Fast Facts: Recognizing Refractory Myasthenia Gravis
An in-depth look at a rare disease
Myasthenia gravis (MG) is a rare autoimmune disorder of the neuromuscular junction, characterized by muscle fatigability. Patients often initially present with ocular symptoms, but in most cases the disease spreads beyond the eye muscles to more generalized involvement of bulbar, facial, neck, proximal limb and respiratory muscles. With adequate treatment, most patients with MG are able to live productive lives with few or no symptoms, but a distinct subset of patients do not respond to conventional treatment. With new treatment options on the horizon, it is important that these patients are identified.
'Fast Facts: Recognizing Refractory Myasthenia Gravis' takes an in-depth look at:
the immune-mediated nature of MG
classification of MG by disease type and severity, and antibody status
clinical presentation and diagnostic work-up
conventional management options
how patients with treatment-refractory MG present
the assessment tools that can be used to identify non-responders.
This informative resource will be of value to neurologists, neurology trainees and ophthalmologists caring for patients with this rare disease, as well as patients with MG who wish to have a deeper dialog with their doctor or patient group.
Definition and epidemiology
Pathophysiology and classification
Diagnosis and management: an overview
Assessment of disease severity and treatment response
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