Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract: Mechanisms, Prevention and Treatment
In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for prevention and treatment of gastrointestinal injury. Nevertheless, many people worldwide still suffer from gastrointestinal damage. This book contains contributions by an international panel of researchers in the form of up-to-date reviews on the mechanisms of gastrointestinal injury and protection. These are complemented by papers discussing how these new findings about cell/tissue injury and cytoprotection/organoprotection can be applied to the prevention and treatment of tissue damage in the gastrointestinal tract. Moreover, the publication includes a special chapter on Andre Robert, who has discovered the phenomenon of gastric cytoprotection. This publication will be of great interest for both basic and clinical researchers in gastroenterology and pharmacology, reviewing the advances made so far and pointing towards future developments.
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Table of Contents
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1 - 23: The ‘Gastric Cytoprotection’ Concept of Andre Robert and the Origins of a New Series of International SymposiaBySandor Szabo;Sandor SzaboaVA Medical Centers, Long Beach, Calif. and Departments of Pathology and Pharmacology, University of California, Irvine, Calif.Search for other works by this author on:Yvette Tache;Yvette TachecVA Medical Centers, Los Angeles, Calif. and Department of Medicine, Digestive Disease Division, University of California, Los Angeles, Calif., USASearch for other works by this author on:Andrzej TarnawskiAndrzej TarnawskibVA Medical Centers, Long Beach, Calif. and Department of Medicine, University of California, Irvine, Calif.Search for other works by this author on:
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24 - 31: Importance of Translational Research in GI Pharmacology: Lessons Learned from the Successes in HistoryByDuan Chen;Duan ChenDepartments of Cancer Research and Molecular Medicine and Surgery, Norwegian University of Science and Technology and St. Olav’s University Hospital, Trondheim, NorwaySearch for other works by this author on:Chun-Mei ZhaoChun-Mei ZhaoDepartments of Cancer Research and Molecular Medicine and Surgery, Norwegian University of Science and Technology and St. Olav’s University Hospital, Trondheim, NorwaySearch for other works by this author on:
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32 - 40: Acetic Acid Ulcer Model – State of the Art in 2012ByS. Okabe;S. OkabeDepartment of Pharmacology and Experimental Therapeutics and Pharmaceutical University, Misasagi, Yamashina, Kyoto, JapanSearch for other works by this author on:K. Amagase;K. AmagaseDepartment of Pharmacology and Experimental Therapeutics and Pharmaceutical University, Misasagi, Yamashina, Kyoto, JapanSearch for other works by this author on:K. TakeuchiK. TakeuchiDepartment of Pharmacology and Experimental Therapeutics and Pharmaceutical University, Misasagi, Yamashina, Kyoto, JapanSearch for other works by this author on:
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41 - 51: Roles of EP4 Receptors in Protective and Healing-Promoting Effects of Prostaglandin E2 on NSAID-Induced Small Intestinal DamageByKoji TakeuchiKoji TakeuchiDepartment of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, JapanSearch for other works by this author on:
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52 - 60: Role of Food and Enterobacteria in the Formation and Prevention of Small Intestinal Damage Induced by NSAIDsByHiroshi Satoh;Hiroshi SatohDepartment of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, JapanSearch for other works by this author on:Koji TakeuchiKoji TakeuchiDepartment of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, JapanSearch for other works by this author on:
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61 - 70: Synergic Effect of NSAID and Gastric Acid on Superoxide-Anion Production in StomachByHirofumi Matsui;Hirofumi MatsuiDivision of Gastroenterology, University of Tsukuba, Tsukuba, JapanSearch for other works by this author on:Tsuyoshi KanekoTsuyoshi KanekoDivision of Gastroenterology, University of Tsukuba, Tsukuba, JapanSearch for other works by this author on:
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71 - 78: Development of NSAIDs with Lower Gastric Side EffectByTohru MizushimaTohru MizushimaFaculty of Pharmacy, Keio University, Tokyo, JapanSearch for other works by this author on:
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79 - 86: NSAID-Mucosal Injury: Roles of Drug Chemistry in PathogenesisByK.D. RainsfordK.D. RainsfordBiomedical Research Centre, Sheffield Hallam University, Sheffield, UKSearch for other works by this author on:
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87 - 96: Animal Model for Evaluating Gastric Bleeding and Ulcerogenic Response Induced by Aspirin plus ClopidogrelByChitose Izuhara;Chitose IzuharaDepartment of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, JapanSearch for other works by this author on:Shinichi Takayama;Shinichi TakayamaDepartment of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, JapanSearch for other works by this author on:Misaki Itayama;Misaki ItayamaDepartment of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, JapanSearch for other works by this author on:Naoto Hoshin;Naoto HoshinDepartment of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, JapanSearch for other works by this author on:Yuji Yoshida;Yuji YoshidaDepartment of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, JapanSearch for other works by this author on:Koji TakeuchiKoji TakeuchiDepartment of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, JapanSearch for other works by this author on:
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97 - 105: Effects of Ibuprofen, and Some Analogues, on the Muscle Tone of Isolated Segments of the Common Digital Artery of the Fallow Deer (Dama dama)ByB.A. Callingham;B.A. CallinghamaDepartment of Pharmacology, University of Cambridge, Cambridge, andSearch for other works by this author on:A. Maini;A. MainiaDepartment of Pharmacology, University of Cambridge, Cambridge, andSearch for other works by this author on:F. Masood;F. MasoodaDepartment of Pharmacology, University of Cambridge, Cambridge, andSearch for other works by this author on:M. Munnawwar;M. MunnawwaraDepartment of Pharmacology, University of Cambridge, Cambridge, andSearch for other works by this author on:C. Rhodes;C. RhodesaDepartment of Pharmacology, University of Cambridge, Cambridge, andSearch for other works by this author on:A.S. Milton;A.S. MiltonaDepartment of Pharmacology, University of Cambridge, Cambridge, andSearch for other works by this author on:K.D. RainsfordK.D. RainsfordbBiomedical Research Centre, Sheffield Hallam University, Sheffield, UKSearch for other works by this author on:
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106 - 114: Psychological Stress Induces Visceral Analgesic or Hyperalgesic Response in Rodents: A Role of PreconditionsByAgata Mulak;Agata MulakaDepartments of Medicine and Genome Sciences, University of Washington, Seattle Wash., USA andbMolecular Genetics Laboratory University Eye Hospital, Tübingen, GermanySearch for other works by this author on:Muriel Larauche;Muriel LaraucheaDepartments of Medicine and Genome Sciences, University of Washington, Seattle Wash., USA andSearch for other works by this author on:Yvette TachéYvette TachéaDepartments of Medicine and Genome Sciences, University of Washington, Seattle Wash., USA andSearch for other works by this author on:
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115 - 123: Neurobiology of Corticotropin-Releasing Factor in the Enteric Nervous System during StressBySumei Liu;Sumei LiuaDepartment of Biology, College of Science and Health, University of Wisconsin – La Crosse, La Crosse, Wisc., andSearch for other works by this author on:Jackie D. WoodJackie D. WoodbDepartment of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio, USASearch for other works by this author on:
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124 - 133: Corticotropin-Releasing Factor May Protect the Gastric Mucosa in Stress through Involvement of GlucocorticoidsByL.P. Filaretova;L.P. FilaretovaLaboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, RussiaSearch for other works by this author on:T.R. Bagaeva;T.R. BagaevaLaboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, RussiaSearch for other works by this author on:O. Yu Morozova;O. Yu MorozovaLaboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, RussiaSearch for other works by this author on:M.A. MayzinaM.A. MayzinaLaboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, RussiaSearch for other works by this author on:
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134 - 141: Pathogenic Potential of Psychogenic Stress in Gastric Mucosal InjuryByV.I. Ovsiannikov;V.I. OvsiannikovDepartment of Visceral Systems Physiology, Institute of Experimental Medicine Russian Academy of Medical Sciences, St. Petersburg, RussiaSearch for other works by this author on:T.P. BerezinaT.P. BerezinaDepartment of Visceral Systems Physiology, Institute of Experimental Medicine Russian Academy of Medical Sciences, St. Petersburg, RussiaSearch for other works by this author on:
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142 - 147: Advances in Understanding Inflammation in Esophageal DiseaseByRichard H. Hunt;Richard H. HuntRm HSC: 4W8, Farncombe Family Digestive Disease Research Institute, Division of Gastroenterology, Department of Medicine, McMaster University Health Science Centre, Hamilton, Ont., CanadaSearch for other works by this author on:Yuhong YuanYuhong YuanRm HSC: 4W8, Farncombe Family Digestive Disease Research Institute, Division of Gastroenterology, Department of Medicine, McMaster University Health Science Centre, Hamilton, Ont., CanadaSearch for other works by this author on:
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148 - 160: Physiopathology of Esophageal Inflammation, Ulcerogenesis and Repair by Studying the Profile of GlycoconjugateByOksana ZayachkivskaOksana ZayachkivskaPhysiology Department, Lviv National Medical University, Lviv, UkraineSearch for other works by this author on:
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161 - 169: Analysis of the Effect of Different Neuropeptides in Gastric Mucosal Defense Initiated CentrallyByKlara GyiresKlara GyiresDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, HungarySearch for other works by this author on:
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170 - 180: Sulforaphane Enhances Protection and Repair of Gastric Mucosa against Oxidative Stress via Nrf2-Dependent MechanismsByAkinori YanakaAkinori YanakaDivision of Gastroenterology, Hitachi Medical Education and Research Center, Faculty of Medicine, University of Tsukuba, Hitachi, JapanSearch for other works by this author on:
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181 - 190: Involvement of Renin-Angiotensin System and Vasoactive Angiotensin-(1–7) Metabolite of Angiotensin II in Gastric Mucosal Injury and GastroprotectionByTomasz Brzozowski;Tomasz BrzozowskiDepartment of Physiology, Jagiellonian University Medical College, Cracow, PolandSearch for other works by this author on:Slawomir Kwiecien;Slawomir KwiecienDepartment of Physiology, Jagiellonian University Medical College, Cracow, PolandSearch for other works by this author on:Aleksandra Szlachcic;Aleksandra SzlachcicDepartment of Physiology, Jagiellonian University Medical College, Cracow, PolandSearch for other works by this author on:Malgorzata Strzalka;Malgorzata StrzalkaDepartment of Physiology, Jagiellonian University Medical College, Cracow, PolandSearch for other works by this author on:Danuta Drozdowicz;Danuta DrozdowiczDepartment of Physiology, Jagiellonian University Medical College, Cracow, PolandSearch for other works by this author on:Robert Pajdo;Robert PajdoDepartment of Physiology, Jagiellonian University Medical College, Cracow, PolandSearch for other works by this author on:Jakub Szmyd;Jakub SzmydDepartment of Physiology, Jagiellonian University Medical College, Cracow, PolandSearch for other works by this author on:Stanislaw J. Konturek;Stanislaw J. KonturekDepartment of Physiology, Jagiellonian University Medical College, Cracow, PolandSearch for other works by this author on:Wieslaw W. PawlikWieslaw W. PawlikDepartment of Physiology, Jagiellonian University Medical College, Cracow, PolandSearch for other works by this author on:
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191 - 201: Effect of Pentadecapeptide BPC 157 on Gastrointestinal TractByP.S. Sikiric;P.S. SikiricDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:S. Seiwerth;S. SeiwerthDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:R. Rucman;R. RucmanDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:B. Turkovic;B. TurkovicDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:D.S. Rokotov;D.S. RokotovDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:L. Brcic;L. BrcicDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:M. Sever;M. SeverDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:R. Klicek;R. KlicekDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:B. Radic;B. RadicDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:D. Drmic;D. DrmicDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:S. Ilic;S. IlicDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:D. Kolenc;D. KolencDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:J. Suran;J. SuranDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:H. Vrcic;H. VrcicDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:B. SebecicB. SebecicDepartment of Pharmacology Medical Faculty University of Zagreb, Zagreb, CroatiaSearch for other works by this author on:
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202 - 211: Pathobiology of Gastric Carcinoids and Adenocarcinomas in Rodent Models and Patients: Studies of Gastrocystoplasty, Gender-Related Factors and AutophagyByReidar Alexander Vigen;Reidar Alexander VigenDepartments of Cancer Research and Molecular Medicine and Surgery, Norwegian University of Science and Technology and St. Olav’s University Hospital, Trondheim, NorwaySearch for other works by this author on:Duan Chen;Duan ChenDepartments of Cancer Research and Molecular Medicine and Surgery, Norwegian University of Science and Technology and St. Olav’s University Hospital, Trondheim, NorwaySearch for other works by this author on:Chun-Mei ZhaoChun-Mei ZhaoDepartments of Cancer Research and Molecular Medicine and Surgery, Norwegian University of Science and Technology and St. Olav’s University Hospital, Trondheim, NorwaySearch for other works by this author on:
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212 - 218: Roles of the Hydrogen Sulfide/T-Type Calcium Channel System in Somatic and Visceral Pain ProcessingByAtsufumi Kawabata;Atsufumi KawabataDivision of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Higashi-Osaka, JapanSearch for other works by this author on:Maho MatsunamiMaho MatsunamiDivision of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Higashi-Osaka, JapanSearch for other works by this author on:
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219 - 229: Age-Dependent Role of Vasopressin in Susceptibility of Gastric Mucosa to Indomethacin-Induced InjuryByD. Zelena;D. ZelenaaHungarian Academy of Sciences, Institute of Experimental Medicine, Behavioral and Stress Studies, Budapest, Hungary;Search for other works by this author on:O. Yu Morozova;O. Yu MorozovabRussian Academy of Sciences, Pavlov Institute of Physiology, Laboratory of Experimental Endocrinology, St. Petersburg, RussiaSearch for other works by this author on:L.P. FilaretovaL.P. FilaretovabRussian Academy of Sciences, Pavlov Institute of Physiology, Laboratory of Experimental Endocrinology, St. Petersburg, RussiaSearch for other works by this author on:
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230 - 241: From Mucosal Energy Metabolism to Capsaicin – Strategies for Understanding Mucosal ProtectionByImre L. Szabó;Imre L. SzabóFirst Department of Medicine, Medical and Health Centre, University of Pécs, Pécs, HungarySearch for other works by this author on:Jozsef Czimmer;Jozsef CzimmerFirst Department of Medicine, Medical and Health Centre, University of Pécs, Pécs, HungarySearch for other works by this author on:Gyula MózsikGyula MózsikFirst Department of Medicine, Medical and Health Centre, University of Pécs, Pécs, HungarySearch for other works by this author on: