch for other works by this author on:
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Frailty and MobilityByEamonn Eeles;Eamonn Eeles<sup>a</sup>Internal Medicine Services, The Prince Charles Hospital and <sup>b</sup>The Prince Charles Hospital, The University of Queensland, Chermside, and <sup>c</sup>School of Physiotherapy, Faculty of Health Sciences, Australian Catholic University, Banyo, Qld., AustraliaSearch for other works by this author on:Nancy Low ChoyNancy Low Choy<sup>a</sup>Internal Medicine Services, The Prince Charles Hospital and <sup>b</sup>The Prince Charles Hospital, The University of Queensland, Chermside, and <sup>c</sup>School of Physiotherapy, Faculty of Health Sciences, Australian Catholic University, Banyo, Qld., AustraliaSearch for other works by this author on:
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Frailty and Interprofessional CollaborationByMarion C.E. Briggs;Marion C.E. Briggs<sup>a</sup>Northern Ontario School of Medicine and <sup>b</sup>Health Sciences North and <sup>c</sup>Advanced Medical Research Institute of Canada, Sudbury, and <sup>d</sup>AMS Phoenix Project, Toronto, Ont., CanadaSearch for other works by this author on:Janet E. McElhaneyJanet E. McElhaney<sup>a</sup>Northern Ontario School of Medicine and <sup>b</sup>Health Sciences North and <sup>c</sup>Advanced Medical Research Institute of Canada, Sudbury, and <sup>d</sup>AMS Phoenix Project, Toronto, Ont., CanadaSearch for other works by this author on:
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Frailty and RehabilitationByIan D. Cameron;Ian D. Cameron<sup>a</sup>John Walsh Centre for Rehabilitation Research, Sydney Medical School Northern, The University of Sydney, Kolling Institute, Royal North Shore Hospital, St Leonards, N.S.W., and <sup>b</sup>Division of Rehabilitation and Aged Care, Hornsby Ku-ring-gai Health Service, Hornsby, N.S.W., AustraliaSearch for other works by this author on:Susan E. KurrleSusan E. Kurrle<sup>a</sup>John Walsh Centre for Rehabilitation Research, Sydney Medical School Northern, The University of Sydney, Kolling Institute, Royal North Shore Hospital, St Leonards, N.S.W., and <sup>b</sup>Division of Rehabilitation and Aged Care, Hornsby Ku-ring-gai Health Service, Hornsby, N.S.W., AustraliaSearch for other works by this author on:
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Frailty's Place in Ethics and Law: Some Thoughts on Equality and Autonomy and on Limits and Possibilities for Aging CitizensByMary McNally;Mary McNally<sup>a</sup>Faculties of Dentistry and Medicine and <sup>b</sup>Schulich School of Law and School of Health Administration, Dalhousie University, Halifax, N.S., CanadaSearch for other works by this author on:William LaheyWilliam Lahey<sup>a</sup>Faculties of Dentistry and Medicine and <sup>b</sup>Schulich School of Law and School of Health Administration, Dalhousie University, Halifax, N.S., CanadaSearch for other works by this author on: