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Frontiers in Diabetes
The Insulinotropic Gut Hormone Glucagon-Like Peptide-1Available to Purchase
S.Karger AG
Volume
13
Status:
Available
ISBN electronic:
978-3-318-01934-6
ISBN print:
978-3-8055-6165-5
Book Series:
Frontiers in Diabetes
Publication date:
1997
Book Details
Glucagon-like peptide-1 (GLP-1) is a promising new therapeutic tool for the treatment of diabetes. Since the first reports describing its potent insulinotropic activity were published about a decade ago, knowledge of the incretin hormones, and GLP-1 in particular, has increased significantly. This timely volume summarizes what is now known about the molecular biology, physiology and pharmacology of GLP-1. Thorough coverage is given to the physiology of the hormone, including its generation, release and actions at pancreatic and extrapancreatic tissues. The intracellular mechanisms of GLP-1 are also described in detail. Discussion of the molecular biology includes the structure and functions of the genes coding for proglucagon and the GLP-1 receptor. A special feature of the book is the clinical information provided which includes data on the expression and release of GLP-1 and its potential use as a therapeutic agent for diabetes. Presenting the results of exciting new research, this book will be a valuable reference for endocrinologists, gastroenterologists, pharmacologists, physiologists and biochemists interested in this important hormone.
The Insulinotropic Gut Hormone Glucagon-Like Peptide-1
Edited by: H.C. Fehmann, B. Göke
https://doi.org/10.1159/isbn.978-3-318-01934-6
ISBN (print): 978-3-8055-6165-5
ISBN (electronic): 978-3-318-01934-6
Publisher: S.Karger AG
Published: 1997
Download citation file:
Digital Version
Pay-Per-View Access
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Print Version
The Insulinotropic Gut Hormone Glucagon-Like Peptide-1
$264.00
Table of Contents
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1 - 14: Design of the Entero-Insular AxisByWerner CreutzfeldWerner CreutzfeldDepartment of Medicine, Georg-August-University, Göttingen, GermanySearch for other works by this author on:
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15 - 23: Proglucagon Gene Structure and Regulation of ExpressionByJoel F. HabenerJoel F. HabenerLaboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, Mass., USASearch for other works by this author on:
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24 - 48: Posttranslational Processing of Proglucagon and Postsecretory Fate of Proglucagon ProductsByJens Juul Holst;Jens Juul HolstDepartment of Medical Physiology, Panum Institute, University of Copenhagen, DenmarkSearch for other works by this author on:Cathrine Ørskov;Cathrine ØrskovDepartment of Medical Physiology, Panum Institute, University of Copenhagen, DenmarkSearch for other works by this author on:Bolette Hartmann;Bolette HartmannDepartment of Medical Physiology, Panum Institute, University of Copenhagen, DenmarkSearch for other works by this author on:Carolyn F. DeaconCarolyn F. DeaconDepartment of Medical Physiology, Panum Institute, University of Copenhagen, DenmarkSearch for other works by this author on:
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49 - 64: Morphological Aspects of GLP-1 Expression in the IntestineByR. EisseleR. EisseleDepartment of Medicine, Philipps University Marburg, GermanySearch for other works by this author on:
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65 - 84: Release of GLP-1 into the CirculationByPatricia L. BrubakerPatricia L. BrubakerDepartment of Physiology, University of Toronto, Ont., CanadaSearch for other works by this author on:
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85 - 104: Glucagon-Like Peptide-1 Receptor in Relation to Its LigandByRüdiger Göke;Rüdiger GökeClinical Research Group for Gastrointestinal Endocrinology, Philipps University of Marburg, GermanySearch for other works by this author on:Alexandra Hareter;Alexandra HareterClinical Research Group for Gastrointestinal Endocrinology, Philipps University of Marburg, GermanySearch for other works by this author on:Torsten Vahl;Torsten VahlClinical Research Group for Gastrointestinal Endocrinology, Philipps University of Marburg, GermanySearch for other works by this author on:Hans-Peter Bode;Hans-Peter BodeClinical Research Group for Gastrointestinal Endocrinology, Philipps University of Marburg, GermanySearch for other works by this author on:Eike HoffmannEike HoffmannClinical Research Group for Gastrointestinal Endocrinology, Philipps University of Marburg, GermanySearch for other works by this author on:
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105 - 131: Effects of GLP-1 on Islet Hormone Secretion: Experimental StudiesByHans Christoph FehmannHans Christoph FehmannClinical Research Unit for Gastrointestinal Endocrinology, Department of Medicine, Philipps-University of Marburg, GermanySearch for other works by this author on:
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132 - 141: In vivo Regulation of Human Islet Hormone Secretion by Glucagon-Like Peptide-1ByDavid A. D'Alessio;David A. D'AlessioDivision of Endocrinology and Metabolism, Department of Medicine, University of Washington, Seattle, Wash., USASearch for other works by this author on:John W. EnsinckJohn W. EnsinckDivision of Endocrinology and Metabolism, Department of Medicine, University of Washington, Seattle, Wash., USASearch for other works by this author on:
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142 - 151: Signal Transduction of GLP-1ByHans-Peter BodeHans-Peter Bodea Department of Pharmacology and b Clinical Research Unit for Gastrointestinal Endocrinology, Department of Internal Medicine, Philipps University, Marburg, GermanySearch for other works by this author on:
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152 - 170: Islet Genes Regulated by GLP-1ByHans Christoph FehmannHans Christoph FehmannClinical Research Unit for Gastrointestinal Endocrinology, Department of Medicine, Philipps University of Marburg, GermanySearch for other works by this author on:
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171 - 193: Glucagon-Like Peptide-1 and the Glucose Competence Concept of Pancreatic Beta-Cell FunctionByGeorge G. Holz;George G. HolzaDiabetes Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, and bLaboratory of Molecular Endocrinology, Howard Hughes Medical Institute, Harvard Medical School, Massachusetts General Hospital, Boston, Mass., USASearch for other works by this author on:Colin A. LeechColin A. LeechaDiabetes Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, and bLaboratory of Molecular Endocrinology, Howard Hughes Medical Institute, Harvard Medical School, Massachusetts General Hospital, Boston, Mass., USASearch for other works by this author on:
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194 - 206: Effects of GLP-1 on Gastric Acid and Pancreatic Exocrine Secretion and on Gastrointestinal MotilityByMichael A. Nauck;Michael A. Naucka Department of Medicine, Ruhr-University, Knappschafts-Krankenhaus, Bochum, and b Department of Internal Medicine II, Technical University of Munich, Germany; c Department of Medical Physiology, Panum Institute, University of Copenhagen, DenmarkSearch for other works by this author on:Wolfgang Schepp;Wolfgang Scheppa Department of Medicine, Ruhr-University, Knappschafts-Krankenhaus, Bochum, and b Department of Internal Medicine II, Technical University of Munich, Germany; c Department of Medical Physiology, Panum Institute, University of Copenhagen, DenmarkSearch for other works by this author on:Jens J. Holst;Jens J. Holsta Department of Medicine, Ruhr-University, Knappschafts-Krankenhaus, Bochum, and b Department of Internal Medicine II, Technical University of Munich, Germany; c Department of Medical Physiology, Panum Institute, University of Copenhagen, DenmarkSearch for other works by this author on:Wolff H. SchmiegelWolff H. Schmiegela Department of Medicine, Ruhr-University, Knappschafts-Krankenhaus, Bochum, and b Department of Internal Medicine II, Technical University of Munich, Germany; c Department of Medical Physiology, Panum Institute, University of Copenhagen, DenmarkSearch for other works by this author on:
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207 - 211: Glucagon-Like Peptide-1 in the Central Nervous SystemByRüdiger GökeRüdiger GökeClinical Research Group for Gastrointestinal Endocrinology, Philipps University of Marburg, GermanySearch for other works by this author on:
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212 - 218: Extrapancreatic Action of GLP-1ByBurkhard GökeBurkhard GökeClinical Research Group for Gastrointestinal Endocrinology, Philipps University of Marburg, GermanySearch for other works by this author on:
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219 - 233: Lessons from Human Studies with Glucagon-Like Peptide-1: Potential of the Gut Hormone for Clinical UseByMaria M. ByrneMaria M. ByrneClinical Research Group for Gastrointestinal Endocrinology, Philipps University of Marburg, GermanySearch for other works by this author on:
