Handbook of Clinical Gender Medicine
Gender medicine is an important new field in health and disease. It is derived from top-quality research and encompasses the biological and social determinants that underlie the susceptibility to disease and its consequences. In the future, consideration of the role of gender will undoubtedly become an integral feature of all research and clinical care.
Defining the role of gender in medicine requires a broad perspective on biology and diverse skills in biomedical and social sciences. When these scientific disciplines come together, a revolution in medical care is in the making. Covering twelve different areas of medicine, the practical and useful Handbook of Clinical Gender Medicine provides up-to-date information on the role of gender in the clinical presentation, diagnosis, and management of a wide range of common diseases.
The contributing authors of this handbook are all experts who, in well-referenced chapters, cogently and concisely explain how incorporation of gender issues into research can affect the medical understanding and treatment of heart disease, osteoporosis, arthritis, pain, violence, and malaria among other conditions. This intriguing and unique medical textbook provides readers with a valuable new perspective to understand biology and incorporate gender issues into the different branches of medicine.
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Table of Contents
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1 - 4: Gender MattersByJo Wainer;Jo WaineraEastern Health Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Vic.,bEastern Health, Box Hill, Vic., andSearch for other works by this author on:Zoe WainerZoe WainercDepartment of Surgery, St. Vincent’s Hospital, The University of Melbourne, Melbourne, Vic., AustraliaSearch for other works by this author on:
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5 - 7: Biological Sex and the Genome: What Makes Us Ourselves?ByMarianne J. LegatoMarianne J. LegatoPartnership for Gender-Specific Medicine, Columbia University, New York, N.Y., USASearch for other works by this author on:
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10 - 17: Gender Effects on Health and HealthcareByPaula R. DeColaPaula R. DeColaPfizer Inc., New York, N.Y., USASearch for other works by this author on:
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18 - 36: A Global War against Baby Girls: Sex-Selective Abortion Becomes a Worldwide PracticeByNicholas N. EberstadtNicholas N. EberstadtAmerican Enterprise Institute, Washington, D.C., USASearch for other works by this author on:
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37 - 51: Fetal ProgrammingByMarek GlezermanMarek GlezermanDepartments of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tiqwa, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelSearch for other works by this author on:
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52 - 67: Ambiguous GenitaliaByPierre D.E. Mouriquand;Pierre D.E. MouriquandaDepartment of Pediatric Urology, Hôpital Mère-Enfants – Groupement Hospitalier Est, Bron, France;Search for other works by this author on:Justine M. SchoberJustine M. SchoberbDepartment of Urology, UPMC Hamot, Erie, Pa., USASearch for other works by this author on:
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70 - 81: Chronic Stress and Allostatic LoadByRobert-Paul Juster;Robert-Paul JusterCenter for Studies on Human Stress, Fernand-Seguin Research Center, Louis-H. Lafontaine Hospital, Montreal, Que., CanadaSearch for other works by this author on:Sonia J. LupienSonia J. LupienCenter for Studies on Human Stress, Fernand-Seguin Research Center, Louis-H. Lafontaine Hospital, Montreal, Que., CanadaSearch for other works by this author on:
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82 - 91: AutismByRebecca Knickmeyer;Rebecca KnickmeyeraDepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C., USA;Search for other works by this author on:Simon Baron-CohenSimon Baron-CohenbAutism Research Center, Department of Psychiatry, University of Cambridge, Cambridge, UKSearch for other works by this author on:
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92 - 98: DepressionByDavid R. Rubinow;David R. RubinowDepartment of Psychiatry, Neurosciences Hospital, University of North Carolina at Chapel Hill, Chapel Hill, N.C., USASearch for other works by this author on:Claire D. CraftClaire D. CraftDepartment of Psychiatry, Neurosciences Hospital, University of North Carolina at Chapel Hill, Chapel Hill, N.C., USASearch for other works by this author on:
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99 - 124: Violence: Adaptive Regulated Aggression Contrasted with Violence Against WomenByTamara Kreinin;Tamara KreininaWomen and Population, United Nations Foundation, Washington, D.C., andSearch for other works by this author on:C. Garcia Moreno Esteva;C. Garcia Moreno EstevacWomen’s Health, World Health Organization, Geneva, Switzerland;Search for other works by this author on:Donald W. Pfaff;Donald W. PfaffbDepartment of Neurobiology and Behavior, The Rockefeller University, New York, N.Y., USA;Search for other works by this author on:Sellah Lusweti;Sellah LuswetidDepartment of Sociology, andSearch for other works by this author on:Halimu Suleiman ShauriHalimu Suleiman ShaurieDepartment of Humanities, Pwani University College, Kilifi, KenyaSearch for other works by this author on:
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126 - 132: Parkinson’s DiseaseByKarolina af Edholm;Karolina af EdholmCenter for Molecular Medicine, Department of Clinical Neuroscience, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:Per SvenningssonPer SvenningssonCenter for Molecular Medicine, Department of Clinical Neuroscience, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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133 - 142: StrokeByMia von EulerMia von EulerKarolinska Institutet Stroke Research Network at Södersjukhuset, Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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143 - 151: Multiple SclerosisByTomas OlssonTomas OlssonNeuroimmunology Unit, Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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152 - 156: EpilepsyByTorbjörn Tomson;Torbjörn TomsonDepartment of Clinical Neuroscience, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:Olafur SveinssonOlafur SveinssonDepartment of Clinical Neuroscience, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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157 - 162: Migraine and Other HeadachesByElisabet WaldenlindElisabet WaldenlindDepartment of Neurology, Karolinska University Hospital Huddinge, and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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164 - 168: FibromyalgiaByEva KosekEva KosekDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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169 - 172: Temporomandibular Joint DisordersByPei Feng Lim;Pei Feng LimCenter for Neurosensory Disorders and Department of Endodontics, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, N.C., USASearch for other works by this author on:William Maixner;William MaixnerCenter for Neurosensory Disorders and Department of Endodontics, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, N.C., USASearch for other works by this author on:Asma A. KhanAsma A. KhanCenter for Neurosensory Disorders and Department of Endodontics, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, N.C., USASearch for other works by this author on:
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173 - 182: Irritable Bowel SyndromeByLisa Ann Kilpatrick;Lisa Ann KilpatrickOppenheimer Family Center for Neurobiology of Stress and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Calif., USASearch for other works by this author on:Kirsten TillischKirsten TillischOppenheimer Family Center for Neurobiology of Stress and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Calif., USASearch for other works by this author on:
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183 - 188: Pain and AnalgesiaByDayna R. Loyd;Dayna R. LoydaPain Management Research Area, United States Army Institute of Surgical Research, Fort Sam Houston, Tex. andSearch for other works by this author on:Anne Z. MurphyAnne Z. MurphybNeuroscience Institute, Georgia State University, Atlanta, Ga., USASearch for other works by this author on:
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190 - 205: Coronary Heart DiseaseByKarin Schenck-GustafssonKarin Schenck-GustafssonCenter for Gender Medicine, Cardiac Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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206 - 211: Coronary Heart Disease and Female Sex HormonesByKarin Schenck-GustafssonKarin Schenck-GustafssonCenter for Gender Medicine, Cardiac Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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212 - 228: Heart FailureByBente Kühn MadsenBente Kühn MadsenHolbaek Sygehus, Holbaek, DenmarkSearch for other works by this author on:
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229 - 236: ArrhythmiasByPer Insulander;Per InsulanderDepartment of Cardiology, Karolinska University Hospital, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:Hans VallinHans VallinDepartment of Cardiology, Karolinska University Hospital, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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238 - 251: CancerByIngemar ErnbergIngemar ErnbergDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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252 - 265: Three Nuclear Receptors Involved in Gender-Related Proliferative Diseases (ER-β LXR-α, and LXR-β)ByMargaret Warner;Margaret WarneraCenter for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Tex., USA; andSearch for other works by this author on:Jan-Åke GustafssonJan-Åke GustafssonaCenter for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Tex., USA; andbDivision of Medical Nutrition, Department of Biosciences and Nutrition, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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268 - 272: Type 1 DiabetesByRonald C.W. Ma;Ronald C.W. MaDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, ChinaSearch for other works by this author on:Juliana C.N. ChanJuliana C.N. ChanDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, ChinaSearch for other works by this author on:
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273 - 282: Type 2 DiabetesByParinya Chamnan;Parinya ChamnanaMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UK;bDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, ChinaSearch for other works by this author on:Ronald C.W. Ma;Ronald C.W. MabDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, ChinaSearch for other works by this author on:Juliana C.N. ChanJuliana C.N. ChanbDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, ChinaSearch for other works by this author on:
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283 - 290: ObesityBySophia M. Rössner;Sophia M. RössneraDepartment of Women’s and Children’s Health, Karolinska University Hospital Solna andSearch for other works by this author on:Stephan RössnerStephan RössnerbObesity Unit, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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291 - 307: Pituitary and Thyroid DiseasesBySigbritt WernerSigbritt WernerDepartment of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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308 - 316: Diseases of Calcium Metabolism and Bone Metabolic DisordersByMarja ThorénMarja ThorénDepartment of Molecular Medicine and Surgery, and Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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317 - 326: Adrenal Disorders, Female Androgen Deficiency, Hirsutism, and Endocrine HypertensionByMarja ThorénMarja ThorénDepartment of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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327 - 334: TranssexualismByCecilia Dhejne;Cecilia DhejneCenter for Andrology and Sexual Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:Stefan ArverStefan ArverCenter for Andrology and Sexual Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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336 - 348: Systemic Lupus ErythematosusByMari Shiraishi;Mari ShiraishiDivision of Rheumatology and Immunology, Department of Medicine, Duke University Medical Center, Durham, N.C., USASearch for other works by this author on:Megan ClowseMegan ClowseDivision of Rheumatology and Immunology, Department of Medicine, Duke University Medical Center, Durham, N.C., USASearch for other works by this author on:
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349 - 357: Rheumatoid ArthritisByNienke Lesuis;Nienke LesuisaMedical Faculty, Radboud University, Nijmegen, The Netherlands;Search for other works by this author on:Ronald F. van VollenhovenRonald F. van VollenhovenbUnit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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358 - 366: OsteoarthritisByMaryFran Sowers;MaryFran SowersDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Mich., USASearch for other works by this author on:Carrie A. Karvonen-GutierrezCarrie A. Karvonen-GutierrezDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Mich., USASearch for other works by this author on:
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367 - 379: SpondyloarthritisByLihi Eder;Lihi EderCenter for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto Western Research Institute, University of Toronto, Toronto, Ont., CanadaSearch for other works by this author on:Dafna D. GladmanDafna D. GladmanCenter for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto Western Research Institute, University of Toronto, Toronto, Ont., CanadaSearch for other works by this author on:
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380 - 385: GoutByMichael S. HershfieldMichael S. HershfieldDivision of Rheumatology and Immunology, Department of Medicine, Duke University Medical Center, Durham, N.C., USASearch for other works by this author on:
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388 - 395: HIV InfectionByValerio TozziValerio TozziNational Institute for Infectious Diseases ‘Lazzaro Spallanzani’, Rome, ItalySearch for other works by this author on:
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396 - 404: MalariaByAnna Färnert;Anna FärnertaInfectious Diseases Unit, Department of Medicine, Karolinska Institutet,bDepartment of Infectious Diseases, Karolinska University Hospital Solna, andSearch for other works by this author on:Asli KulaneAsli KulanecDivision of Global Health (IHCAR), Department of Public Health Sciences, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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405 - 413: Measles InfectionByPeter AabyPeter AabyBandim Health Project, National Institute of Health, Bissau Codex, Guinea-BissauSearch for other works by this author on:
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414 - 425: TuberculosisByAnna Ekéus ThorsonAnna Ekéus ThorsonDivision of Global Health (IHCAR), Department of Public Health Sciences, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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428 - 437: Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia, and Overactive BladderByRalph PeekerRalph PeekerDepartment of Urology, Sahlgrenska University Hospital, Gothenburg, SwedenSearch for other works by this author on:
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438 - 445: Sexual Dysfunction in WomenByKatarina ÖbergKatarina ÖbergCenter for Andrology and Sexual Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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446 - 456: Sexual Dysfunction in MenByJacques BuvatJacques BuvatCentre d’Etude et de Traitement de la Pathologie de I’Appareil Reproducteur et de la Psychosomatique (CETPARP), Lille, FranceSearch for other works by this author on:
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457 - 463: Chronic Kidney DiseaseByJuan-Jesús CarreroJuan-Jesús CarreroaDivision of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, andbCenter for Gender Medicine, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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466 - 472: Women in Clinical Drug Trials: United States Food and Drug Administration Update on Policies and PracticesByAmeeta ParekhAmeeta ParekhCenter for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Md., USASearch for other works by this author on:
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473 - 479: Drug Disposition and EffectByAmy C.M. Mattison Faye;Amy C.M. Mattison FayeaArnold School of Public Health, University of South Carolina, Columbia, S.C.,Search for other works by this author on:Donald R. MattisonDonald R. MattisonbDivision of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md., USA, andcRisk Sciences International, Ottawa, Ont., CanadaSearch for other works by this author on:
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482 - 488: Aging in a Gendered Society: Social and Biological Determinants of Health in the Elderly PopulationByMarti G. ParkerMarti G. ParkerAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, SwedenSearch for other works by this author on:
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489 - 494: MultimorbidityByFrancesca Mangialasche;Francesca MangialascheAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, SwedenSearch for other works by this author on:Alessandra Marengoni;Alessandra MarengoniAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, SwedenSearch for other works by this author on:Miia KivipeltoMiia KivipeltoAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, SwedenSearch for other works by this author on:
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495 - 503: DementiaByHui-Xin Wang;Hui-Xin WangAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, SwedenSearch for other works by this author on:Miia KivipeltoMiia KivipeltoAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, SwedenSearch for other works by this author on:
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504 - 507: CognitionByAgneta Herlitz;Agneta HerlitzAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, SwedenSearch for other works by this author on:Johanna LovénJohanna LovénAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, SwedenSearch for other works by this author on: