Models of Exacerbations in Asthma and COPD
This volume provides an overview of exacerbation models of asthma and chronic obstructive pulmonary disease (COPD). Within this wide field the book focuses on experimental systems that mimic pathobiological processes likely to be critical in exacerbations of these conditions.
To generate insight into the mechanisms of exacerbation of pulmonary disease and to promote the discovery of future treatments, both animal models and human experimental models are described. For this update some of the most eminent scientists within the area of pulmonology could be recruited to share their knowledge of this evolving field of human medicine. Models of Exacerbations in Asthma and COPD will be of great interest to pulmonologists, allergologists, specialists in internal medicine and critical care, as well as to microbiologists, infectiologists and pharmacologists studying the response to respiratory infections.
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Table of Contents
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1 - 11: Exacerbations of Asthma and COPD: Definitions, Clinical Manifestations and EpidemiologyByPaul M. O’ByrnePaul M. O’ByrneFirestone Institute for Respiratory Health, St. Joseph’s Hospital, Hamilton,Ont., CanadaSearch for other works by this author on:
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12 - 20: Human Rhinovirus Models in AsthmaByAnne Marie Singh;Anne Marie SinghDepartment of Medicine, University of Wisconsin Medical School,Madison, Wisc., USASearch for other works by this author on:William W. BusseWilliam W. BusseDepartment of Medicine, University of Wisconsin Medical School,Madison, Wisc., USASearch for other works by this author on:
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21 - 32: Allergen Inhalation Challenge: A Human Model of Asthma ExacerbationByGail M. Gauvreau;Gail M. GauvreauDepartment of Medicine, McMaster University, Hamilton, Ont., CanadaSearch for other works by this author on:Michelle Y. EvansMichelle Y. EvansDepartment of Medicine, McMaster University, Hamilton, Ont., CanadaSearch for other works by this author on:
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33 - 41: Cellular and Animals Models for Rhinovirus Infection in AsthmaByMaria Xatzipsalti;Maria XatzipsaltiAllergy Department, 2nd Pediatric Clinic, University of Athens, Athens, GreeceSearch for other works by this author on:Nikolaos G. PapadopoulosNikolaos G. PapadopoulosAllergy Department, 2nd Pediatric Clinic, University of Athens, Athens, GreeceSearch for other works by this author on:
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42 - 67: Modeling Responses to Respiratory House Dust Mite ExposureByElizabeth C. Cates;Elizabeth C. CatesDepartment of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ont., CanadaSearch for other works by this author on:Ramzi Fattouh;Ramzi FattouhDepartment of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ont., CanadaSearch for other works by this author on:Jill R. Johnson;Jill R. JohnsonDepartment of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ont., CanadaSearch for other works by this author on:Alba Llop-Guevara;Alba Llop-GuevaraDepartment of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ont., CanadaSearch for other works by this author on:Manel JordanaManel JordanaDepartment of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ont., CanadaSearch for other works by this author on:
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68 - 82: Respiratory Syncytial Virus-Induced Pulmonary Disease and Exacerbation of Allergic AsthmaByNicholas W. Lukacs;Nicholas W. LukacsDepartment of Pathology, University of Michigan Medical School,Ann Arbor, Mich., USASearch for other works by this author on:Joost Smit;Joost SmitDepartment of Pathology, University of Michigan Medical School,Ann Arbor, Mich., USASearch for other works by this author on:Dennis Lindell;Dennis LindellDepartment of Pathology, University of Michigan Medical School,Ann Arbor, Mich., USASearch for other works by this author on:Matthew SchallerMatthew SchallerDepartment of Pathology, University of Michigan Medical School,Ann Arbor, Mich., USASearch for other works by this author on:
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83 - 100: Lipopolysaccharide Challenge of Humans as a Model for Chronic Obstructive Lung Disease ExacerbationsBySergei A. Kharitonov;Sergei A. KharitonovaSection of Airway Disease, National Heart and Lung Institute, Imperial College London andbRoyal Brompton and Harefield NHS Trust, London, UK;Search for other works by this author on:Ulf SjöbringUlf SjöbringcDepartment of Medial Science, AstraZeneca R&D anddInstitute of Laboratory Medicine, Lund University, Lund, SwedenSearch for other works by this author on:
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101 - 112: A Human Rhinovirus Model of Chronic Obstructive Pulmonary Disease ExacerbationsByMarco Contoli;Marco ContoliaDepartment of Clinical and Experimental Medicine, Research Center on Asthma and COPD, University of Ferrara, Ferrara, Italy;b Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, London, UKSearch for other works by this author on:Gaetano Caramori;Gaetano CaramoriaDepartment of Clinical and Experimental Medicine, Research Center on Asthma and COPD, University of Ferrara, Ferrara, Italy;Search for other works by this author on:Patrick Mallia;Patrick Malliab Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, London, UKSearch for other works by this author on:Alberto Papi;Alberto PapiaDepartment of Clinical and Experimental Medicine, Research Center on Asthma and COPD, University of Ferrara, Ferrara, Italy;Search for other works by this author on:Sebastian L. JohnstonSebastian L. Johnstonb Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, London, UKSearch for other works by this author on:
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113 - 125: Animal Models of Cigarette Smoke-Induced Chronic Obstructive Lung DiseaseByAndrew Churg;Andrew ChurgDepartment of Pathology, University of British Columbia, Vancouver, B.C., CanadaSearch for other works by this author on:Joanne L. WrightJoanne L. WrightDepartment of Pathology, University of British Columbia, Vancouver, B.C., CanadaSearch for other works by this author on:
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126 - 141: Animal Models of Chronic Obstructive Pulmonary Disease ExacerbationsByGordon J. Gaschler;Gordon J. GaschleraDepartment of Pathology and Molecular Medicine, Centre for Gene Therapeutics andSearch for other works by this author on:Carla M.T. Bauer;Carla M.T. BaueraDepartment of Pathology and Molecular Medicine, Centre for Gene Therapeutics andSearch for other works by this author on:Caleb C.J. Zavitz;Caleb C.J. ZavitzaDepartment of Pathology and Molecular Medicine, Centre for Gene Therapeutics andSearch for other works by this author on:Martin R. StämpfliMartin R. StämpfliaDepartment of Pathology and Molecular Medicine, Centre for Gene Therapeutics andbDepartment of Medicine, McMaster University, Hamilton, Ont., CanadaSearch for other works by this author on: