Microbial PathogenomicsAvailable to Purchase
'Microbial Pathogenomics' contains a unique collection of reviews demonstrating how genomics has revolutionized our understanding of virulence, host-adaptation strategies and the evolution of bacterial pathogens. Current technologies - computational tools and functional approaches to genome analysis - are carefully documented and clearly illustrated. These include visualization tools for genome comparison, databases, in silico metabolic reconstructions and function prediction as well as interactomics for the study of protein-protein interactions. The concepts of pan-genomics and reverse vaccinology are introduced as strategies when addressing the challenge presented by bacterial diversity in the prevention and treatment of infectious diseases. The authors explore individual bacterial pathogens and discuss the mechanisms that have contributed to their evolutionary success. Special cases of host adaptation, for example, are illustrated by Helicobacter pylori and 'Mycobacterium tuberculosis' which are human-specific and highly persistent; further bacteria discussed include 'Escherichia coli, Campylobacter, Pseudomonas, Legionella, Bartonella, Burkholderia' and 'Staphylococcus'. 'Microbial Pathogenomics' provides the reader with a global view of key aspects and future trends in bacterial pathogenomics and evaluates their impact on the understanding and treatment of infectious diseases. Well illustrated and accessible to both specialists and nonspecialists, it is recommended not only for researchers in microbiology, genomics and biotechnology, but also for lecturers and teachers.
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Table of Contents
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1 - 20: Genome Comparison of Bacterial PathogensByT.M. Wassenaar;T.M. WassenaaraCenter for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark;bMolecular Microbiology and Genomics Consultants, Zotzenheim, Germany;Search for other works by this author on:J. Bohlin;J. BohlincNorwegian School of Veterinary Science, Epi-Center, Department of Food Safety and Infection Biology, and National Veterinary Institute, Section of Epidemiology, Oslo, Norway;Search for other works by this author on:T.T. Binnewies;T.T. BinnewiesaCenter for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark;dRoche Diagnostics Ltd., Rotkreuz, SwitzerlandSearch for other works by this author on:D.W. UsseryD.W. UsseryaCenter for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark;Search for other works by this author on:
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21 - 34: In silico Reconstruction of the Metabolic and Pathogenic Potential of Bacterial Genomes Using SubsystemsByL.K. McNeil;L.K. McNeilaNational Center for Supercomputing Applications, University of Illinois, Urbana, Ill., USA;Search for other works by this author on:R.K. AzizR.K. AzizbDepartment of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, EgyptSearch for other works by this author on:
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35 - 47: The Bacterial Pan-Genome and Reverse VaccinologyByH. TettelinH. TettelinInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Md., USASearch for other works by this author on:
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48 - 61: ‘Guilty by Association’ – Protein-Protein Interactions (PPIs) in Bacterial PathogensByK. Schauer;K. SchaueraMolecular Mechanisms of Intracellular Transport, UMR 144 CNRS, Institut Curie, Paris, France;Search for other works by this author on:K. StinglK. StinglbInstitut für Allgemeine Zoologie und Genetik, Westfälische Wilhelms-Universität, Münster, GermanySearch for other works by this author on:
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62 - 74: Helicobacter pylori Sequences Reflect Past Human MigrationsByY. Moodley;Y. MoodleyDepartment of Molecular Biology, Max-Plank Institute for Infection Biology, Berlin, GermanySearch for other works by this author on:B. LinzB. LinzDepartment of Molecular Biology, Max-Plank Institute for Infection Biology, Berlin, GermanySearch for other works by this author on:
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75 - 90: Helicobacter pylori Genome PlasticityByD.A. Baltrus;D.A. BaltrusaDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.,Search for other works by this author on:M.J. Blaser;M.J. BlaserbDepartment of Medicine, New York University School of Medicine, New York, N.Y,Search for other works by this author on:K. GuilleminK. GuillemincInstitute of Molecular Biology, University of Oregon, Eugene, Oreg., USASearch for other works by this author on:
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91 - 109: Genomics of Thermophilic Campylobacter SpeciesByD.J.H. Gaskin;D.J.H. GaskinInstitute of Food Research, Norwich Research Park, Norwich, UKSearch for other works by this author on:M. Reuter;M. ReuterInstitute of Food Research, Norwich Research Park, Norwich, UKSearch for other works by this author on:N. Shearer;N. ShearerInstitute of Food Research, Norwich Research Park, Norwich, UKSearch for other works by this author on:F. Mulholland;F. MulhollandInstitute of Food Research, Norwich Research Park, Norwich, UKSearch for other works by this author on:B.M. Pearson;B.M. PearsonInstitute of Food Research, Norwich Research Park, Norwich, UKSearch for other works by this author on:A.H.M. van VlietA.H.M. van VlietInstitute of Food Research, Norwich Research Park, Norwich, UKSearch for other works by this author on:
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110 - 125: Adaptation of Pathogenic E. coli to Various Niches: Genome Flexibility is the KeyByE. Brzuszkiewicz;E. BrzuszkiewiczaGöttingen Genomics Laboratory, University of Göttingen, Göttingen,bRobert-Koch-Institute, Berlin,Search for other works by this author on:G. Gottschalk;G. GottschalkaGöttingen Genomics Laboratory, University of Göttingen, Göttingen,Search for other works by this author on:E. Ron;E. RoncTel Aviv University, Department of Molecular Microbiology and Biotechnology, Ramat Aviv, IsraelSearch for other works by this author on:J. Hacker;J. HackerbRobert-Koch-Institute, Berlin,dUniversity of Würzburg, Institute for Molecular Infection Biology, Würzburg, Germany;Search for other works by this author on:U. DobrindtU. DobrindtdUniversity of Würzburg, Institute for Molecular Infection Biology, Würzburg, Germany;Search for other works by this author on:
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126 - 139: Role of Horizontal Gene Transfer in the Evolution of Pseudomonas aeruginosa VirulenceByX. Qiu;X. QiuDepartment of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Mass., USASearch for other works by this author on:B.R. Kulasekara;B.R. KulasekaraDepartment of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Mass., USASearch for other works by this author on:S. LoryS. LoryDepartment of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Mass., USASearch for other works by this author on:
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140 - 157: The Genus Burkholderia: Analysis of 56 Genomic SequencesByD.W. Ussery;D.W. UsseryaCenter for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark;Search for other works by this author on:K. Kiil;K. KiilaCenter for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark;Search for other works by this author on:K. Lagesen;K. LagesenbDepartment of Informatics, University of Oslo, Blindern, Oslo, and the Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, University of Oslo, Oslo,Search for other works by this author on:T. Sicheritz-Pontén;T. Sicheritz-PonténaCenter for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark;Search for other works by this author on:J. Bohlin;J. BohlincNorwegian School of Veterinary Science, Oslo, Norway;Search for other works by this author on:T.M. WassenaarT.M. WassenaaraCenter for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark;dMolecular Microbiology and Genomics Consultants, Zotzenheim, GermanySearch for other works by this author on:
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158 - 169: Genomics of Host-Restricted Pathogens of the Genus Bartonella
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170 - 186: Legionella pneumophila – Host Interactions: Insights Gained from Comparative Genomics and Cell BiologyByM. Lomma;M. LommaInstitut Pasteur, Unité Biologie des Bactéries Intracellulaires and CNRS URA 2171, Paris, FranceSearch for other works by this author on:Laura Gomez Valero;Laura Gomez ValeroInstitut Pasteur, Unité Biologie des Bactéries Intracellulaires and CNRS URA 2171, Paris, FranceSearch for other works by this author on:C. Rusniok;C. RusniokInstitut Pasteur, Unité Biologie des Bactéries Intracellulaires and CNRS URA 2171, Paris, FranceSearch for other works by this author on:C. BuchrieserC. BuchrieserInstitut Pasteur, Unité Biologie des Bactéries Intracellulaires and CNRS URA 2171, Paris, FranceSearch for other works by this author on:
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187 - 197: A Proteomics View of Virulence Factors of Staphylococcus aureusByS. Engelmann;S. EngelmannInstitut für Mikrobiologie, Ernst-Moritz-Arndt-Universität, Greifswald, GermanySearch for other works by this author on:M. HeckerM. HeckerInstitut für Mikrobiologie, Ernst-Moritz-Arndt-Universität, Greifswald, GermanySearch for other works by this author on:
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198 - 210: Pathogenomics of MycobacteriaByM.C. Gutierrez;M.C. GutierrezaInstitut Pasteur, Department Infection and Epidemiology, Paris,Search for other works by this author on:P. Supply;P. SupplybINSERM U629 and Institut Pasteur de Lille, Lille,Search for other works by this author on:R. BroschR. BroschcInstitut Pasteur, UP Pathogénomique Mycobactérienne Intégrée, Paris, FranceSearch for other works by this author on: