Endothelin in Renal Physiology and Disease
Endothelin is a 21-amino acid peptide that exerts uniquely potent and long-lasting effects on the kidney, including regulation of water and electrolyte excretion, blood pressure, cell growth, inflammation and fibrosis. During the past 10 years, the field has evolved rapidly; we are now uncovering the potential importance of endothelin receptor antagonists (ERAs) in the treatment of kidney disease. This book reviews experimental concepts, preclinical studies and clinical data which form the basis of our current understanding of the association between endothelin and kidney disease. Acclaimed experts in pharmacology, molecular biology, physiology, cardiovascular medicine, and nephrology have contributed timely reviews dealing with renal pharmacology and physiology of endothelin, the role of endothelin in renal disease development and ERAs in preclinical studies, and the current state of clinical development of ERA therapy in renal medicine. The publication at hand will be a valuable reference source for nephrologists, internists and other healthcare professionals, renal physiologists and molecular biologists, post-doctoral researchers and students in the life sciences, as well as for scientists and decision makers in drug research and development.
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Table of Contents
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1 - 17: Pharmacology of Renal Endothelin ReceptorsByAnthony P. Davenport;Anthony P. DavenportClinical Pharmacology Unit, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UKSearch for other works by this author on:Janet J. MaguireJanet J. MaguireClinical Pharmacology Unit, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UKSearch for other works by this author on:
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18 - 34: Renal Function and Blood Pressure: Molecular Insights into the Biology of Endothelin-1ByNicolas Vignon-Zellweger;Nicolas Vignon-ZellwegeraDepartment of Clinical Pharmacy, Kobe Pharmaceutical University, andSearch for other works by this author on:Susi Heiden;Susi HeidenaDepartment of Clinical Pharmacy, Kobe Pharmaceutical University, andSearch for other works by this author on:Noriaki EmotoNoriaki EmotoaDepartment of Clinical Pharmacy, Kobe Pharmaceutical University, andbDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, JapanSearch for other works by this author on:
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35 - 49: Endothelin and the Renal VasculatureByZhengrong Guan;Zhengrong GuanDepartment of Physiology, Georgia Health Sciences University, Augusta, Ga., USASearch for other works by this author on:Edward W. InschoEdward W. InschoDepartment of Physiology, Georgia Health Sciences University, Augusta, Ga., USASearch for other works by this author on:
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50 - 62: Endothelin Signaling and Actions in the Renal MesangiumByAndrey SorokinAndrey SorokinKidney Disease Center, Division of Nephrology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisc., USASearch for other works by this author on:
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63 - 75: Regulation of Sodium Transport in the Proximal Tubule by EndothelinByYe Zhang;Ye ZhangaDepartment of Cardiology, Daping Hospital, The Third Military Medical University, andbChongqing Institute of Cardiology, Chongqing, P.R. China;Search for other works by this author on:Pedro A. Jose;Pedro A. JosecCenter for Molecular Physiology Research, Children’s National Medical Center and Department of Pediatrics, George Washington University School of Medicine and Public Health, Washington, D.C., USASearch for other works by this author on:Chunyu ZengChunyu ZengaDepartment of Cardiology, Daping Hospital, The Third Military Medical University, andbChongqing Institute of Cardiology, Chongqing, P.R. China;Search for other works by this author on:
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76 - 83: Role of Endothelin in Thick Ascending Limb Sodium Chloride TransportByVanesa D. Ramseyer;Vanesa D. RamseyeraHypertension and Vascular Research Division, Henry Ford Hospital andbDepartment of Physiology, Wayne State University, Detroit, Mich., USASearch for other works by this author on:Pablo D. Cabral;Pablo D. CabralaHypertension and Vascular Research Division, Henry Ford Hospital andSearch for other works by this author on:Jeffrey L. GarvinJeffrey L. GarvinaHypertension and Vascular Research Division, Henry Ford Hospital andbDepartment of Physiology, Wayne State University, Detroit, Mich., USASearch for other works by this author on:
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84 - 93: Endothelins and Kidney AcidificationByDonald E. WessonDonald E. WessonTexas A&M Health Sciences Center College of Medicine, Scott and White Healthcare, Temple, Tex., USASearch for other works by this author on:
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94 - 106: Endothelin and Collecting Duct Sodium and Water TransportByDonald E. KohanDonald E. KohanDivision of Nephrology, University of Utah Health Sciences Center, Salt Lake City, Utah, USASearch for other works by this author on:
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107 - 119: Endothelin in the Control of Renal Sympathetic Nerve ActivityByUlla C. KoppUlla C. KoppDepartments of Internal Medicine and Pharmacology, University of Iowa Carver, College of Medicine and Department of Veterans Affairs Medical Center, Iowa City, Iowa, USASearch for other works by this author on:
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120 - 138: Endothelin and Podocyte Injury in Chronic Kidney DiseaseByCécile Fligny;Cécile FlignyaINSERM and Université Paris-Descartes, Paris Cardiovascular Research Centre – PARCC, Paris, France;Search for other works by this author on:Matthias Barton;Matthias BartonbMolecular Internal Medicine, University of Zürich, Zürich, SwitzerlandSearch for other works by this author on:Pierre-Louis TharauxPierre-Louis TharauxaINSERM and Université Paris-Descartes, Paris Cardiovascular Research Centre – PARCC, Paris, France;Search for other works by this author on:
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139 - 148: Endothelin in Diabetic Renal DiseaseByKerstin Benz;Kerstin BenzDepartments for Pediatrics and Nephropathology, University of Erlangen-Nürnberg, Erlangen, GermanySearch for other works by this author on:Kerstin AmannKerstin AmannDepartments for Pediatrics and Nephropathology, University of Erlangen-Nürnberg, Erlangen, GermanySearch for other works by this author on:
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149 - 159: Endothelin, Nitric Oxide, and Reactive Oxygen Species in Diabetic Kidney DiseaseByJennifer S. Pollock;Jennifer S. PollockMedical College of Georgia, Georgia Health Sciences University, Augusta, Ga., USASearch for other works by this author on:David M. PollockDavid M. PollockMedical College of Georgia, Georgia Health Sciences University, Augusta, Ga., USASearch for other works by this author on:
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160 - 170: Endothelin in Renal Inflammation and HypertensionByMohamed A. Saleh;Mohamed A. SalehVascular Biology Center, Department of Surgery, Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Ga., USASearch for other works by this author on:David M. PollockDavid M. PollockVascular Biology Center, Department of Surgery, Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Ga., USASearch for other works by this author on:
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171 - 184: Endothelin in Chronic Proteinuric Kidney DiseaseByElena Gagliardini;Elena GagliardiniMario Negri Institute for Pharmacological Research, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, ItalySearch for other works by this author on:Simona Buelli;Simona BuelliMario Negri Institute for Pharmacological Research, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, ItalySearch for other works by this author on:Ariela BenigniAriela BenigniMario Negri Institute for Pharmacological Research, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, ItalySearch for other works by this author on:
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185 - 199: Endothelin in Renal Injury due to Sickle Cell DiseaseByPierre-Louis TharauxPierre-Louis TharauxInserm, Université Paris Descartes, Paris, FranceSearch for other works by this author on:
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200 - 209: Endothelin in Polycystic Kidney DiseaseByMing-Yang Chang;Ming-Yang ChangaKidney Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan;Search for other works by this author on:Albert C.M. OngAlbert C.M. OngbKidney Genetics Group, Academic Nephrology Unit, University of Sheffield Medical School, Sheffield, UKSearch for other works by this author on:
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210 - 222: Endothelin Antagonism and Reversal of Proteinuric Renal Disease in HumansByMatthias BartonMatthias BartonMolecular Internal Medicine, University of Zürich, Zürich, SwitzerlandSearch for other works by this author on:
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223 - 234: Endothelin Antagonism in Patients with Resistant Hypertension and Hypertension NephropathyByIvana Lazich;Ivana LazichHypertensive Diseases Unit, University of Chicago, Pritzker School of Medicine, Chicago, Ill., USASearch for other works by this author on:George L. BakrisGeorge L. BakrisHypertensive Diseases Unit, University of Chicago, Pritzker School of Medicine, Chicago, Ill., USASearch for other works by this author on:
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235 - 242: Endothelin Receptor Blockade in Patients with Diabetic NephropathyByTon J. Rabelink;Ton J. RabelinkaLUMC Department of Nephrology, Leiden, The Netherlands;Search for other works by this author on:Donald E. KohanDonald E. KohanbDivision of Nephrology, University of Utah, Health Sciences Center, Salt Lake City, Utah, USASearch for other works by this author on:
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243 - 254: Endothelin Antagonism in Patients with Nondiabetic Chronic Kidney DiseaseByNeeraj Dhaun;Neeraj DhaunaClinical Pharmacology Unit, British Heart Foundation (BHF) Centre of Research Excellence (CoRE), University of Edinburgh, Queen’s Medical Research Institute,bDepartment of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UKSearch for other works by this author on:Jane Goddard;Jane GoddardaClinical Pharmacology Unit, British Heart Foundation (BHF) Centre of Research Excellence (CoRE), University of Edinburgh, Queen’s Medical Research Institute,bDepartment of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UKSearch for other works by this author on:David J. WebbDavid J. WebbaClinical Pharmacology Unit, British Heart Foundation (BHF) Centre of Research Excellence (CoRE), University of Edinburgh, Queen’s Medical Research Institute,Search for other works by this author on:
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255 - 260: Endothelin Antagonists in Clinical Trials: Lessons LearnedByMatthias Barton;Matthias BartonaMolecular Internal Medicine, University of Zürich, Zürich, Switzerland;Search for other works by this author on:Donald E. KohanDonald E. KohanbDivision of Nephrology, University of Utah, Health Sciences Center, Salt Lake City, Utah, USASearch for other works by this author on: